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Valerie Horsley, PhD

Professor of Molecular, Cellular and Developmental Biology and Associate Professor of Dermatology

Research & Publications
Biography
News

Research Summary

Our laboratory studies the cellular and molecular mechanisms that control stem cell activity and function within epithelia, the tissues that line our internal organs and outer surfaces. We use the mouse as a genetic model system to study how adult stem cells within epithelial tissues maintain tissue homeostasis, wound healing and can contribute to cancer formation. The primary epithelial tissue we use is the mammalian skin, which contains multiple stem cell populations and forms a complex tissue that protects our bodies from external pathogens and loss of internal bodily fluids. Mammalian skin is an excellent model to study developmental and stem cell biology because the epidermis and its appendages are in a constant state of regeneration, which is actively sustained by tissue stem cells.

Our vision is to understand the cellular and molecular regulation of epithelial tissue development and regeneration. We focus on both the intrinsic transcriptional as well as the extrinsic signaling mechanisms that control these processes.

Coauthors

Research Interests

Dermatology; Epithelial Cells; Molecular Biology; Regeneration; Skin Diseases; Stem Cells; Tissue Survival

Research Image

Skin highlighting dermal adipocytes

Adiponectin-Cre; mT/mG mice show adipocytes with mG+ membranes surrounding mature hair follicles in the skin

Selected Publications

Langerhans cells are essential components of the angiogenic niche during murine skin repairWasko R, Bridges K, Pannone R, Sidhu I, Xing Y, Naik S, Miller-Jensen K, Horsley V. Langerhans cells are essential components of the angiogenic niche during murine skin repair. Developmental Cell 2022, 57: 2699-2713.e5. PMID: 36493773, PMCID: PMC10848275, DOI: 10.1016/j.devcel.2022.11.012.
Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteinsTsai P, Cameron C, Forni M, Wasko R, Naughton B, Horsley V, Gerstein M, Schlieker C. Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins. Cell Reports 2022, 41: 111675. PMID: 36417855, PMCID: PMC9827541, DOI: 10.1016/j.celrep.2022.111675.
Adipocyte plasticity in tissue regeneration, repair, and diseaseHorsley V. Adipocyte plasticity in tissue regeneration, repair, and disease. Current Opinion In Genetics & Development 2022, 76: 101968. PMID: 35988318, DOI: 10.1016/j.gde.2022.101968.
124 Wnt signaling activation causes ATGL-dependent lipolysis in skin fibrosisJussila A, Zhang B, Kirti S, Wyetzner R, Reynolds C, Steele M, Hamburg-Shields E, Horsley V, Atit R. 124 Wnt signaling activation causes ATGL-dependent lipolysis in skin fibrosis. Journal Of Investigative Dermatology 2022, 142: s21. DOI: 10.1016/j.jid.2022.05.130.
784 Metabolic crosstalk in the wound bed: How adipocytes and immune cells communicate during wound healingForni M, Xu T, Krause W, Pannone R, Kibbey R, Rudolph M, Horsley V. 784 Metabolic crosstalk in the wound bed: How adipocytes and immune cells communicate during wound healing. Journal Of Investigative Dermatology 2022, 142: s136. DOI: 10.1016/j.jid.2022.05.797.
791 Dendritic cells express the receptor Axl in wound healingJustynski O, Horsley V. 791 Dendritic cells express the receptor Axl in wound healing. Journal Of Investigative Dermatology 2022, 142: s137. DOI: 10.1016/j.jid.2022.05.804.
Cut out that YAPping: Mechanisms to reduce scar formation.Horsley V. Cut out that YAPping: Mechanisms to reduce scar formation. Cell Stem Cell 2022, 29: 179-181. PMID: 35120615, DOI: 10.1016/j.stem.2022.01.005.
Single cell transcriptomic landscape of diabetic foot ulcersTheocharidis G, Thomas BE, Sarkar D, Mumme HL, Pilcher WJR, Dwivedi B, Sandoval-Schaefer T, Sîrbulescu RF, Kafanas A, Mezghani I, Wang P, Lobao A, Vlachos IS, Dash B, Hsia HC, Horsley V, Bhasin SS, Veves A, Bhasin M. Single cell transcriptomic landscape of diabetic foot ulcers. Nature Communications 2022, 13: 181. PMID: 35013299, PMCID: PMC8748704, DOI: 10.1038/s41467-021-27801-8.
Skin Fibrosis and Recovery Is Dependent on Wnt Activation via DPP4Jussila AR, Zhang B, Caves E, Kirti S, Steele M, Hamburg-Shields E, Lydon J, Ying Y, Lafyatis R, Rajagopalan S, Horsley V, Atit RP. Skin Fibrosis and Recovery Is Dependent on Wnt Activation via DPP4. Journal Of Investigative Dermatology 2021, 142: 1597-1606.e9. PMID: 34808238, PMCID: PMC9120259, DOI: 10.1016/j.jid.2021.10.025.
Fibroblasts: Origins, definitions, and functions in health and diseasePlikus MV, Wang X, Sinha S, Forte E, Thompson SM, Herzog EL, Driskell RR, Rosenthal N, Biernaskie J, Horsley V. Fibroblasts: Origins, definitions, and functions in health and disease. Cell 2021, 184: 3852-3872. PMID: 34297930, PMCID: PMC8566693, DOI: 10.1016/j.cell.2021.06.024.
Research Techniques Made Simple: Scientific Communication using TwitterDaneshjou R, Shmuylovich L, Grada A, Horsley V. Research Techniques Made Simple: Scientific Communication using Twitter. Journal Of Investigative Dermatology 2021, 141: 1615-1621.e1. PMID: 34167718, DOI: 10.1016/j.jid.2021.03.026.
624 Langerhans cells promote revascularization and repair during skin wound healingWasko R, Xing Y, Sidhu I, Bridges K, Miller-Jensen K, Naik S, Horsley V. 624 Langerhans cells promote revascularization and repair during skin wound healing. Journal Of Investigative Dermatology 2021, 141: s108. DOI: 10.1016/j.jid.2021.02.653.
632 Adipocyte-derived fatty acids induce metabolic activation of macrophage differentiation in the wound bedForni M, Xu Y, Krause W, Pannone R, Horsley V. 632 Adipocyte-derived fatty acids induce metabolic activation of macrophage differentiation in the wound bed. Journal Of Investigative Dermatology 2021, 141: s110. DOI: 10.1016/j.jid.2021.02.661.
612 Wnt signaling induces fibrotic fat loss via DPP4 in skin fibrosisJussila A, Zhang B, Kirti S, Steele M, Hamburg E, Horsley V, Atit R. 612 Wnt signaling induces fibrotic fat loss via DPP4 in skin fibrosis. Journal Of Investigative Dermatology 2021, 141: s106. DOI: 10.1016/j.jid.2021.02.641.
097 Adipose triglyceride lipase dependent adipocyte lipolysis inhibits dermal fibrosisCaves E, Lei V, Horsley V. 097 Adipose triglyceride lipase dependent adipocyte lipolysis inhibits dermal fibrosis. Journal Of Investigative Dermatology 2021, 141: s17. DOI: 10.1016/j.jid.2021.02.115.
The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiationCarley E, Stewart R, Zieman AG, Jalilian I, King DE, Zubek AE, Lin S, Horsley V, King MC. The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation. ELife 2021, 10: e58541. PMID: 33779546, PMCID: PMC8051949, DOI: 10.7554/elife.58541.
Statement on Racial EqualityGlass D, Gonzalez GR, Horsley V, Linos E. Statement on Racial Equality. Journal Of Investigative Dermatology 2020, 140: 1485. PMID: 32709273, PMCID: PMC7839962, DOI: 10.1016/j.jid.2020.06.009.
766 Keratinocyte differentiation is coupled to mechanical cues through the LINC complexZieman A, Stewart R, Zubek A, Carley E, Jalilian I, King M, Horsley V. 766 Keratinocyte differentiation is coupled to mechanical cues through the LINC complex. Journal Of Investigative Dermatology 2020, 140: s101. DOI: 10.1016/j.jid.2020.03.780.
Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin RepairShook BA, Wasko RR, Mano O, Rutenberg-Schoenberg M, Rudolph MC, Zirak B, Rivera-Gonzalez GC, López-Giráldez F, Zarini S, Rezza A, Clark DA, Rendl M, Rosenblum MD, Gerstein MB, Horsley V. Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair. Cell Stem Cell 2020, 26: 880-895.e6. PMID: 32302523, PMCID: PMC7853423, DOI: 10.1016/j.stem.2020.03.013.
Small-scale demixing in confluent biological tissuesSahu P, Sussman DM, Rübsam M, Mertz AF, Horsley V, Dufresne ER, Niessen CM, Marchetti MC, Manning ML, Schwarz JM. Small-scale demixing in confluent biological tissues. Soft Matter 2020, 16: 3325-3337. PMID: 32196025, DOI: 10.1039/c9sm01084j.
Skin in the Game: Stem Cells in Repair, Cancer, and HomeostasisHorsley V. Skin in the Game: Stem Cells in Repair, Cancer, and Homeostasis. Cell 2020, 181: 492-494. PMID: 32234524, DOI: 10.1016/j.cell.2020.03.019.
Regulated in Development and DNA Damage Responses 1 Prevents Dermal Adipocyte Differentiation and Is Required for Hair Cycle–Dependent Dermal Adipose ExpansionRivera-Gonzalez GC, Klopot A, Sabin K, Baida G, Horsley V, Budunova I. Regulated in Development and DNA Damage Responses 1 Prevents Dermal Adipocyte Differentiation and Is Required for Hair Cycle–Dependent Dermal Adipose Expansion. Journal Of Investigative Dermatology 2020, 140: 1698-1705.e1. PMID: 32032578, PMCID: PMC7398827, DOI: 10.1016/j.jid.2019.12.033.
Lifting Each Other Up: Epidermal Stem Cells in Tissue HomeostasisHorsley V. Lifting Each Other Up: Epidermal Stem Cells in Tissue Homeostasis. Developmental Cell 2019, 51: 296-298. PMID: 31689385, DOI: 10.1016/j.devcel.2019.10.013.
Diversity is Excellence: Initiatives in the Society for Investigative Dermatology to Broaden ParticipationHorsley V, Glass D, Minnillo R, Gallo R, Cruz P, Ward N. Diversity is Excellence: Initiatives in the Society for Investigative Dermatology to Broaden Participation. Journal Of Investigative Dermatology 2019, 139: 2217-2219. PMID: 31381893, DOI: 10.1016/j.jid.2019.07.695.
976 Knockout of mTOR/Akt inhibitor REDD1 results in hair cycle-independent dermal adipose expansion by promoting adipocyte differentiationGonzalez G, Klopot A, Sabin K, Baida G, Horsley V, Budunova I. 976 Knockout of mTOR/Akt inhibitor REDD1 results in hair cycle-independent dermal adipose expansion by promoting adipocyte differentiation. Journal Of Investigative Dermatology 2019, 139: s168. DOI: 10.1016/j.jid.2019.03.1052.
Thin Skinned: Aged Adipocyte Atrophy Impacts Innate ImmunityWasko RR, Horsley V. Thin Skinned: Aged Adipocyte Atrophy Impacts Innate Immunity. Trends In Immunology 2019, 40: 175-177. PMID: 30713009, DOI: 10.1016/j.it.2019.01.009.
Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repairShook BA, Wasko RR, Rivera-Gonzalez GC, Salazar-Gatzimas E, López-Giráldez F, Dash BC, Muñoz-Rojas AR, Aultman KD, Zwick RK, Lei V, Arbiser JL, Miller-Jensen K, Clark DA, Hsia HC, Horsley V. Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair. Science 2018, 362 PMID: 30467144, PMCID: PMC6684198, DOI: 10.1126/science.aar2971.
Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and DiseaseStewart R, King M, Horsley V. Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease. 2018, 263-292. DOI: 10.1007/978-3-319-16769-5_11.
Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactationZwick RK, Rudolph MC, Shook BA, Holtrup B, Roth E, Lei V, Van Keymeulen A, Seewaldt V, Kwei S, Wysolmerski J, Rodeheffer MS, Horsley V. Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation. Nature Communications 2018, 9: 3592. PMID: 30181538, PMCID: PMC6123393, DOI: 10.1038/s41467-018-05911-0.
Anatomical, Physiological, and Functional Diversity of Adipose TissueZwick RK, Guerrero-Juarez CF, Horsley V, Plikus MV. Anatomical, Physiological, and Functional Diversity of Adipose Tissue. Cell Metabolism 2018, 27: 68-83. PMID: 29320711, PMCID: PMC6050204, DOI: 10.1016/j.cmet.2017.12.002.
E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioningRübsam M, Mertz AF, Kubo A, Marg S, Jüngst C, Goranci-Buzhala G, Schauss AC, Horsley V, Dufresne ER, Moser M, Ziegler W, Amagai M, Wickström SA, Niessen CM. E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning. Nature Communications 2017, 8: 1250. PMID: 29093447, PMCID: PMC5665913, DOI: 10.1038/s41467-017-01170-7.
661 Mechanisms that regulate adipocyte stem cell behavior in the skinGonzalez G, Shook B, Holtrup B, Baida G, Budunova I, Rodeheffer M, Horsley V. 661 Mechanisms that regulate adipocyte stem cell behavior in the skin. Journal Of Investigative Dermatology 2017, 137: s306. DOI: 10.1016/j.jid.2017.07.338.
Interactions between Lymphangiogenesis and Angiogenesis During Dermal Wound HealingGrisotti G, Horsley V. Interactions between Lymphangiogenesis and Angiogenesis During Dermal Wound Healing. Journal Of The American College Of Surgeons 2017, 225: e88-e89. DOI: 10.1016/j.jamcollsurg.2017.07.763.
PDGFA regulation of dermal adipocyte stem cellsRivera-Gonzalez GC, Shook BA, Horsley V. PDGFA regulation of dermal adipocyte stem cells. Stem Cell Investigation 2017, 4: 72-72. PMID: 29057244, PMCID: PMC5639037, DOI: 10.21037/sci.2017.08.03.
Prdm1 Regulates Thymic Epithelial Function To Prevent AutoimmunityRoberts NA, Adams BD, McCarthy NI, Tooze RM, Parnell SM, Anderson G, Kaech SM, Horsley V. Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity. The Journal Of Immunology 2017, 199: 1250-1260. PMID: 28701508, PMCID: PMC5544928, DOI: 10.4049/jimmunol.1600941.
Tregs Expand the Skin Stem Cell NicheHorsley V, Naik S. Tregs Expand the Skin Stem Cell Niche. Developmental Cell 2017, 41: 455-456. PMID: 28586641, DOI: 10.1016/j.devcel.2017.05.020.
934 CD301b+ macrophages activate proliferation of CD29+;CD34+;Sca1+ fibroblasts through multiple secreted factors during wound healingShook B, Gonzalez G, Wasko R, Horsley V. 934 CD301b+ macrophages activate proliferation of CD29+;CD34+;Sca1+ fibroblasts through multiple secreted factors during wound healing. Journal Of Investigative Dermatology 2017, 137: s161. DOI: 10.1016/j.jid.2017.02.961.
Repeal and Replace: Adipocyte Regeneration in Wound RepairHorsley V, Watt F. Repeal and Replace: Adipocyte Regeneration in Wound Repair. Cell Stem Cell 2017, 20: 424-426. PMID: 28388424, DOI: 10.1016/j.stem.2017.03.015.
Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling AxisRivera-Gonzalez GC, Shook BA, Andrae J, Holtrup B, Bollag K, Betsholtz C, Rodeheffer MS, Horsley V. Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis. Cell Stem Cell 2016, 19: 738-751. PMID: 27746098, PMCID: PMC5135565, DOI: 10.1016/j.stem.2016.09.002.
Classical cadherins control polarized organization of junctions and cytoskeleton in stratified epitheliaRuebsam M, Kubo A, Mertz A, Boggetti B, Goranci G, Dufresne E, Horsley V, Amagai M, Niessen C. Classical cadherins control polarized organization of junctions and cytoskeleton in stratified epithelia. Journal Of Dermatological Science 2016, 84: e112. DOI: 10.1016/j.jdermsci.2016.08.338.
143 E-cadherin integrates EGFR signaling and mechanotransduction to control tissue polarization and barrier formationRübsam M, Mertz A, Kubo A, Dufresne E, Horsley V, Ziegler W, Wickström S, Amagai M, Niessen C. 143 E-cadherin integrates EGFR signaling and mechanotransduction to control tissue polarization and barrier formation. Journal Of Investigative Dermatology 2016, 136: s185. DOI: 10.1016/j.jid.2016.06.161.
CD301b+ Macrophages Are Essential for Effective Skin Wound HealingShook B, Xiao E, Kumamoto Y, Iwasaki A, Horsley V. CD301b+ Macrophages Are Essential for Effective Skin Wound Healing. Journal Of Investigative Dermatology 2016, 136: 1885-1891. PMID: 27287183, PMCID: PMC5727894, DOI: 10.1016/j.jid.2016.05.107.
The Role of Adipocytes in Tissue Regeneration and Stem Cell NichesShook B, Rivera Gonzalez G, Ebmeier S, Grisotti G, Zwick R, Horsley V. The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches. Annual Review Of Cell And Developmental Biology 2016, 32: 1-23. PMID: 27146311, PMCID: PMC5157158, DOI: 10.1146/annurev-cellbio-111315-125426.
741 Identification of a specific subset of monocytes/macrophages that coordinates skin wound healingShook B, Iwasaki A, Horsley V. 741 Identification of a specific subset of monocytes/macrophages that coordinates skin wound healing. Journal Of Investigative Dermatology 2016, 136: s131. DOI: 10.1016/j.jid.2016.02.784.
743 Adipocyte stem cells are maintained by Pdgfα signaling in the skinGonzalez G, Shook B, Holtrup B, Rodeheffer M, Horsley V. 743 Adipocyte stem cells are maintained by Pdgfα signaling in the skin. Journal Of Investigative Dermatology 2016, 136: s131. DOI: 10.1016/j.jid.2016.02.786.
430 Tissue polarization of mechano-adhesive signals, cytoskeleton and EGFR signaling controls skin barrier formationRuebsam M, Mertz A, Goranci G, Horsley V, Dufresne E, Ziegler W, Kubo A, Amagai M, Niessen C. 430 Tissue polarization of mechano-adhesive signals, cytoskeleton and EGFR signaling controls skin barrier formation. Journal Of Investigative Dermatology 2016, 136: s76. DOI: 10.1016/j.jid.2016.02.465.
748 The contribution of pre-existing adipocytes to skin wound healingShook B, Horsley V. 748 The contribution of pre-existing adipocytes to skin wound healing. Journal Of Investigative Dermatology 2016, 136: s132. DOI: 10.1016/j.jid.2016.02.791.
Montagna Symposium 2015: Harnessing Stem Cells to Reveal Novel Skin Biology and Disease TreatmentsHorsley V, Kulesz-Martin M, Wang XJ. Montagna Symposium 2015: Harnessing Stem Cells to Reveal Novel Skin Biology and Disease Treatments. Journal Of Investigative Dermatology 2016, 136: 893-896. PMID: 27107373, PMCID: PMC5572212, DOI: 10.1016/j.jid.2016.01.022.
Pigment epithelium‐derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockadeBelinsky GS, Sreekumar B, Andrejecsk JW, Saltzman WM, Gong J, Herzog RI, Lin S, Horsley V, Carpenter TO, Chung C. Pigment epithelium‐derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade. The FASEB Journal 2016, 30: 2837-2848. PMID: 27127101, PMCID: PMC4970601, DOI: 10.1096/fj.201500027r.
Origin of fibrosing cells in systemic sclerosisEbmeier S, Horsley V. Origin of fibrosing cells in systemic sclerosis. Current Opinion In Rheumatology 2015, 27: 555-562. PMID: 26352735, PMCID: PMC4639394, DOI: 10.1097/bor.0000000000000217.
Dermal white adipose tissue: a new component of the thermogenic responseAlexander CM, Kasza I, Yen CL, Reeder SB, Hernando D, Gallo RL, Jahoda CA, Horsley V, MacDougald OA. Dermal white adipose tissue: a new component of the thermogenic response. Journal Of Lipid Research 2015, 56: 2061-2069. PMID: 26405076, PMCID: PMC4617393, DOI: 10.1194/jlr.r062893.
Edges of human embryonic stem cell colonies display distinct mechanical properties and differentiation potentialRosowski KA, Mertz AF, Norcross S, Dufresne ER, Horsley V. Edges of human embryonic stem cell colonies display distinct mechanical properties and differentiation potential. Scientific Reports 2015, 5: 14218. PMID: 26391588, PMCID: PMC4585749, DOI: 10.1038/srep14218.
Loss of endogenous Nfatc1 reduces the rate of DMBA/TPA-induced skin tumorigenesisGoldstein J, Roth E, Roberts N, Zwick R, Lin S, Fletcher S, Tadeu A, Wu C, Beck A, Zeiss C, Suárez-Fariñas M, Horsley V. Loss of endogenous Nfatc1 reduces the rate of DMBA/TPA-induced skin tumorigenesis. Molecular Biology Of The Cell 2015, 26: 3606-3614. PMID: 26310443, PMCID: PMC4603931, DOI: 10.1091/mbc.e15-05-0282.
Nuclear–cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesionsStewart RM, Zubek AE, Rosowski KA, Schreiner SM, Horsley V, King MC. Nuclear–cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions. Journal Of Cell Biology 2015, 209: 403-418. PMID: 25963820, PMCID: PMC4427780, DOI: 10.1083/jcb.201502024.
Transcriptional Profiling of Ectoderm Specification to Keratinocyte Fate in Human Embryonic Stem CellsTadeu AM, Lin S, Hou L, Chung L, Zhong M, Zhao H, Horsley V. Transcriptional Profiling of Ectoderm Specification to Keratinocyte Fate in Human Embryonic Stem Cells. PLOS ONE 2015, 10: e0122493. PMID: 25849374, PMCID: PMC4388500, DOI: 10.1371/journal.pone.0122493.
Defining dermal adipose tissueDriskell RR, Jahoda CA, Chuong C, Watt FM, Horsley V. Defining dermal adipose tissue. Experimental Dermatology 2014, 23: 629-631. PMID: 24841073, PMCID: PMC4282701, DOI: 10.1111/exd.12450.
Developing stratified epithelia: lessons from the epidermis and thymusRoberts N, Horsley V. Developing stratified epithelia: lessons from the epidermis and thymus. WIREs Mechanisms Of Disease 2014, 3: 389-402. PMID: 25176390, PMCID: PMC4283209, DOI: 10.1002/wdev.146.
Pygo2 regulates β-catenin–induced activation of hair follicle stem/progenitor cells and skin hyperplasiaSun P, Watanabe K, Fallahi M, Lee B, Afetian ME, Rheaume C, Wu D, Horsley V, Dai X. Pygo2 regulates β-catenin–induced activation of hair follicle stem/progenitor cells and skin hyperplasia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 10215-10220. PMID: 24982158, PMCID: PMC4104891, DOI: 10.1073/pnas.1311395111.
Characterization of Cre recombinase models for the study of adipose tissueJeffery E, Berry R, Church CD, Yu S, Shook BA, Horsley V, Rosen ED, Rodeheffer MS. Characterization of Cre recombinase models for the study of adipose tissue. Adipocyte 2014, 3: 206-211. PMID: 25068087, PMCID: PMC4110097, DOI: 10.4161/adip.29674.
Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactationGoldstein J, Fletcher S, Roth E, Wu C, Chun A, Horsley V. Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation. Genes & Development 2014, 28: 983-994. PMID: 24732379, PMCID: PMC4018496, DOI: 10.1101/gad.236554.113.
Adipocytes in Skin Health and DiseaseRivera-Gonzalez G, Shook B, Horsley V. Adipocytes in Skin Health and Disease. Cold Spring Harbor Perspectives In Medicine 2014, 4: a015271. PMID: 24591537, PMCID: PMC3935392, DOI: 10.1101/cshperspect.a015271.
Chapter Four Epithelial Stem Cells in Adult SkinTadeu AM, Horsley V. Chapter Four Epithelial Stem Cells in Adult Skin. 2014, 107: 109-131. PMID: 24439804, PMCID: PMC5595246, DOI: 10.1016/b978-0-12-416022-4.00004-4.
Notch signaling represses p63 expression in the developing surface ectodermTadeu AM, Horsley V. Notch signaling represses p63 expression in the developing surface ectoderm. Development 2013, 140: 3777-3786. PMID: 23924630, PMCID: PMC3754476, DOI: 10.1242/dev.093948.
Intradermal adipocytes mediate fibroblast recruitment during skin wound healingSchmidt BA, Horsley V. Intradermal adipocytes mediate fibroblast recruitment during skin wound healing. Development 2013, 140: 1517-1527. PMID: 23482487, PMCID: PMC3596993, DOI: 10.1242/dev.087593.
Cadherin-based intercellular adhesions organize epithelial cell–matrix traction forcesMertz AF, Che Y, Banerjee S, Goldstein JM, Rosowski KA, Revilla SF, Niessen CM, Marchetti MC, Dufresne ER, Horsley V. Cadherin-based intercellular adhesions organize epithelial cell–matrix traction forces. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 110: 842-847. PMID: 23277553, PMCID: PMC3549115, DOI: 10.1073/pnas.1217279110.
IL-22 Promotes Fibroblast-Mediated Wound Repair in the SkinMcGee HM, Schmidt BA, Booth CJ, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA, Horsley V. IL-22 Promotes Fibroblast-Mediated Wound Repair in the Skin. Journal Of Investigative Dermatology 2012, 133: 1321-1329. PMID: 23223145, PMCID: PMC3610794, DOI: 10.1038/jid.2012.463.
Unravelling hair follicle–adipocyte communicationSchmidt B, Horsley V. Unravelling hair follicle–adipocyte communication. Experimental Dermatology 2012, 21: 827-830. PMID: 23163647, PMCID: PMC3507425, DOI: 10.1111/exd.12001.
Development and homeostasis of the sebaceous glandNiemann C, Horsley V. Development and homeostasis of the sebaceous gland. Seminars In Cell And Developmental Biology 2012, 23: 928-936. PMID: 22960253, PMCID: PMC5595243, DOI: 10.1016/j.semcdb.2012.08.010.
Split decisions: oesophageal progenitor cell behaviourHorsley V. Split decisions: oesophageal progenitor cell behaviour. The EMBO Journal 2012, 31: 3653-3654. PMID: 22885597, PMCID: PMC3442277, DOI: 10.1038/emboj.2012.230.
Scaling of Traction Forces with the Size of Cohesive Cell ColoniesMertz AF, Banerjee S, Che Y, German GK, Xu Y, 徐晔, Hyland C, Marchetti M, Horsley V, Dufresne E. Scaling of Traction Forces with the Size of Cohesive Cell Colonies. Physical Review Letters 2012, 108: 198101. PMID: 23003091, PMCID: PMC4098718, DOI: 10.1103/physrevlett.108.198101.
Home sweet home: skin stem cell nichesGoldstein J, Horsley V. Home sweet home: skin stem cell niches. Cellular And Molecular Life Sciences 2012, 69: 2573-2582. PMID: 22410738, PMCID: PMC3449145, DOI: 10.1007/s00018-012-0943-3.
Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair CyclingFesta E, Fretz J, Berry R, Schmidt B, Rodeheffer M, Horowitz M, Horsley V. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling. Cell 2011, 146: 761-771. PMID: 21884937, PMCID: PMC3298746, DOI: 10.1016/j.cell.2011.07.019.
Upward bound: follicular stem cell fate decisionsHorsley V. Upward bound: follicular stem cell fate decisions. The EMBO Journal 2011, 30: 2986-2987. PMID: 21811300, PMCID: PMC3160195, DOI: 10.1038/emboj.2011.231.
Ferreting out stem cells from their nichesFuchs E, Horsley V. Ferreting out stem cells from their niches. Nature Cell Biology 2011, 13: 513-518. PMID: 21540847, PMCID: PMC3289407, DOI: 10.1038/ncb0511-513.
Epigenetics, Wnt signaling, and stem cells: the Pygo2 connectionHorsley V. Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection. Journal Of Cell Biology 2009, 185: 761-763. PMID: 19487452, PMCID: PMC2711585, DOI: 10.1083/jcb.200904125.
FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1Norrmén C, Ivanov K, Cheng J, Zangger N, Delorenzi M, Jaquet M, Miura N, Puolakkainen P, Horsley V, Hu J, Augustin H, Ylä-Herttuala S, Alitalo K, Petrova T. FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. Journal Of Experimental Medicine 2009, 206: i10-i10. DOI: 10.1084/jem2065oia10.
FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1Norrmén C, Ivanov KI, Cheng J, Zangger N, Delorenzi M, Jaquet M, Miura N, Puolakkainen P, Horsley V, Hu J, Augustin HG, Ylä-Herttuala S, Alitalo K, Petrova TV. FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. Journal Of Cell Biology 2009, 185: 439-457. PMID: 19398761, PMCID: PMC2700385, DOI: 10.1083/jcb.200901104.
Valerie Horsley: getting under the skin. Interview by Ben Short.Horsley V. Valerie Horsley: getting under the skin. Interview by Ben Short. The Journal Of Cell Biology 2009, 184: 466-7. PMID: 19237594, PMCID: PMC2654133, DOI: 10.1083/jcb.1844pi.
Beauty is skin deep: imaging and characterization of skin stem cellsPasolli H, Horsley V, Tumbar T, Blanpain C, Lowry W, Greco V, Fuchs E. Beauty is skin deep: imaging and characterization of skin stem cells. Microscopy And Microanalysis 2008, 14: 1468-1469. DOI: 10.1017/s1431927608085565.
More than one way to skin . . .Fuchs E, Horsley V. More than one way to skin . . . Genes & Development 2008, 22: 976-985. PMID: 18413712, PMCID: PMC2732395, DOI: 10.1101/gad.1645908.
NFATc1 Balances Quiescence and Proliferation of Skin Stem CellsHorsley V, Aliprantis AO, Polak L, Glimcher LH, Fuchs E. NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells. Cell 2008, 132: 299-310. PMID: 18243104, PMCID: PMC2546702, DOI: 10.1016/j.cell.2007.11.047.
Reprogramming somatic cells to their embryonic stateHorsley V, Fuchs E. Reprogramming somatic cells to their embryonic state. All Life 2007, 1: 89-93. PMID: 19404413, PMCID: PMC2639841, DOI: 10.2976/1.2757614.
Epithelial Stem Cells: Turning over New LeavesBlanpain C, Horsley V, Fuchs E. Epithelial Stem Cells: Turning over New Leaves. Cell 2007, 128: 445-458. PMID: 17289566, PMCID: PMC2408375, DOI: 10.1016/j.cell.2007.01.014.
Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous GlandHorsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, Nussenzweig M, Tarakhovsky A, Fuchs E. Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland. Cell 2006, 126: 597-609. PMID: 16901790, PMCID: PMC2424190, DOI: 10.1016/j.cell.2006.06.048.
Forming a multinucleated cell: molecules that regulate myoblast fusion.Horsley V, Pavlath GK. Forming a multinucleated cell: molecules that regulate myoblast fusion. Cells, Tissues, Organs 2004, 176: 67-78. PMID: 14745236, DOI: 10.1159/000075028.
Cell fusion in skeletal muscle--central role of NFATC2 in regulating muscle cell size.Pavlath GK, Horsley V. Cell fusion in skeletal muscle--central role of NFATC2 in regulating muscle cell size. Cell Cycle (Georgetown, Tex.) 2003, 2: 420-3. PMID: 12963831.
IL-4 acts as a myoblast recruitment factor during mammalian muscle growth.Horsley V, Jansen KM, Mills ST, Pavlath GK. IL-4 acts as a myoblast recruitment factor during mammalian muscle growth. Cell 2003, 113: 483-94. PMID: 12757709, DOI: 10.1016/s0092-8674(03)00319-2.
Prostaglandin F2(alpha) stimulates growth of skeletal muscle cells via an NFATC2-dependent pathway.Horsley V, Pavlath GK. Prostaglandin F2(alpha) stimulates growth of skeletal muscle cells via an NFATC2-dependent pathway. The Journal Of Cell Biology 2003, 161: 111-8. PMID: 12695501, PMCID: PMC2172881, DOI: 10.1083/jcb.200208085.
NFAT: ubiquitous regulator of cell differentiation and adaptation.Horsley V, Pavlath GK. NFAT: ubiquitous regulator of cell differentiation and adaptation. The Journal Of Cell Biology 2002, 156: 771-4. PMID: 11877454, PMCID: PMC2173310, DOI: 10.1083/jcb.200111073.
Regulation of the growth of multinucleated muscle cells by an NFATC2-dependent pathway.Horsley V, Friday BB, Matteson S, Kegley KM, Gephart J, Pavlath GK. Regulation of the growth of multinucleated muscle cells by an NFATC2-dependent pathway. The Journal Of Cell Biology 2001, 153: 329-38. PMID: 11309414, PMCID: PMC2169453, DOI: 10.1083/jcb.153.2.329.
Calcineurin activity is required for the initiation of skeletal muscle differentiation.Friday BB, Horsley V, Pavlath GK. Calcineurin activity is required for the initiation of skeletal muscle differentiation. The Journal Of Cell Biology 2000, 149: 657-66. PMID: 10791979, PMCID: PMC2174840, DOI: 10.1083/jcb.149.3.657.

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