Pallavi Gopal, MD, PhD
Assistant Professor of Pathology
Research & Publications
Biography
News
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Research Summary
The Gopal lab is broadly interested in mRNA transport, RNA metabolism and its regulation in healthy and diseased neurons. As a physician-scientist, Dr. Gopal’s research aims to bridge neuronal cell biology and neuropathology of neurodegenerative disease. Her post-doctoral research provided new insight into the biophysical properties of neuronal ribonucleoprotein (RNP) granules and has shown that ALS-linked mutations fundamentally perturb the dynamic properties and transport of neuronal RNP complexes. The focus of the Gopal lab is to elucidate the molecular mechanisms driving neuronal RNP granule assembly, the spatiotemporal maturation and function of diverse RNP granules in neuronal physiology, and pathologic transitions in disease.
Coauthors
Research Interests
Amyotrophic Lateral Sclerosis; Autopsy; Cell Biology; Neurons; Ribonucleoproteins; Neurodegenerative Diseases; RNA Transport; Frontotemporal Lobar Degeneration; TDP-43 Proteinopathies
Selected Publications
- Epstein-Barr virus–associated primary intracranial leiomyosarcoma in an immunocompetent patient: illustrative caseTabor J, Lei H, Morales-Valero S, O’Brien J, Gopal P, Erson-Omay E, Fulbright R, Moliterno J. Epstein-Barr virus–associated primary intracranial leiomyosarcoma in an immunocompetent patient: illustrative case. Journal Of Neurosurgery Case Lessons 2023, 5: case22532. PMID: 36692065, PMCID: PMC10550697, DOI: 10.3171/case22532.
- Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors—A prospective study and guidelines for clinical testingGalbraith K, Vasudevaraja V, Serrano J, Shen G, Tran I, Abdallat N, Wen M, Patel S, Movahed-Ezazi M, Faustin A, Spino-Keeton M, Roberts L, Maloku E, Drexler S, Liechty B, Pisapia D, Krasnozhen-Ratush O, Rosenblum M, Shroff S, Boué D, Davidson C, Mao Q, Suchi M, North P, Hopp A, Segura A, Jarzembowski J, Parsons L, Johnson M, Mobley B, Samore W, McGuone D, Gopal P, Canoll P, Horbinski C, Fullmer J, Farooqi M, Gokden M, Wadhwani N, Richardson T, Umphlett M, Tsankova N, DeWitt J, Sen C, Placantonakis D, Pacione D, Wisoff J, Hidalgo E, Harter D, William C, Cordova C, Kurz S, Barbaro M, Orringer D, Karajannis M, Sulman E, Gardner S, Zagzag D, Tsirigos A, Allen J, Golfinos J, Snuderl M. Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors—A prospective study and guidelines for clinical testing. Neuro-Oncology Advances 2023, 5: vdad076. PMID: 37476329, PMCID: PMC10355794, DOI: 10.1093/noajnl/vdad076.
- Sequence Determinants of TDP-43 Ribonucleoprotein Condensate Formation and Axonal Transport in NeuronsVishal SS, Wijegunawardana D, Salaikumaran MR, Gopal PP. Sequence Determinants of TDP-43 Ribonucleoprotein Condensate Formation and Axonal Transport in Neurons. Frontiers In Cell And Developmental Biology 2022, 10: 876893. PMID: 35646935, PMCID: PMC9133736, DOI: 10.3389/fcell.2022.876893.
- Comprehensive Genomic Characterization of A Case of Granular Cell Tumor of the Posterior Pituitary Gland: A Case ReportHong CS, Elsamadicy AA, Fisayo A, Inzucchi SE, Gopal PP, Vining EM, Erson-Omay EZ, Omay S. Comprehensive Genomic Characterization of A Case of Granular Cell Tumor of the Posterior Pituitary Gland: A Case Report. Frontiers In Endocrinology 2021, 12: 762095. PMID: 34925233, PMCID: PMC8671743, DOI: 10.3389/fendo.2021.762095.
- Genetic characterization of an aggressive optic nerve pilocytic gliomaHong CS, Fliney G, Fisayo A, An Y, Gopal PP, Omuro A, Pointdujour-Lim R, Erson-Omay EZ, Omay SB. Genetic characterization of an aggressive optic nerve pilocytic glioma. Brain Tumor Pathology 2020, 38: 59-63. PMID: 33098465, PMCID: PMC7585354, DOI: 10.1007/s10014-020-00383-x.
- RNA-binding proteins in neurological development and diseasePrashad S, Gopal PP. RNA-binding proteins in neurological development and disease. RNA Biology 2020, 18: 972-987. PMID: 32865115, PMCID: PMC8216196, DOI: 10.1080/15476286.2020.1809186.
- Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neuronsStavoe A, Gopal P, Gubas A, Tooze S, Holzbaur E. Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons. ELife 2019, 8: e44219. PMID: 31309927, PMCID: PMC6634969, DOI: 10.7554/elife.44219.
- Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neuronsGopal PP, Nirschl JJ, Klinman E, Holzbaur EL. Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e2466-e2475. PMID: 28265061, PMCID: PMC5373408, DOI: 10.1073/pnas.1614462114.
- MicroRNA-124 expression counteracts pro-survival stress responses in glioblastomaMucaj V, Lee S, Skuli N, Giannoukos D, Qiu B, Eisinger-Mathason T, Nakazawa M, Shay J, Gopal P, Venneti S, Lal P, Minn A, Simon M, Mathew L. MicroRNA-124 expression counteracts pro-survival stress responses in glioblastoma. Oncogene 2014, 34: 2204-2214. PMID: 24954504, PMCID: PMC4275412, DOI: 10.1038/onc.2014.168.
- Advanced neuroimaging findings of pseudotumoral hemicerebellitis in an elderly male requiring surgical decompression.Gupta R, Maralani P, Chawla S, Gopal P, Mohan S. Advanced neuroimaging findings of pseudotumoral hemicerebellitis in an elderly male requiring surgical decompression. Journal Of Neurosurgery 2013, 120: 522-7. PMID: 24329022, DOI: 10.3171/2013.11.jns13980.
- Pax6-/- mice have a cell non-autonomous defect in non-radial interneuron migrationGopal P, Golden J. Pax6-/- mice have a cell non-autonomous defect in non-radial interneuron migration. Journal Of Neuropathology & Experimental Neurology 2007, 66: 436. DOI: 10.1097/01.jnen.0000268879.60312.80.
- Pax6−/− Mice have a Cell Non‐Autonomous Defect in Non‐Radial Interneuron MigrationGopal P, Golden J. Pax6−/− Mice have a Cell Non‐Autonomous Defect in Non‐Radial Interneuron Migration. The FASEB Journal 2007, 21: a75-a75. DOI: 10.1096/fasebj.21.5.a75-a.
- Suppression of laminin-5 expression leads to increased motility, tumorigenicity, and invasionYuen H, Ziober A, Gopal P, Nasrallah I, Falls E, Meneguzzi G, Ang H, Ziober B. Suppression of laminin-5 expression leads to increased motility, tumorigenicity, and invasion. Experimental Cell Research 2005, 309: 198-210. PMID: 15963983, DOI: 10.1016/j.yexcr.2005.05.013.
- Axon Mediated Interneuron MigrationMcManus M, Nasrallah I, Gopal P, Baek W, Golden J. Axon Mediated Interneuron Migration. Journal Of Neuropathology & Experimental Neurology 2004, 63: 932-941. PMID: 15453092, DOI: 10.1093/jnen/63.9.932.