Lauren Cohn, MD
Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine); Director, Newington VA Pulmonary Clinic, Medicine; Co-Director, Yale Center for Asthma and Airway Diseases
Research & Publications
Biography
News
Locations
Research Summary
Dr. Cohn's research focuses on airway inflammation. Ongoing projects in the laboratory include (1) defining inflammatory pathways that inhibit allergic airway inflammation and asthma, (2) investigations of the airway epithelium in its contribution to lung inflammation, (3) immunologic pathways that provide protection in inflammatory diseases and mycobacterial infection.
Specialized Terms: Chronic inflammation in asthma; Mechanisms of mucus metaplasia; Airway epithelial functions in airway diseases and host defense
Coauthors
Research Interests
Asthma; Epithelium; Lung; Lung Diseases; Metaplasia; Airway Management
Selected Publications
- IFN-γ Acts on the Airway Epithelium To Inhibit Local and Systemic Pathology in Allergic Airway DiseaseMitchell C, Provost K, Niu N, Homer R, Cohn L. IFN-γ Acts on the Airway Epithelium To Inhibit Local and Systemic Pathology in Allergic Airway Disease The Journal Of Immunology 2011, 187: 3815-3820. PMID: 21873527, PMCID: PMC3178669, DOI: 10.4049/jimmunol.1100436.
- Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammationWright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC. Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation Journal Of Experimental Medicine 2010, 207: 2595-2607. PMID: 20975041, PMCID: PMC2989775, DOI: 10.1084/jem.20100786.
- Cutting Edge: Limiting MHC Class II Expression to Dendritic Cells Alters the Ability to Develop Th2- Dependent Allergic Airway InflammationNiu N, Laufer T, Homer RJ, Cohn L. Cutting Edge: Limiting MHC Class II Expression to Dendritic Cells Alters the Ability to Develop Th2- Dependent Allergic Airway Inflammation The Journal Of Immunology 2009, 183: 1523-1527. PMID: 19596982, DOI: 10.4049/jimmunol.0901349.
- Advances in Mucous Cell MetaplasiaCurran DR, Cohn L. Advances in Mucous Cell Metaplasia American Journal Of Respiratory Cell And Molecular Biology 2009, 42: 268-275. PMID: 19520914, PMCID: PMC2830403, DOI: 10.1165/rcmb.2009-0151tr.
- A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthmaCaceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 9099-9104. PMID: 19458046, PMCID: PMC2684498, DOI: 10.1073/pnas.0900591106.
- A Novel Pathway That Regulates Inflammatory Disease in the Respiratory TractNiu N, Le Goff MK, Li F, Rahman M, Homer RJ, Cohn L. A Novel Pathway That Regulates Inflammatory Disease in the Respiratory Tract The Journal Of Immunology 2007, 178: 3846-3855. PMID: 17339484, DOI: 10.4049/jimmunol.178.6.3846.
- Asthma: Mechanisms of Disease Persistence and ProgressionCohn L, Elias JA, Chupp GL. Asthma: Mechanisms of Disease Persistence and Progression Annual Review Of Immunology 2004, 22: 789-815. PMID: 15032597, DOI: 10.1146/annurev.immunol.22.012703.104716.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Asthma; Diseases of the Lung | Tezepelumab COPD Exacerbation Study (COURSE) |
| Asthma; Men's Health; Women's Health | Observational Study of Characteristics, Treatment and Outcomes With Severe Asthma in the United States (CHRONICLE) |