Vikas Gupta, MD/PhD
Assistant Professor of Medicine (Digestive Diseases) and of Pathology; Associate Director, Gastroenterology Fellowship Program, Internal Medicine
Research & Publications
Biography
News
Locations
Research Summary
Dr. Gupta's lab utilizes a combination of murine genetics, histology, bulk/single cell sequencing technologies, patient samples, and other approaches to understand fibrosing, inflammatory, and cancerous diseases of the biliary tree. His goal is to dissect biliary epithelial-mesenchymal crosstalk in homeostasis and disease to gain insights into therapeutic targets for patients suffering from cholangiopathies.
Research Interests
Cholestasis, Extrahepatic; Cholestasis, Intrahepatic; Cell Biology; Fibrosis; Hypertension, Portal; Liver Cirrhosis; Molecular Biology; Cholangitis, Sclerosing; Genomics
Selected Publications
- Cell and Tissue Therapy for the Treatment of Chronic Liver DiseaseBram Y, Nguyen DT, Gupta V, Park J, Richardson C, Chandar V, Schwartz RE. Cell and Tissue Therapy for the Treatment of Chronic Liver Disease Annual Review Of Biomedical Engineering 2021, 23: 1-30. PMID: 33974812, PMCID: PMC8864721, DOI: 10.1146/annurev-bioeng-112619-044026.
- A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and OrganoidsYang L, Han Y, Nilsson-Payant BE, Gupta V, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffré F, Zhang T, Kim TW, Harschnitz O, Redmond D, Houghton S, Liu C, Naji A, Ciceri G, Guttikonda S, Bram Y, Nguyen DT, Cioffi M, Chandar V, Hoagland DA, Huang Y, Xiang J, Wang H, Lyden D, Borczuk A, Chen HJ, Studer L, Pan FC, Ho DD, tenOever BR, Evans T, Schwartz RE, Chen S. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell 2020, 27: 125-136.e7. PMID: 32579880, PMCID: PMC7303620, DOI: 10.1016/j.stem.2020.06.015.
- Hedgehog Signaling Demarcates a Niche of Fibrogenic Peribiliary Mesenchymal CellsGupta V, Gupta I, Park J, Bram Y, Schwartz RE. Hedgehog Signaling Demarcates a Niche of Fibrogenic Peribiliary Mesenchymal Cells Gastroenterology 2020, 159: 624-638.e9. PMID: 32289375, PMCID: PMC8204800, DOI: 10.1053/j.gastro.2020.03.075.
- Adjuvant use of antibiotics with corticosteroids in inflammatory bowel disease exacerbations requiring hospitalisation: a retrospective cohort study and meta‐analysisGupta V, Rodrigues R, Nguyen D, Sauk J, Khalili H, Yajnik V, Ananthakrishnan AN. Adjuvant use of antibiotics with corticosteroids in inflammatory bowel disease exacerbations requiring hospitalisation: a retrospective cohort study and meta‐analysis Alimentary Pharmacology & Therapeutics 2015, 43: 52-60. PMID: 26541937, PMCID: PMC4673010, DOI: 10.1111/apt.13454.
- Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regenerationFang Y, Gupta V, Karra R, Holdway JE, Kikuchi K, Poss KD. Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 13416-13421. PMID: 23901114, PMCID: PMC3746860, DOI: 10.1073/pnas.1309810110.
- An Injury-Responsive Gata4 Program Shapes the Zebrafish Cardiac VentricleGupta V, Gemberling M, Karra R, Rosenfeld GE, Evans T, Poss KD. An Injury-Responsive Gata4 Program Shapes the Zebrafish Cardiac Ventricle Current Biology 2013, 23: 1221-1227. PMID: 23791730, PMCID: PMC3759223, DOI: 10.1016/j.cub.2013.05.028.
- Clonally dominant cardiomyocytes direct heart morphogenesisGupta V, Poss KD. Clonally dominant cardiomyocytes direct heart morphogenesis Nature 2012, 484: 479-484. PMID: 22538609, PMCID: PMC3340018, DOI: 10.1038/nature11045.
- tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regenerationKikuchi K, Gupta V, Wang J, Holdway JE, Wills AA, Fang Y, Poss KD. tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration Development 2011, 138: 2895-2902. PMID: 21653610, PMCID: PMC3119303, DOI: 10.1242/dev.067041.