Lauren Cohn, MD

• Clemente Britto-Leon
• Geoffrey Chupp
• Lokesh Kumar Sharma
• Naftali Kaminski
• Robert Homer
• Xiting Yan

Asthma; Epithelium; Lung; Lung Diseases; Metaplasia; Airway Management

• INCREASED CYTOKINE LEVELS DEFINE THE AIRWAY OF STABLE CYSTIC FIBROSIS PATIENTS COMPARED TO HEALTHY CONTROLSZielonka J, Khanal S, liu Q, Cohn L, Chupp G, Britto C. INCREASED CYTOKINE LEVELS DEFINE THE AIRWAY OF STABLE CYSTIC FIBROSIS PATIENTS COMPARED TO HEALTHY CONTROLS CHEST Journal 2021, 160: a1450-a1451. DOI: 10.1016/j.chest.2021.07.1327.
• Characterization of Sputum Single Cell Transcriptomes in AsthmaYan X, Liu Q, Adams T, Schupp J, Grant N, Gomez J, Cohn L, Chupp G. Characterization of Sputum Single Cell Transcriptomes in Asthma 2020, a3046-a3046. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3046.
• BPI-fold containing Family A member 1 (Bpifa1) Role in IFN Driven Pulmonary ResponseKhanal S, Niu N, Sharma L, Liu W, Cohn L, Dela Cruz C, Britto C. BPI-fold containing Family A member 1 (Bpifa1) Role in IFN Driven Pulmonary Response 2019, pa2385. DOI: 10.1183/13993003.congress-2019.pa2385.
• Human Lung MicroRNA-1 Is Regulated by IL-13 and Correlates with Tissue Eosinophilia in Airway InflammationHu B, Korde A, Cohn L, Chu J, Takyar S. Human Lung MicroRNA-1 Is Regulated by IL-13 and Correlates with Tissue Eosinophilia in Airway Inflammation 2019, a2931-a2931. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2931.
• BPIFA1 Regulates Neutrophilic Response of Influenza A Virus InfectionKhanal S, Niu N, Sharma L, Bermejo S, Liu W, Delacruz C, Cohn L, Britto-Leon C. BPIFA1 Regulates Neutrophilic Response of Influenza A Virus Infection 2019, a5745-a5745. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5745.
• MicroRNA miR-223 Is Associated with Lung Function Impairment and TH17 Inflammation in AsthmaGomez J, Chen A, Yan X, Cohn L, Chupp G. MicroRNA miR-223 Is Associated with Lung Function Impairment and TH17 Inflammation in Asthma 2019, a2929-a2929. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2929.
• Cell Lineage Defined by Single Cell Transcriptomics of the Sputum in AsthmaYan X, Liu Q, Mihaljinec A, Gomez J, Cohn L, Chupp G. Cell Lineage Defined by Single Cell Transcriptomics of the Sputum in Asthma 2019, a6085-a6085. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6085.
• BPI Fold-Containing Family A Member 1 (BPIFA1) regulates lung neutrophil recruitment and interferon signaling during acute inflammationKhanal S, Niu N, Huleihel L, Herazo-Maya J, Kaminski N, Cohn L, Britto C. BPI Fold-Containing Family A Member 1 (BPIFA1) regulates lung neutrophil recruitment and interferon signaling during acute inflammation 2018, pa4254. DOI: 10.1183/13993003.congress-2018.pa4254.
• MAPKAP kinase 2(MK2) expression is associated with severe asthmaChupp G, Yan X, Nezgovorova V, Grant N, Bradford W, Brophy C, Cohn L. MAPKAP kinase 2(MK2) expression is associated with severe asthma 2016, pa4649. DOI: 10.1183/13993003.congress-2016.pa4649.
• Proinflammatory cytokines and IP-10 differentiate neutrophilic and eosinophilic asthma subgroupsGueble M, Holm C, Grant N, Ravage-Mass L, Levesh T, Estrom J, Kapagiannidou E, Liu Q, O'Connor P, Gomez-Villalobos J, Cohn L, Chupp G. Proinflammatory cytokines and IP-10 differentiate neutrophilic and eosinophilic asthma subgroups 2016, pa908. DOI: 10.1183/13993003.congress-2016.pa908.
• VEGF controls lung Th2 inflammation via the miR-1–Mpl (myeloproliferative leukemia virus oncogene)–P-selectin axisTakyar S, Vasavada H, Zhang J, Ahangari F, Niu N, Liu Q, Lee C, Cohn L, Elias J. VEGF controls lung Th2 inflammation via the miR-1–Mpl (myeloproliferative leukemia virus oncogene)–P-selectin axis Journal Of Cell Biology 2013, 202: 2027oia101. DOI: 10.1083/jcb.2027oia101.
• SPLUNC1 Is Inhibited In Common Respiratory Infections By Toll-Like Receptor (TLR) Activation And Inflammatory CytokinesBritto C, Liu Q, Dela Cruz C, Cohn L. SPLUNC1 Is Inhibited In Common Respiratory Infections By Toll-Like Receptor (TLR) Activation And Inflammatory Cytokines 2012, a1065-a1065. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1065.
• Characterization Of The Poor Emotional Function Phenotype In AsthmaScatena R, Holm C, He S, Wright P, Sessa W, Cohn L, Gomez-Villalobos J, Mitchell A, Chupp G. Characterization Of The Poor Emotional Function Phenotype In Asthma 2012, a3967-a3967. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3967.
• IFN-γ Acts on the Airway Epithelium To Inhibit Local and Systemic Pathology in Allergic Airway DiseaseMitchell C, Provost K, Niu N, Homer R, Cohn L. IFN-γ Acts on the Airway Epithelium To Inhibit Local and Systemic Pathology in Allergic Airway Disease The Journal Of Immunology 2011, 187: 3815-3820. PMID: 21873527, PMCID: PMC3178669, DOI: 10.4049/jimmunol.1100436.
• IFN-? Inhibits Goblet Cell DifferentiationNiu N, Provost K, Homer R, Cohn L. IFN-? Inhibits Goblet Cell Differentiation 2011, a2052-a2052. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2052.
• Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammationWright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC. Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation Journal Of Experimental Medicine 2010, 207: 2595-2607. PMID: 20975041, PMCID: PMC2989775, DOI: 10.1084/jem.20100786.
• IFN-³ Acts On The Airway Epithelium To Regulate Allergic Airway InflammationCohn L, Provost K, Homer R, Niu N, Andreasen C. IFN-³ Acts On The Airway Epithelium To Regulate Allergic Airway Inflammation 2010, a2485-a2485. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2485.
• Interferon Gamma Inhibits Th2 Induced Mucus Metaplasia In Vivo Through Effects On Epithelial IL-4 And IL-13 Receptor Expression, And Inhibition Of Stat6 PhosphorylationProvost K, Niu N, Homer R, Cohn L. Interferon Gamma Inhibits Th2 Induced Mucus Metaplasia In Vivo Through Effects On Epithelial IL-4 And IL-13 Receptor Expression, And Inhibition Of Stat6 Phosphorylation 2010, a4038-a4038. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4038.
• PLUNC Is An Immunoregulatory Protein That Controls Eosinophilia In Allergic Airway InflammationLiu Q, Curran D, Britto C, Patham B, Cohn L. PLUNC Is An Immunoregulatory Protein That Controls Eosinophilia In Allergic Airway Inflammation 2010, a5595-a5595. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5595.
• Microbial And Inflammatory Signals Promote Airway Inflammation By Inhibiting The Epithelial Protein PLUNCBritto C, Curran D, Liu Q, Cohn L. Microbial And Inflammatory Signals Promote Airway Inflammation By Inhibiting The Epithelial Protein PLUNC 2010, a1389-a1389. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1389.
• Cutting Edge: Limiting MHC Class II Expression to Dendritic Cells Alters the Ability to Develop Th2- Dependent Allergic Airway InflammationNiu N, Laufer T, Homer RJ, Cohn L. Cutting Edge: Limiting MHC Class II Expression to Dendritic Cells Alters the Ability to Develop Th2- Dependent Allergic Airway Inflammation The Journal Of Immunology 2009, 183: 1523-1527. PMID: 19596982, DOI: 10.4049/jimmunol.0901349.
• Advances in Mucous Cell MetaplasiaCurran DR, Cohn L. Advances in Mucous Cell Metaplasia American Journal Of Respiratory Cell And Molecular Biology 2009, 42: 268-275. PMID: 19520914, PMCID: PMC2830403, DOI: 10.1165/rcmb.2009-0151tr.
• A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthmaCaceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 9099-9104. PMID: 19458046, PMCID: PMC2684498, DOI: 10.1073/pnas.0900591106.
• Decreased Ovalbumin‐induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1Caceres A, Brackmann M, Bessac B, Cohn L, Jordt S. Decreased Ovalbumin‐induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1 The FASEB Journal 2009, 23: 580.10-580.10. DOI: 10.1096/fasebj.23.1_supplement.580.10.
• Decreased Ovalbumin-Induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1.Caceres A, Brackmann M, Bessac B, Sui A, Cohn L, Jordt. Decreased Ovalbumin-Induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1. 2009, a6324. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a6324.
• Response to Comment on “A Novel Pathway That Regulates Inflammatory Disease in the Respiratory Tract”Niu N, Cohn L. Response to Comment on “A Novel Pathway That Regulates Inflammatory Disease in the Respiratory Tract” The Journal Of Immunology 2007, 178: 7501-7502. DOI: 10.4049/jimmunol.178.12.7501-a.
• A Novel Pathway That Regulates Inflammatory Disease in the Respiratory TractNiu N, Le Goff MK, Li F, Rahman M, Homer RJ, Cohn L. A Novel Pathway That Regulates Inflammatory Disease in the Respiratory Tract The Journal Of Immunology 2007, 178: 3846-3855. PMID: 17339484, DOI: 10.4049/jimmunol.178.6.3846.
• Asthma: Mechanisms of Disease Persistence and ProgressionCohn L, Elias JA, Chupp GL. Asthma: Mechanisms of Disease Persistence and Progression Annual Review Of Immunology 2004, 22: 789-815. PMID: 15032597, DOI: 10.1146/annurev.immunol.22.012703.104716.
• Recent Concepts in the Pathogenesis and Treatment of AsthmaWhittaker L, Cohn L. Recent Concepts in the Pathogenesis and Treatment of Asthma Clinical Pulmonary Medicine 2002, 9: 135-144. DOI: 10.1097/00045413-200205000-00001.
• IL-4 Promotes Airway Eosinophilia by Suppressing IFN-γ Production: Defining a Novel Role for IFN-γ in the Regulation of Allergic Airway InflammationCohn L, Herrick C, Niu N, Homer R, Bottomly K. IL-4 Promotes Airway Eosinophilia by Suppressing IFN-γ Production: Defining a Novel Role for IFN-γ in the Regulation of Allergic Airway Inflammation The Journal Of Immunology 2001, 166: 2760-2767. PMID: 11160342, DOI: 10.4049/jimmunol.166.4.2760.
• A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammationDas J, Chen C, Yang L, Cohn L, Ray P, Ray A. A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation Nature Immunology 2001, 2: 45-50. PMID: 11135577, DOI: 10.1038/83158.
• T-helper type 2 cell-directed therapy for asthmaCohn L, Ray A. T-helper type 2 cell-directed therapy for asthma Pharmacology & Therapeutics 2000, 88: 187-196. PMID: 11150597, DOI: 10.1016/s0163-7258(00)00091-7.
• IL-11 Selectively Inhibits Aeroallergen-Induced Pulmonary Eosinophilia and Th2 Cytokine ProductionWang J, Homer R, Hong L, Cohn L, Lee C, Jung S, Elias J. IL-11 Selectively Inhibits Aeroallergen-Induced Pulmonary Eosinophilia and Th2 Cytokine Production The Journal Of Immunology 2000, 165: 2222-2231. PMID: 10925310, DOI: 10.4049/jimmunol.165.4.2222.
• T Helper 1 Cells and Interferon γ Regulate Allergic Airway Inflammation and Mucus ProductionCohn L, Homer R, Niu N, Bottomly K. T Helper 1 Cells and Interferon γ Regulate Allergic Airway Inflammation and Mucus Production Journal Of Experimental Medicine 1999, 190: 1309-1318. PMID: 10544202, PMCID: PMC2195688, DOI: 10.1084/jem.190.9.1309.
• Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3Zhang D, Yang L, Cohn L, Parkyn L, Homer R, Ray P, Ray A. Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3 Immunity 1999, 11: 473-482. PMID: 10549629, DOI: 10.1016/s1074-7613(00)80122-3.
• Essential Role of Nuclear Factor κB in the Induction of Eosinophilia in Allergic Airway InflammationYang L, Cohn L, Zhang D, Homer R, Ray A, Ray P. Essential Role of Nuclear Factor κB in the Induction of Eosinophilia in Allergic Airway Inflammation Journal Of Experimental Medicine 1998, 188: 1739-1750. PMID: 9802985, PMCID: PMC2212522, DOI: 10.1084/jem.188.9.1739.
• Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus ProductionCohn L, Homer R, Marinov A, Rankin J, Bottomly K. Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production Journal Of Experimental Medicine 1997, 186: 1737-1747. PMID: 9362533, PMCID: PMC2199146, DOI: 10.1084/jem.186.10.1737.
• Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene*Zhang D, Cohn L, Ray P, Bottomly K, Ray A. Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene* Journal Of Biological Chemistry 1997, 272: 21597-21603. PMID: 9261181, DOI: 10.1074/jbc.272.34.21597.