Peter Cresswell, PhD, FRS
Research & Publications
Biography
News
Research Summary
MHC class I molecules in the endoplasmic reticulum (ER) bind antigenic peptides translocated from the cytosol by the Transporters associated with Antigen Processing (TAP). The assembly of a class I molecule involves two chaperones, calnexin and calreticulin, and the thiol oxido-reductase, ERp57. Calreticulin- and ERp57-associated class I molecules physically associate with TAP molecules, with another protein, tapasin, serving as a bridge. Peptide binding releases the class I molecules from the “peptide loading complex”, and a disulfide-linked dimer of tapasin and ERp57 within the complex catalyzes peptide loading. The peptides can come from extracellular proteins in the case of dendritic cells, a process called cross-presentation. Calnexin, calreticulin and ERp57 are also involved in the assembly of CD1d molecules, which bind lipids.
MHC class II molecules form a complex in the ER with the invariant chain. This complex is targeted to lysosomes where invariant chain is degraded and a residual fragment eliminated by HLA-DM, allowing peptide binding. A gamma interferon-inducible lysosomal thiol reductase (GILT) plays a role in peptide generation, shown using a GILT “knock-out” mouse. Reduction of disulfide bonds by GILT helps unfold protein antigens to MHC class II molecules. Recent work has shown that cross-presentation of disulfide-containing antigens can be facilitated by GILT.
Other work centers on antiviral mechanisms of proteins inducible by interferons. The interferon-inducible viperin protein plays a role in resistance to influenza virus.
Specialized Terms: Molecular mechanisms of antigen processing; Assembly and intracellular transport of CD1 molecules, Class I and Class II MHC molecules; Effector functions; mechanisms of action of interferon-induced proteins; Viral immunity
Extensive Research Description
The main interests of this laboratory are in two areas; antigen processing and the mechanisms of action of antiviral proteins stimulated by interferons. Studies of MHC class I molecules center onto problems. The first is the mechanism(s) governing the association of antigen-derived peptides with class I molecules in the endoplasmic reticulum (ER). Peptides are transported into the ER by the Transporter associated with Antigen Processing (TAP) after their generation from cytosolic proteins by proteasomal degradation. Peptide binding occurs in the context of the peptide loading complex, which consists of TAP, an associated transmembrane glycoprotein called tapasin, and an associated 'empty' class I molecule which is a heterodimer of the class I heavy chain and ß2microglobulin. Also in the complex are two housekeeping molecules, the chaperone calreticulin which associates with the glycan on the class I heavy chain, and ERp57, a thiol oxidoreductase that is disulfide linked to tapasin. How the peptide loading complex promotes peptide loading of class I molecules at the molecular level is under intensive investigation, but it is clear that the tapasin-ERp57 heterodimer is critically involved in peptide binding and the process of peptide editing, which ensures that MHC class I molecules associate with peptides of the highest affinity before leaving the ER for the cell surface.
The second area of interest in MHC class I lies in the phenomenon of cross-presentation, which is essential for priming the response of naïve CD8-positive T cells to viral antigens in vivo. Cross-presentation is a particular property of dendritic cells that allows them to generate MHC class I complexes with peptides derived from protein antigens that are internalized by phagocytosis or pinocytosis. These two processes ultimately allow entry of external proteins into the cytosol, either by crossing the phagosomal membrane or the ER membrane after they gain access to the ER. The mechanisms allowing protein access to the ER and the translocation mechanism responsible for entry into the cytosol are two problems being studied. Recent work shows that unfolding of the antigenic protein in the endocytic pathway facilitates its translocation into the cytosol. If the protein contains disulfide bonds reduction by Gamma interferon-inducible lysosomal thiol reductase (GILT) may be required.
Work on MHC class II currently focuses on the role of GILT in MHC class II-restricted antigen processing. The latter is important for the recognition by CD4-positive T cells of protein antigens containing disulfide bonds, demonstrated in a GILT knockout mouse.
A third area of interest within the antigen processing field centers on CD1d molecules, which are structurally similar to MHC class I molecules but bind lipids rather than peptides. We are trying to understand the role of lipid binding and of ER chaperones in the assembly of CD1 molecules, as well as the precise mechanisms governing lipid binding in endosomes and lysosomes. We have shown that saposins, small molecules essential for the degradation of sphingolipids, are required for lipid binding to CD1d molecules in the endocytic pathway. Saposins are capable of mobilizing monomeric lipid molecules from the endosomal or lysosomal bilayer which then allows them to bind to theCD1d molecules. The importance of CD1d in antiviral responses is highlighted by the efforts made by a number of viruses to reduce CD1dexpression upon infection. We found that Herpes simplexvirus-1 (HSV-1) does this by inhibiting CD1d re-expression on the surface of cells during recycling through the endosomal/lysosomal system. Upon HSV-1 infection, CD1d molecules accumulate in lysosomes and disappear from the cell surface.
Finally, we are interested in understanding the functions of interferon-inducible proteins, particularly a protein we identified and called viperin which inhibits the growth of a number of viruses, including influenza virus. We originally showed that viperin has an inhibitory effect on the growth of human cytomegalovirus (CMV), even though it is induced by CMV upon infection. Viperin is relocalized by a CMV-encoded protein to mitochondria, where it has an effect on cellular metabolism that facilitates CMV replication. We have recently collaboratively determined the crystallographic structure of viperin.
Coauthors
Research Interests
Biology; Cell Biology; Endoplasmic Reticulum; Immunity; Major Histocompatibility Complex
Selected Publications
- CMPK2 restricts Zika virus replication by inhibiting viral translationPawlak J, Hsu J, Xia H, Han P, Suh H, Grove T, Morrison J, Shi P, Cresswell P, Laurent-Rolle M. CMPK2 restricts Zika virus replication by inhibiting viral translation PLOS Pathogens 2023, 19: e1011286. PMID: 37075076, PMCID: PMC10150978, DOI: 10.1371/journal.ppat.1011286.
- SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expressionArshad N, Laurent-Rolle M, Ahmed W, Hsu J, Mitchell S, Pawlak J, Sengupta D, Biswas K, Cresswell P. SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2208525120. PMID: 36574644, PMCID: PMC9910621, DOI: 10.1073/pnas.2208525120.
- Poster session 1Roles of calreticulin and its mutants associated with MPN disorders in immune responsesArshad N, Cresswell P. Poster session 1Roles of calreticulin and its mutants associated with MPN disorders in immune responses Molecular Immunology 2022, 150: 11. DOI: 10.1016/j.molimm.2022.05.044.
- A novel probe to assess cytosolic entry of exogenous proteinsLu Q, Jiang Y, Grotzke J, Saltzman M, Cresswell P. A novel probe to assess cytosolic entry of exogenous proteins Molecular Immunology 2022, 150: 28. DOI: 10.1016/j.molimm.2022.05.096.
- Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentationJiang J, Taylor DK, Kim EJ, Boyd LF, Ahmad J, Mage MG, Truong HV, Woodward CH, Sgourakis NG, Cresswell P, Margulies DH, Natarajan K. Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation Nature Communications 2022, 13: 5470. PMID: 36115831, PMCID: PMC9482634, DOI: 10.1038/s41467-022-33153-8.
- Abstract 1379: Discovery of tumor-associated, immunogenic peptides presented in a patient-derived, mutant calreticulin-driven myeloproliferative neoplasm cell lineArshad N, Vigneron N, Bozkus C, Stroobant V, Naulaerts S, Bhardwaj N, Van den Eynde B, Cresswell P. Abstract 1379: Discovery of tumor-associated, immunogenic peptides presented in a patient-derived, mutant calreticulin-driven myeloproliferative neoplasm cell line Cancer Research 2022, 82: 1379-1379. DOI: 10.1158/1538-7445.am2022-1379.
- Translational regulation of viral RNA in the type I interferon responseHsu J, Laurent-Rolle M, Cresswell P. Translational regulation of viral RNA in the type I interferon response Current Research In Virological Science 2021, 2: 100012. DOI: 10.1016/j.crviro.2021.100012.
- Abstract B163: Regulation of translation by the interferon-induced antiviral protein viperinHsu C, Laurent-Rolle M, Cresswell P. Abstract B163: Regulation of translation by the interferon-induced antiviral protein viperin Cancer Immunology Research 2019, 7: b163-b163. DOI: 10.1158/2326-6074.cricimteatiaacr18-b163.
- Antigen Processing and Presentation Mechanisms in Myeloid CellsRoche P, Cresswell P. Antigen Processing and Presentation Mechanisms in Myeloid Cells 2017, 209-223. DOI: 10.1128/9781555819194.ch11.
- Abstract B059: Slow maturation of early phagosomes promotes a TAP independent antigen cross-presentation pathwaySengupta D, Cresswell P. Abstract B059: Slow maturation of early phagosomes promotes a TAP independent antigen cross-presentation pathway Cancer Immunology Research 2016, 4: b059-b059. DOI: 10.1158/2326-6074.cricimteatiaacr15-b059.
- A congenital disorder of deglycosylation: biochemical characterization of N‐glycanase 1 deficiency in patient fibroblasts (607.3)He P, Ng B, Cresswell P, Grotzke J, Gunel M, Jafar‐Nejad H, Kodali V, Kaufman R, Freeze H. A congenital disorder of deglycosylation: biochemical characterization of N‐glycanase 1 deficiency in patient fibroblasts (607.3) The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.607.3.
- A multi-dimensional RNAi screen reveals pathways controlling MHC Class II antigen presentationPaul P, van den Hoorn T, Jongsma M, Janssen L, Cresswell P, van Ham M, Brinke A, Kuijl C, Neefjes J. A multi-dimensional RNAi screen reveals pathways controlling MHC Class II antigen presentation Molecular Immunology 2012, 51: 27. DOI: 10.1016/j.molimm.2012.02.073.
- Combined functional and kinetic measurements to address the role of saposins in loading CD1d molecules with iNKT cell agonistsSalio M, Ghadbane H, Shepherd D, Cypen J, Aichinger M, Jervis P, Besra G, Cresswell P, Cerundolo V. Combined functional and kinetic measurements to address the role of saposins in loading CD1d molecules with iNKT cell agonists Molecular Immunology 2012, 51: 38-39. DOI: 10.1016/j.molimm.2012.02.116.
- TAP-independent presentation of the melanoma vaccine candidate epitope gp100209-217 requires no gp100 sequences outside the core peptide and is sensitive to cytosolic TPP2 degradation (100.2)Leonhardt R, Vigneron N, Van den Eynde B, Cresswell P. TAP-independent presentation of the melanoma vaccine candidate epitope gp100209-217 requires no gp100 sequences outside the core peptide and is sensitive to cytosolic TPP2 degradation (100.2) The Journal Of Immunology 2011, 186: 100.2-100.2. DOI: 10.4049/jimmunol.186.supp.100.2.
- Mechanism of Disulfide Reduction by the Acidophilic Reductase Enzyme GILTKosuri P, Chen B, Lim E, Reinisch K, Cresswell P, Fernandez J. Mechanism of Disulfide Reduction by the Acidophilic Reductase Enzyme GILT Biophysical Journal 2010, 98: 449a-450a. DOI: 10.1016/j.bpj.2009.12.2444.
- Abstract 1338: The Role of the Estrogen Receptor 46 Hydrophobic Domain on Endothelial Membrane-initiated SignalingKim K, Li L, Hisamoto K, Stepensky D, Cresswell P, Bender J. Abstract 1338: The Role of the Estrogen Receptor 46 Hydrophobic Domain on Endothelial Membrane-initiated Signaling Circulation 2007, 116 DOI: 10.1161/circ.116.suppl_16.ii_274-a.
- Charles A. Janeway, Jr. (1943-2003)Bottomly K, Cresswell P, Flavell R, Ghosh S, Pober J, Schatz D. Charles A. Janeway, Jr. (1943-2003) Immunity 2003, 18: 591-592. DOI: 10.1016/s1074-7613(03)00123-7.
- Charles A. Janeway, Jr. (1943-2003)Bottomly K, Cresswell P, Flavell R, Ghosh S, Pober J, Schatz D. Charles A. Janeway, Jr. (1943-2003) Cell 2003, 113: 433-434. DOI: 10.1016/s0092-8674(03)00361-1.
- A specific glycoform of MHC1 is required for the formation of the multimolecular complex involved in the assembly of the MHC1:peptide complexesRadcliffe C, Diedrich G, Dwek R, Rudd P, Cresswell P. A specific glycoform of MHC1 is required for the formation of the multimolecular complex involved in the assembly of the MHC1:peptide complexes Biochemical Society Transactions 2002, 30: a29-a29. DOI: 10.1042/bst030a029a.
- Endothelial MHC-I-peptides specificity in IFN-gamma induced cytoprotection against natural killingKavokin A, Ayalon O, Marshall N, Pamer E, Cresswell P, Bender J. Endothelial MHC-I-peptides specificity in IFN-gamma induced cytoprotection against natural killing The Journal Of Heart And Lung Transplantation 2002, 21: 132. DOI: 10.1016/s1053-2498(01)00649-0.
- Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirusChin K, Cresswell P. Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 15125-15130. PMID: 11752458, PMCID: PMC64994, DOI: 10.1073/pnas.011593298.
- Defective Antigen Processing in GILT-Free MiceMaric M, Arunachalam B, Phan U, Dong C, Garrett W, Cannon K, Alfonso C, Karlsson L, Flavell R, Cresswell P. Defective Antigen Processing in GILT-Free Mice Science 2001, 294: 1361-1365. PMID: 11701933, DOI: 10.1126/science.1065500.
- Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimersSant'Angelo D, Cresswell P, Janeway C, Denzin L. Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 6824-6829. PMID: 11381132, PMCID: PMC34437, DOI: 10.1073/pnas.121179998.
- Distinct functions and cooperative interaction of the subunits of the transporter associated with antigen processing (TAP)Karttunen J, Lehner P, Gupta S, Hewitt E, Cresswell P. Distinct functions and cooperative interaction of the subunits of the transporter associated with antigen processing (TAP) Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 7431-7436. PMID: 11381133, PMCID: PMC34686, DOI: 10.1073/pnas.121180198.
- Quality control of transmembrane domain assembly in the tetraspanin CD82Cannon K, Cresswell P. Quality control of transmembrane domain assembly in the tetraspanin CD82 The EMBO Journal 2001, 20: 2443-2453. PMID: 11350933, PMCID: PMC125455, DOI: 10.1093/emboj/20.10.2443.
- Multiple species express thiol oxidoreductases related to GILTPhan U, Maric M, Dick T, Cresswell P. Multiple species express thiol oxidoreductases related to GILT Immunogenetics 2001, 53: 342-346. PMID: 11491538, DOI: 10.1007/s002510100323.
- Cathepsin S Regulates the Expression of Cathepsin L and the Turnover of γ-Interferon-inducible Lysosomal Thiol Reductase in B Lymphocytes*Honey K, Duff M, Beers C, Brissette W, Elliott E, Peters C, Maric M, Cresswell P, Rudensky A. Cathepsin S Regulates the Expression of Cathepsin L and the Turnover of γ-Interferon-inducible Lysosomal Thiol Reductase in B Lymphocytes* Journal Of Biological Chemistry 2001, 276: 22573-22578. PMID: 11306582, DOI: 10.1074/jbc.m101851200.
- Glycosylation and the Immune SystemRudd P, Elliott T, Cresswell P, Wilson I, Dwek R. Glycosylation and the Immune System Science 2001, 291: 2370-2376. PMID: 11269318, DOI: 10.1126/science.291.5512.2370.
- A Role for Calnexin in the Assembly of the MHC Class I Loading Complex in the Endoplasmic ReticulumDiedrich G, Bangia N, Pan M, Cresswell P. A Role for Calnexin in the Assembly of the MHC Class I Loading Complex in the Endoplasmic Reticulum The Journal Of Immunology 2001, 166: 1703-1709. PMID: 11160214, DOI: 10.4049/jimmunol.166.3.1703.
- Antigen processing and recognitionCresswell P, Lanzavecchia A. Antigen processing and recognition Current Opinion In Immunology 2001, 13: 11-12. PMID: 11154910, DOI: 10.1016/s0952-7915(00)00174-6.
- Gamma-Interferon-inducibleLysosomal Thiol Reductase (GILT) MATURATION, ACTIVITY, AND MECHANISM OF ACTION*Phan U, Arunachalam B, Cresswell P. Gamma-Interferon-inducibleLysosomal Thiol Reductase (GILT) MATURATION, ACTIVITY, AND MECHANISM OF ACTION* Journal Of Biological Chemistry 2000, 275: 25907-25914. PMID: 10852914, DOI: 10.1074/jbc.m003459200.
- Interaction of Human Immunodeficiency Virus Type 2 Vpx and Invariant ChainPancio H, Heyden N, Kosuri K, Cresswell P, Ratner L. Interaction of Human Immunodeficiency Virus Type 2 Vpx and Invariant Chain Journal Of Virology 2000, 74: 6168-6172. PMID: 10846101, PMCID: PMC112116, DOI: 10.1128/jvi.74.13.6168-6172.2000.
- Intracellular Surveillance: Controlling the Assembly of MHC Class I‐Peptide ComplexesCresswell P. Intracellular Surveillance: Controlling the Assembly of MHC Class I‐Peptide Complexes Traffic 2000, 1: 301-305. PMID: 11208114, DOI: 10.1034/j.1600-0854.2000.010402.x.
- Continuity and ChangeBottomly K, Cresswell P, Flavell R, Janeway C, Pober J. Continuity and Change Immunity 2000, 12: 119. DOI: 10.1016/s1074-7613(00)80164-8.
- Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT)Arunachalam B, Phan U, Geuze H, Cresswell P. Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT) Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 745-750. PMID: 10639150, PMCID: PMC15401, DOI: 10.1073/pnas.97.2.745.
- The nature of the MHC class I peptide loading complexCresswell P, Bangia N, Dick T, Diedrich G. The nature of the MHC class I peptide loading complex Immunological Reviews 1999, 172: 21-28. PMID: 10631934, DOI: 10.1111/j.1600-065x.1999.tb01353.x.
- Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cellsTomazin R, Boname J, Hegde N, Lewinsohn D, Altschuler Y, Jones T, Cresswell P, Nelson J, Riddell S, Johnson D. Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells Nature Medicine 1999, 5: 1039-1043. PMID: 10470081, DOI: 10.1038/12478.
- Thiol oxidation and reduction in MHC-restricted antigen processing and presentationCresswell P, Arunachalam B, Bangia N, Dick T, Diedrich G, Hughes E, Maric M. Thiol oxidation and reduction in MHC-restricted antigen processing and presentation Immunologic Research 1999, 19: 191. PMID: 10493173, DOI: 10.1007/bf02786487.
- The N‐terminal region of tapasin is required to stabilize the MHC class I loading complexBangia N, Lehner P, Hughes E, Surman M, Cresswell P. The N‐terminal region of tapasin is required to stabilize the MHC class I loading complex European Journal Of Immunology 1999, 29: 1858-1870. PMID: 10382748, DOI: 10.1002/(sici)1521-4141(199906)29:06<1858::aid-immu1858>3.0.co;2-c.
- Human epidermal Langerhans cells lack functional mannose receptors and a fully developed endosomal/lysosomal compartment for loading of HLA class II moleculesMommaas A, Mulder A, Jordens R, Out C, Tan M, Cresswell P, Kluin P, Koning F. Human epidermal Langerhans cells lack functional mannose receptors and a fully developed endosomal/lysosomal compartment for loading of HLA class II molecules European Journal Of Immunology 1999, 29: 571-580. PMID: 10064073, DOI: 10.1002/(sici)1521-4141(199902)29:02<571::aid-immu571>3.0.co;2-e.
- Antigen recognition Editorial overviewCresswell P, Howard J. Antigen recognition Editorial overview Current Opinion In Immunology 1999, 11: 61-63. PMID: 10084794, DOI: 10.1016/s0952-7915(99)80011-9.
- Elucidation of the genetic basis of the antigen presentation defects in the mutant cell line .220 reveals polymorphism and alternative splicing of the tapasin geneCopeman J, Bangia N, Cross J, Cresswell P. Elucidation of the genetic basis of the antigen presentation defects in the mutant cell line .220 reveals polymorphism and alternative splicing of the tapasin gene European Journal Of Immunology 1998, 28: 3783-3791. PMID: 9842921, DOI: 10.1002/(sici)1521-4141(199811)28:11<3783::aid-immu3783>3.0.co;2-9.
- The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules.Hammond C, Denzin L, Pan M, Griffith J, Geuze H, Cresswell P. The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules. The Journal Of Immunology 1998, 161: 3282-91. PMID: 9759843, DOI: 10.4049/jimmunol.161.7.3282.
- Assembly of MHC class I molecules with biosynthesized endoplasmic reticulum-targeted peptides is inefficient in insect cells and can be enhanced by protease inhibitors.Deng Y, Gibbs J, Bačík I, Porgador A, Copeman J, Lehner P, Ortmann B, Cresswell P, Bennink J, Yewdell J. Assembly of MHC class I molecules with biosynthesized endoplasmic reticulum-targeted peptides is inefficient in insect cells and can be enhanced by protease inhibitors. The Journal Of Immunology 1998, 161: 1677-85. PMID: 9712031, DOI: 10.4049/jimmunol.161.4.1677.
- Intracellular formation and cell surface expression of a complex of an intact lysosomal protein and MHC class II molecules.Arunachalam B, Pan M, Cresswell P. Intracellular formation and cell surface expression of a complex of an intact lysosomal protein and MHC class II molecules. The Journal Of Immunology 1998, 160: 5797-806. PMID: 9637490, DOI: 10.4049/jimmunol.160.12.5797.
- The thiol oxidoreductase ERp57 is a component of the MHC class I peptide-loading complexHughes E, Cresswell P. The thiol oxidoreductase ERp57 is a component of the MHC class I peptide-loading complex Current Biology 1998, 8: 709-713. PMID: 9637923, DOI: 10.1016/s0960-9822(98)70278-7.
- HLA-B27–Restricted Antigen Presentation in the Absence of Tapasin Reveals Polymorphism in Mechanisms of HLA Class I Peptide LoadingPeh C, Burrows S, Barnden M, Khanna R, Cresswell P, Moss D, McCluskey J. HLA-B27–Restricted Antigen Presentation in the Absence of Tapasin Reveals Polymorphism in Mechanisms of HLA Class I Peptide Loading Immunity 1998, 8: 531-542. PMID: 9620674, DOI: 10.1016/s1074-7613(00)80558-0.
- Proteases, processing, and thymic selection.Cresswell P. Proteases, processing, and thymic selection. Science 1998, 280: 394-5. PMID: 9575085, DOI: 10.1126/science.280.5362.394.
- MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSINGPamer E, Cresswell P. MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING Annual Review Of Immunology 1998, 16: 323-358. PMID: 9597133, DOI: 10.1146/annurev.immunol.16.1.323.
- Induction of transporter associated with antigen processing by interferon γ confers endothelial cell cytoprotection against natural killer-mediated lysisAyalon O, Hughes E, Cresswell P, Lee J, O’Donnell L, Pardi R, Bender J. Induction of transporter associated with antigen processing by interferon γ confers endothelial cell cytoprotection against natural killer-mediated lysis Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 2435-2440. PMID: 9482903, PMCID: PMC19366, DOI: 10.1073/pnas.95.5.2435.
- Calnexin expression does not enhance the generation of MHC class I‐peptide complexesPrasad S, Yewdell J, Porgador A, Sadasivan B, Cresswell P, Bennink J. Calnexin expression does not enhance the generation of MHC class I‐peptide complexes European Journal Of Immunology 1998, 28: 907-913. PMID: 9541586, DOI: 10.1002/(sici)1521-4141(199803)28:03<907::aid-immu907>3.0.co;2-4.
- Photoactivated 8-methoxypsoralen (8-MOPa)-induced augmentation of the MHC class I antigen processing pathwayHanlon D, Cresswell P, Berger C, Edelson R. Photoactivated 8-methoxypsoralen (8-MOPa)-induced augmentation of the MHC class I antigen processing pathway Journal Of Dermatological Science 1998, 16: s158. DOI: 10.1016/s0923-1811(98)83943-1.
- Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHCHerberg J, Sgouros J, Jones T, Copeman J, Humphray S, Sheer D, Cresswell P, Beck S, Trowsdale J. Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC European Journal Of Immunology 1998, 28: 459-467. PMID: 9521053, DOI: 10.1002/(sici)1521-4141(199802)28:02<459::aid-immu459>3.0.co;2-z.
- Soluble Tapasin Restores MHC Class I Expression and Function in the Tapasin-Negative Cell Line .220Lehner P, Surman M, Cresswell P. Soluble Tapasin Restores MHC Class I Expression and Function in the Tapasin-Negative Cell Line .220 Immunity 1998, 8: 221-231. PMID: 9492003, DOI: 10.1016/s1074-7613(00)80474-4.
- Quantitative Defect in Staphylococcal Enterotoxin A Binding and Presentation by HLA-DM-Deficient T2.AkCells Corrected by Transfection of HLA-DM GenesAlbert L, Denzin L, Ghumman B, Bangia N, Cresswell P, Watts T. Quantitative Defect in Staphylococcal Enterotoxin A Binding and Presentation by HLA-DM-Deficient T2.AkCells Corrected by Transfection of HLA-DM Genes Cellular Immunology 1998, 183: 42-51. PMID: 9578718, DOI: 10.1006/cimm.1997.1236.
- Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen ProcessingDenzin L, Sant'Angelo D, Hammond C, Surman M, Cresswell P. Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing Science 1997, 278: 106-109. PMID: 9311912, DOI: 10.1126/science.278.5335.106.
- Regulation of MHC class I heterodimer stability and interaction with TAP by tapasinGrandea III A, Lehner PJ, Cresswell P, Spies T. Regulation of MHC class I heterodimer stability and interaction with TAP by tapasin Immunogenetics 1997, 46: 477-483. PMID: 9321427, DOI: 10.1007/s002510050308.
- Protein degradation: The ins and outs of the matterCresswell P, Hughes E. Protein degradation: The ins and outs of the matter Current Biology 1997, 7: r552-r555. PMID: 9285707, DOI: 10.1016/s0960-9822(06)00279-x.
- Ultraviolet B irradiation reduces the surface expression of conformationally correct class I and II histocompatibility antigensTambur A, Foster P, Mellins E, Cresswell P, Faustman D, Gebel H. Ultraviolet B irradiation reduces the surface expression of conformationally correct class I and II histocompatibility antigens Transplantation Proceedings 1997, 29: 2689-2691. PMID: 9290791, DOI: 10.1016/s0041-1345(97)00557-5.
- A Critical Role for Tapasin in the Assembly and Function of Multimeric MHC Class I-TAP ComplexesOrtmann B, Copeman J, Lehner P, Sadasivan B, Herberg J, Grandea A, Riddell S, Tampé R, Spies T, Trowsdale J, Cresswell P. A Critical Role for Tapasin in the Assembly and Function of Multimeric MHC Class I-TAP Complexes Science 1997, 277: 1306-1309. PMID: 9271576, DOI: 10.1126/science.277.5330.1306.
- The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocationLehner P, Karttunen J, Wilkinson G, Cresswell P. The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6904-6909. PMID: 9192664, PMCID: PMC21257, DOI: 10.1073/pnas.94.13.6904.
- Interferon-γ Rapidly Increases Peptide Transporter (TAP) Subunit Expression and Peptide Transport Capacity in Endothelial Cells*Ma W, Pober J, Johnson D, Lehner P, Cresswell P. Interferon-γ Rapidly Increases Peptide Transporter (TAP) Subunit Expression and Peptide Transport Capacity in Endothelial Cells* Journal Of Biological Chemistry 1997, 272: 16585-16590. PMID: 9195970, DOI: 10.1074/jbc.272.26.16585.
- Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasomeHughes E, Hammond C, Cresswell P. Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 1896-1901. PMID: 9050876, PMCID: PMC20014, DOI: 10.1073/pnas.94.5.1896.
- Antigen recognitionCresswell P, Howard J. Antigen recognition Current Opinion In Immunology 1997, 9: 71-74. PMID: 9039787, DOI: 10.1016/s0952-7915(97)80161-6.
- HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR MoleculesDenzin L, Hammond C, Cresswell P. HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR Molecules Journal Of Experimental Medicine 1996, 184: 2153-2166. PMID: 8976171, PMCID: PMC2196380, DOI: 10.1084/jem.184.6.2153.
- Trimeric Interactions of the Invariant Chain and Its Association with Major Histocompatibility Complex Class II αβ Dimers*Newcomb J, Carboy-Newcomb C, Cresswell P. Trimeric Interactions of the Invariant Chain and Its Association with Major Histocompatibility Complex Class II αβ Dimers* Journal Of Biological Chemistry 1996, 271: 24249-24256. PMID: 8798670, DOI: 10.1074/jbc.271.39.24249.
- Roles for Calreticulin and a Novel Glycoprotein, Tapasin, in the Interaction of MHC Class I Molecules with TAPSadasivan B, Lehner P, Ortmann B, Spies T, Cresswell P. Roles for Calreticulin and a Novel Glycoprotein, Tapasin, in the Interaction of MHC Class I Molecules with TAP Immunity 1996, 5: 103-114. PMID: 8769474, DOI: 10.1016/s1074-7613(00)80487-2.
- How Selective Is the TransporterAssociated with Antigen Processing?Androlewicz M, Cresswell P. How Selective Is the TransporterAssociated with Antigen Processing? Immunity 1996, 5: 1-5. PMID: 8758889, DOI: 10.1016/s1074-7613(00)80304-0.
- P513 Modulation of clip expression by ultraviolet birradiationGebel H, Mellins E, Cresswell P, Foster P, Tambur A. P513 Modulation of clip expression by ultraviolet birradiation Human Immunology 1996, 47: 94. DOI: 10.1016/0198-8859(96)85208-6.
- HLA-DM Is Localized to Conventional and Unconventional MHC Class II–Containing Endocytic CompartmentsPierre P, Denzin L, Hammond C, Drake J, Amigorena S, Cresswell P, Mellman I. HLA-DM Is Localized to Conventional and Unconventional MHC Class II–Containing Endocytic Compartments Immunity 1996, 4: 229-239. PMID: 8624813, DOI: 10.1016/s1074-7613(00)80431-8.
- Invariant Chain Structure and MHC Class II FunctionCresswell P. Invariant Chain Structure and MHC Class II Function Cell 1996, 84: 505-507. PMID: 8598037, DOI: 10.1016/s0092-8674(00)81025-9.
- Processing and delivery of peptides presented by MHC class I moleculesLehner P, Cresswell P. Processing and delivery of peptides presented by MHC class I molecules Current Opinion In Immunology 1996, 8: 59-67. PMID: 8729447, DOI: 10.1016/s0952-7915(96)80106-3.
- Class I-like CD1A-C Do Not Protect Target Cells from NK-Mediated CytolysisStorkus W, Wei M, Cresswell P, Dawson J. Class I-like CD1A-C Do Not Protect Target Cells from NK-Mediated Cytolysis Cellular Immunology 1996, 167: 154-156. PMID: 8548840, DOI: 10.1006/cimm.1996.0020.
- Trafficking of major histocompatibility complex class II molecules through intracellular compartments containing HLA-DMRobbins N, Hammond C, Denzin L, Pan M, Cresswell P. Trafficking of major histocompatibility complex class II molecules through intracellular compartments containing HLA-DM Human Immunology 1996, 45: 13-23. PMID: 8655355, DOI: 10.1016/0198-8859(95)00152-2.
- Assembly, Intracellular Localization, and Nucleotide Binding Properties of the Human Peptide Transporters TAP1 and TAP2 Expressed by Recombinant Vaccinia Viruses (∗)Russ G, Esquivel F, Yewdell J, Cresswell P, Spies T, Bennink J. Assembly, Intracellular Localization, and Nucleotide Binding Properties of the Human Peptide Transporters TAP1 and TAP2 Expressed by Recombinant Vaccinia Viruses (∗) Journal Of Biological Chemistry 1995, 270: 21312-21318. PMID: 7673167, DOI: 10.1074/jbc.270.36.21312.
- Different MHC class I alleles compete for presentation of overlapping viral epitopesTussey L, Rowland-Jones S, Zheng T, Androlewicz M, Cresswell P, Frelinger J, McMichael A. Different MHC class I alleles compete for presentation of overlapping viral epitopes Immunity 1995, 3: 65-77. PMID: 7542549, DOI: 10.1016/1074-7613(95)90159-0.
- HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loadingDenzin L, Cresswell P. HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading Cell 1995, 82: 155-165. PMID: 7606781, DOI: 10.1016/0092-8674(95)90061-6.
- Molecular Requirements for the Interaction of Class II Major Histocompatibility Complex Molecules and Invariant Chain with Calnexin (∗)Arunachalam B, Cresswell P. Molecular Requirements for the Interaction of Class II Major Histocompatibility Complex Molecules and Invariant Chain with Calnexin (∗) Journal Of Biological Chemistry 1995, 270: 2784-2790. PMID: 7852350, DOI: 10.1074/jbc.270.6.2784.
- In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptidesAvva R, Cresswell P. In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides Immunity 1994, 1: 763-774. PMID: 7895165, DOI: 10.1016/s1074-7613(94)80018-9.
- Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cellsDenzin L, Robbins N, Carboy-Newcomb C, Cresswell P. Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells Immunity 1994, 1: 595-606. PMID: 7600288, DOI: 10.1016/1074-7613(94)90049-3.
- Antigen Presentation: Getting peptides into MHC class II moleculesCresswell P. Antigen Presentation: Getting peptides into MHC class II molecules Current Biology 1994, 4: 541-543. PMID: 7922377, DOI: 10.1016/s0960-9822(00)00119-6.
- Human transporters associated with antigen processing possess a promiscuous peptide-binding siteAndrolewicz M, Cresswell P. Human transporters associated with antigen processing possess a promiscuous peptide-binding site Immunity 1994, 1: 7-14. PMID: 7889401, DOI: 10.1016/1074-7613(94)90004-3.
- Assembly, Transport, and Function of MHC Class II MoleculesCresswell P. Assembly, Transport, and Function of MHC Class II Molecules Annual Review Of Immunology 1994, 12: 259-291. PMID: 8011283, DOI: 10.1146/annurev.iy.12.040194.001355.
- MHC class l/β2-microglobulin complexes associate with TAP transporters before peptide bindingOrtmann B, Androlewicz M, Cresswell P. MHC class l/β2-microglobulin complexes associate with TAP transporters before peptide binding Nature 1994, 368: 864-867. PMID: 8159247, DOI: 10.1038/368864a0.
- Assembly and Transport of Class I MHC‐Peptide ComplexesCresswell P, Androlewicz M, Ortmann B. Assembly and Transport of Class I MHC‐Peptide Complexes 1994, 187: 150-169. PMID: 7796669, DOI: 10.1002/9780470514672.ch10.
- HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptidesRiberdy J, Newcomb J, Surman M, Barbosat J, Cresswell P. HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides Nature 1992, 360: 474-477. PMID: 1448172, DOI: 10.1038/360474a0.
- Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I moleculesArnold D, Driscoll J, Androlewicz M, Hughes E, Cresswell P, Spies T. Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules Nature 1992, 360: 171-174. PMID: 1436094, DOI: 10.1038/360171a0.
- HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptidesWei M, Cresswell P. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides Nature 1992, 356: 443-446. PMID: 1557127, DOI: 10.1038/356443a0.
- Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimerSpies T, Cerundolo V, Colonna M, Cresswell P, Townsend A, DeMars R. Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer Nature 1992, 355: 644-646. PMID: 1538752, DOI: 10.1038/355644a0.
- Chemistry and functional role of the invariant chainCresswell P. Chemistry and functional role of the invariant chain Current Opinion In Immunology 1992, 4: 87-92. PMID: 1317713, DOI: 10.1016/0952-7915(92)90131-w.
- Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chainRoche P, Marks M, Cresswell P. Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain Nature 1991, 354: 392-394. PMID: 1956401, DOI: 10.1038/354392a0.
- Isolation and characterization of a galactose-specific carbohydrate binding protein from human lymphoblastic cellsBaum L, Cresswell P. Isolation and characterization of a galactose-specific carbohydrate binding protein from human lymphoblastic cells Biochemical And Biophysical Research Communications 1990, 173: 1079-1085. PMID: 2268313, DOI: 10.1016/s0006-291x(05)80896-4.
- Transport and expression of HLA class-II glycoproteinsCresswell P, Blum J, Davis J, Marks M. Transport and expression of HLA class-II glycoproteins Immunologic Research 1990, 9: 190-199. PMID: 2121862, DOI: 10.1007/bf02918178.
- Invariant chain association with HLA-DR molecules inhibits immunogenic peptide bindingRoche P, Cresswell P. Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding Nature 1990, 345: 615-618. PMID: 2190094, DOI: 10.1038/345615a0.
- The transport of class I major histocompatibility complex antigens is determined by sequences in the α1 and α2 protein domainsAlexander J, Payne J, Shigekawa B, Frelinger J, Cresswell P. The transport of class I major histocompatibility complex antigens is determined by sequences in the α1 and α2 protein domains Immunogenetics 1990, 31: 169-178. PMID: 2318516, DOI: 10.1007/bf00211552.
- Questions of presentationCresswell P. Questions of presentation Nature 1990, 343: 593-594. PMID: 2304528, DOI: 10.1038/343593a0.
- Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartmentGuagliardi L, Koppelman B, Blum J, Marks M, Cresswell P, Brodsky F. Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment Nature 1990, 343: 133-139. PMID: 2404209, DOI: 10.1038/343133a0.
- Differential transport requirements of HLA and H-2 class I glycoproteinsAlexander J, Payne J, Murray R, Frelinger J, Cresswell P. Differential transport requirements of HLA and H-2 class I glycoproteins Immunogenetics 1989, 29: 380-388. PMID: 2731965, DOI: 10.1007/bf00375866.
- Adenovirus Inversely Modulates Target Cell Class I Antigen Expression and Sensitivity to Natural KillingStorkus W, Cresswell P, Patterson E, Dawson J. Adenovirus Inversely Modulates Target Cell Class I Antigen Expression and Sensitivity to Natural Killing 1989, 152-155. DOI: 10.1007/978-3-662-39946-0_40.
- 4 Intracellular Transport of Class II HLA AntigensCRESSWELL P, BLUM J. 4 Intracellular Transport of Class II HLA Antigens 1988, 43-51. DOI: 10.1016/b978-0-12-551855-0.50098-x.
- Localization of an epitope of beta-2 microglobulin that is shared with other members of the immunoglobulin superfamilyParham P, Lutz P, Cresswell P. Localization of an epitope of beta-2 microglobulin that is shared with other members of the immunoglobulin superfamily Immunogenetics 1987, 26: 323-326. PMID: 2443449, DOI: 10.1007/bf00346533.
- An epitope common to HLA class I and class II antigens, Ig light chains, and β2-microglobulinLutz P, Cresswell P. An epitope common to HLA class I and class II antigens, Ig light chains, and β2-microglobulin Immunogenetics 1987, 25: 228-233. PMID: 2437022, DOI: 10.1007/bf00404692.
- Intermediates in Class II HLA Antigen BiosynthesisCresswell P, Kelner D, Marks M. Intermediates in Class II HLA Antigen Biosynthesis 1987, 225: 37-42. PMID: 3331063, DOI: 10.1007/978-1-4684-5442-0_3.
- Antigen recognition by T lymphocytesCresswell P. Antigen recognition by T lymphocytes Trends In Immunology 1987, 8: 67-69. PMID: 25289464, DOI: 10.1016/0167-5699(87)90843-7.
- Immune recognition of human major histocompatibility antigens: localization by a comprehensive synthetic strategy of the continuous antigenic sites in the first domain of HLA‐DR2 β chainUlrich R, Atassi H, Lutz P, Cresswell P, Atassi M. Immune recognition of human major histocompatibility antigens: localization by a comprehensive synthetic strategy of the continuous antigenic sites in the first domain of HLA‐DR2 β chain European Journal Of Immunology 1987, 17: 497-502. PMID: 2436923, DOI: 10.1002/eji.1830170410.
- Regulation of HLA Class I and Class II antigen expressionCresswell P. Regulation of HLA Class I and Class II antigen expression British Medical Bulletin 1987, 43: 66-80. PMID: 3315102, DOI: 10.1093/oxfordjournals.bmb.a072177.
- Expression of differentiation antigens by hybrids of human lymphoblastoid cellsHowell D, Salter R, Koppelman B, Cresswell P. Expression of differentiation antigens by hybrids of human lymphoblastoid cells Human Immunology 1986, 17: 443-455. PMID: 3098709, DOI: 10.1016/0198-8859(86)90303-4.
- Evidence for methylation as a regulatory mechanism in HLA-DRx gene expressionCarrington M, Salter R, Cresswell P, Ting J. Evidence for methylation as a regulatory mechanism in HLA-DRx gene expression Immunogenetics 1985, 22: 219-229. PMID: 2995246, DOI: 10.1007/bf00404481.
- Genes regulating HLA class I antigen expression in T-B lymphoblast hybridsSalter R, Howell D, Cresswell P. Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids Immunogenetics 1985, 21: 235-246. PMID: 3872841, DOI: 10.1007/bf00375376.
- Molecular immunology, a textbook edited by M. Zouhair Atassi, Carel, J. van Oss and Darryl R. Absolom, Marcel Dekker, Inc., 1984. US$47. 50 (x + 725 pages) ISBN 0 824770455Cresswell P. Molecular immunology, a textbook edited by M. Zouhair Atassi, Carel, J. van Oss and Darryl R. Absolom, Marcel Dekker, Inc., 1984. US$47. 50 (x + 725 pages) ISBN 0 824770455 Trends In Immunology 1985, 6: 113. DOI: 10.1016/0167-5699(85)90027-1.
- Analysis of monoclonal antibodies reactive with human class II beta chains by two-dimensional electrophoresis and western blottingRadka S, Machamer C, Cresswell P. Analysis of monoclonal antibodies reactive with human class II beta chains by two-dimensional electrophoresis and western blotting Human Immunology 1984, 10: 177-188. PMID: 6611328, DOI: 10.1016/0198-8859(84)90038-7.
- Expression of class I histocompatibility antigens on human T-B lymphoblast hybridsHowell D, Kostyu D, Ting J, Cresswell P. Expression of class I histocompatibility antigens on human T-B lymphoblast hybrids Somatic Cell And Molecular Genetics 1984, 10: 217-224. PMID: 6609440, DOI: 10.1007/bf01535244.
- HLA-DR7-Specific monoclonal antibodies and a chimpanzee anti-DR7 serum detect different epitopes on the same moleculeRadka S, Bernard Amos D, Quackenbush L, Cresswell P. HLA-DR7-Specific monoclonal antibodies and a chimpanzee anti-DR7 serum detect different epitopes on the same molecule Immunogenetics 1984, 19: 63-76. PMID: 6198273, DOI: 10.1007/bf00364476.
- Expression of T-lymphoblast-encoded HLA-DR, MT, and SB antigens on human T-B lymphoblast hybridsHowell D, Hartzman R, Cresswell P. Expression of T-lymphoblast-encoded HLA-DR, MT, and SB antigens on human T-B lymphoblast hybrids Human Immunology 1983, 8: 167-175. PMID: 6417070, DOI: 10.1016/0198-8859(83)90011-3.
- Expression of T-lymphoblast-encoded HLA-DR antigens on human T-B lymphoblast hybridsHowell D, Cresswell P. Expression of T-lymphoblast-encoded HLA-DR antigens on human T-B lymphoblast hybrids Immunogenetics 1983, 17: 411-425. PMID: 6601057, DOI: 10.1007/bf00372459.
- Elimination of mycoplasma from human B-lymphoblastoid cell linesHowell D, Machamer C, Cresswell P. Elimination of mycoplasma from human B-lymphoblastoid cell lines Human Immunology 1982, 5: 233-238. PMID: 6983518, DOI: 10.1016/0198-8859(82)90136-7.
- Human T-B lymphoblast hybrids express HLA-DR specificities not expressed by either parentHowell D, Berger A, Cresswell P. Human T-B lymphoblast hybrids express HLA-DR specificities not expressed by either parent Immunogenetics 1982, 15: 199-206. PMID: 6977490, DOI: 10.1007/bf00621951.
- Expression of cell surface lectins on activated human lymphoid cellsApgar J, Cresswell P. Expression of cell surface lectins on activated human lymphoid cells European Journal Of Immunology 1982, 12: 570-576. PMID: 6214410, DOI: 10.1002/eji.1830120708.
- Monoclonal Antibody to HLA-A3BERGER A, DAVIS J, CRESSWELL P. Monoclonal Antibody to HLA-A3 Monoclonal Antibodies In Immunodiagnosis And Immunotherapy 1982, 1: 87-90. PMID: 6208124, DOI: 10.1089/hyb.1.1982.1.87.
- A human leukocyte antigen identified by a monoclonal antibodyBerger A, Davis J, Cresswell P. A human leukocyte antigen identified by a monoclonal antibody Human Immunology 1981, 3: 231-245. PMID: 6975769, DOI: 10.1016/0198-8859(81)90020-3.
- HLA control of interferon production in the human mixed lymphocyte cultureAndreotti P, Cresswell P. HLA control of interferon production in the human mixed lymphocyte culture Human Immunology 1981, 3: 109-120. PMID: 6173359, DOI: 10.1016/0198-8859(81)90048-3.
- Serological and Cellular Recognition of Human Histocompatibility AntigensCresswell P, Andreotti P, Apgar J, Louise Markert M. Serological and Cellular Recognition of Human Histocompatibility Antigens 1981, 15-27. DOI: 10.1007/978-1-4684-3758-4_2.
- A public HLA antigen associated with HLA-A9, Aw32, and Bw4Kostyu D, Cresswell P, Amos D. A public HLA antigen associated with HLA-A9, Aw32, and Bw4 Immunogenetics 1980, 10: 433-442. PMID: 22457917, DOI: 10.1007/bf01572579.
- HLA-A2 as a target for cell-mediated lympholysis: Evidence from immunoselected HLA-A2 negative mutant cell linesAndreotti P, Apgar J, Cresswell P. HLA-A2 as a target for cell-mediated lympholysis: Evidence from immunoselected HLA-A2 negative mutant cell lines Human Immunology 1980, 1: 77-86. PMID: 7263311, DOI: 10.1016/0198-8859(80)90011-7.
- Monocytes as accessory cells in the human mixed lymphocyte response: Lack of requirement at high cell densitiesGeier S, Cresswell P. Monocytes as accessory cells in the human mixed lymphocyte response: Lack of requirement at high cell densities Cellular Immunology 1980, 49: 190-195. PMID: 6444277, DOI: 10.1016/0008-8749(80)90068-4.
- Transferrin receptors on human B and T lymphosblastoid cell linesLarrick J, Cresswell P. Transferrin receptors on human B and T lymphosblastoid cell lines Biochimica Et Biophysica Acta 1979, 583: 483-490. PMID: 218639, DOI: 10.1016/0304-4165(79)90065-5.
- Modulation of cell surface iron transferrin receptors by cellular density and state of activationLarrick J, Cresswell P. Modulation of cell surface iron transferrin receptors by cellular density and state of activation Journal Of Cellular Biochemistry 1979, 11: 579-586. PMID: 232525, DOI: 10.1002/jss.400110415.
- Rabbit antiserum to human B-cell alloantigens II. Mechanism of inhibition of stimulation in the mixed lymphocyte responseGeier S, Cresswell P. Rabbit antiserum to human B-cell alloantigens II. Mechanism of inhibition of stimulation in the mixed lymphocyte response Cellular Immunology 1978, 35: 392-402. PMID: 145900, DOI: 10.1016/0008-8749(78)90158-2.
- Human B cell alloantigens: separation from other membrane molecules by affinity chromatographyCresswell P. Human B cell alloantigens: separation from other membrane molecules by affinity chromatography European Journal Of Immunology 1977, 7: 636-639. PMID: 303569, DOI: 10.1002/eji.1830070911.
- Robbit antisera to human B cell alloantigens: Effects on the mixed lymphocyte responseGeier S, Cresswell P. Robbit antisera to human B cell alloantigens: Effects on the mixed lymphocyte response Cellular Immunology 1977, 28: 341-354. PMID: 139207, DOI: 10.1016/0008-8749(77)90117-4.
- HLA‐B specificities and w4, w6 specificities are on the same polypeptideAyres J, Cresswell P. HLA‐B specificities and w4, w6 specificities are on the same polypeptide European Journal Of Immunology 1976, 6: 794-799. PMID: 63373, DOI: 10.1002/eji.1830061108.
- HLA antigens: rabbit antisera reacting with all A series or all B series specificitiesCresswell P, Ayres J. HLA antigens: rabbit antisera reacting with all A series or all B series specificities European Journal Of Immunology 1976, 6: 82-88. PMID: 786698, DOI: 10.1002/eji.1830060203.
- The role of serum in the in vitro assay of lymphocyte-mediated cytolysisVadnais P, Cresswell P, Amos D. The role of serum in the in vitro assay of lymphocyte-mediated cytolysis Cellular Immunology 1976, 21: 350-357. PMID: 1260866, DOI: 10.1016/0008-8749(76)90063-0.
- Antisera to human B-lymphocyte membrane glycoproteins block stimulation in mixed lymphocyte cultureCRESSWELL P, GEIER S. Antisera to human B-lymphocyte membrane glycoproteins block stimulation in mixed lymphocyte culture Nature 1975, 257: 147-149. PMID: 51476, DOI: 10.1038/257147a0.
- Purification of papain-solubilized histocompatibility antigens from a cultured human lymphoblastoid line, RPMI 4265.Turner M, Cresswell P, Parham P, Strominger J, Mann D, Sanderson A. Purification of papain-solubilized histocompatibility antigens from a cultured human lymphoblastoid line, RPMI 4265. Journal Of Biological Chemistry 1975, 250: 4512-4519. PMID: 1141219, DOI: 10.1016/s0021-9258(19)41332-x.
- The Immunoglobulin‐Like Structure of Human Histocompatibility AntigensStrominger J, Cresswell P, Grey H, Humphreys R, Mann D, Mccune J, Parham P, Robb R, Sanderson A, Springer T, Terhorst C, Turner M. The Immunoglobulin‐Like Structure of Human Histocompatibility Antigens Immunological Reviews 1974, 21: 126-143. PMID: 4139785, DOI: 10.1111/j.1600-065x.1974.tb01549.x.
- Immunological Identity of the Small Subunit of HL-A Antigens and β2-Microglobulin and Its Turnover on the Cell MembraneCresswell P, Springer T, Strominger J, Turner M, Grey H, Kubo R. Immunological Identity of the Small Subunit of HL-A Antigens and β2-Microglobulin and Its Turnover on the Cell Membrane Proceedings Of The National Academy Of Sciences Of The United States Of America 1974, 71: 2123-2127. PMID: 4134761, PMCID: PMC388399, DOI: 10.1073/pnas.71.5.2123.
- Papain-solubilized HL-A Antigens CHROMATOGRAPHIC AND ELECTROPHORETIC STUDIES OF THE TWO SUBUNITS FROM DIFFERENT SPECIFICITIESCresswell P, Robb R, Turner M, Strominger J. Papain-solubilized HL-A Antigens CHROMATOGRAPHIC AND ELECTROPHORETIC STUDIES OF THE TWO SUBUNITS FROM DIFFERENT SPECIFICITIES Journal Of Biological Chemistry 1974, 249: 2828-2832. PMID: 4828322, DOI: 10.1016/s0021-9258(19)42705-1.
- THE SMALL SUBUNIT OF HL-A ANTIGENS IS ß2-MICROGLOBULINGrey H, Kubo R, Colon S, Poulik M, Cresswell P, Springer T, Turner M, Strominger J. THE SMALL SUBUNIT OF HL-A ANTIGENS IS ß2-MICROGLOBULIN Journal Of Experimental Medicine 1973, 138: 1608-1612. PMID: 4128442, PMCID: PMC2139471, DOI: 10.1084/jem.138.6.1608.
- Papain-Solubilized HL-A Antigens from Cultured Human Lymphocytes Contain Two Peptide FragmentsCresswell P, Turner M, Strominger J. Papain-Solubilized HL-A Antigens from Cultured Human Lymphocytes Contain Two Peptide Fragments Proceedings Of The National Academy Of Sciences Of The United States Of America 1973, 70: 1603-1607. PMID: 4514327, PMCID: PMC433551, DOI: 10.1073/pnas.70.5.1603.
- THE CYTOTOXIC EFFECT ON HUMAN LYMPHOCYTES OF RABBIT ANTISERA TO HUMAN FC (IGG)WELSH K, CRESSWELL P, GOUJET C, SANDERSON A. THE CYTOTOXIC EFFECT ON HUMAN LYMPHOCYTES OF RABBIT ANTISERA TO HUMAN FC (IGG) Transplantation 1971, 12: 468-471. PMID: 5165966, DOI: 10.1097/00007890-197112000-00009.
- Involvement of Carbohydrate in the Immunochemical Determinant Area of HL-A SubstancesSANDERSON A, CRESSWELL P, WELSH K. Involvement of Carbohydrate in the Immunochemical Determinant Area of HL-A Substances Nature 1971, 230: 8-12. PMID: 4104302, DOI: 10.1038/newbio230008a0.
- Preparation, properties and substrate-exclusion effects of an insoluble pronase derivativeCresswell P, Sanderson A. Preparation, properties and substrate-exclusion effects of an insoluble pronase derivative Biochemical Journal 1970, 119: 447-451. PMID: 5500304, PMCID: PMC1179373, DOI: 10.1042/bj1190447.
- SPATIAL ARRANGEMENT OF H-2 SPECIFICITIES: EVIDENCE FROM ANTIBODY ADSORPTION AND KINETIC STUDIESCresswell P, Sanderson A. SPATIAL ARRANGEMENT OF H-2 SPECIFICITIES: EVIDENCE FROM ANTIBODY ADSORPTION AND KINETIC STUDIES Transplantation 1968, 6: 996-1004. PMID: 5722180, DOI: 10.1097/00007890-196812000-00006.