Ke Xu, MD
Professor of Psychiatry; Director of Stress Epigenetics, Yale Stress Center
Research & Publications
Biography
News
Research Summary
Our research goals are to better understand genetic and environmental risks on substance abuse and other psychiatric disorders and translate genetic findings to clinic use.
Coauthors
Research Interests
Mental Disorders; Genetics, Behavioral
Public Health Interests
Genetics, Genomics, Epigenetics; Mental Health; Substance Use, Addiction
Selected Publications
- Childhood adversity, accelerated GrimAge, and associated health consequencesHarvanek Z, Kudinova A, Wong S, Xu K, Brick L, Daniels T, Marsit C, Burt A, Sinha R, Tyrka A. Childhood adversity, accelerated GrimAge, and associated health consequences. Journal Of Behavioral Medicine 2024, 1-14. PMID: 38762606, DOI: 10.1007/s10865-024-00496-0.
- Author Correction: A multi-ancestry genetic study of pain intensity in 598,339 veteransToikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell E, Pavicic M, Sullivan K, Xu K, Jacobson D, Gelernter J, Rentsch C, Stahl E, Cheatle M, Zhou H, Waxman S, Justice A, Kember R, Kranzler H. Author Correction: A multi-ancestry genetic study of pain intensity in 598,339 veterans. Nature Medicine 2024, 1-1. PMID: 38714900, DOI: 10.1038/s41591-024-03024-4.
- Greater Stress and Trauma Mediate Race-Related Differences in Epigenetic Age Between Black and White Young Adults in a Community SampleHolloway T, Harvanek Z, Xu K, Gordon D, Sinha R. Greater Stress and Trauma Mediate Race-Related Differences in Epigenetic Age Between Black and White Young Adults in a Community Sample. Biological Psychiatry 2024, 95: s41. DOI: 10.1016/j.biopsych.2024.02.104.
- 353. Methylation of CRHR1 and CRHR2 is Associated With Lifetime Adversity, HPA-Axis Signaling Changes, and ObesityHarvanek Z, Zhang X, Xu K, Sinha R. 353. Methylation of CRHR1 and CRHR2 is Associated With Lifetime Adversity, HPA-Axis Signaling Changes, and Obesity. Biological Psychiatry 2024, 95: s244. DOI: 10.1016/j.biopsych.2024.02.852.
- Study on Raman scattering spectroscopy of Mn-doped GaN grown by the ammonothermal methodLu W, Li T, Ren G, Xia Z, Xie K, Li S, Shen L, Xu K. Study on Raman scattering spectroscopy of Mn-doped GaN grown by the ammonothermal method. CrystEngComm 2024, 26: 2166-2171. DOI: 10.1039/d4ce00093e.
- DNA methylation‐based telomere length is associated with HIV infection, physical frailty, cancer, and all‐cause mortalityLiang X, Aouizerat B, So‐Armah K, Cohen M, Marconi V, Xu K, Justice A. DNA methylation‐based telomere length is associated with HIV infection, physical frailty, cancer, and all‐cause mortality. Aging Cell 2024, e14174. PMID: 38629454, DOI: 10.1111/acel.14174.
- Computationally inferred cell-type specific epigenome-wide DNA methylation analysis unveils distinct methylation patterns among immune cells for HIV infection in three cohortsZhang X, Hu Y, Vandenhoudt R, Yan C, Marconi V, Cohen M, Wang Z, Justice A, Aouizerat B, Xu K. Computationally inferred cell-type specific epigenome-wide DNA methylation analysis unveils distinct methylation patterns among immune cells for HIV infection in three cohorts. PLOS Pathogens 2024, 20: e1012063. PMID: 38466776, PMCID: PMC10957090, DOI: 10.1371/journal.ppat.1012063.
- Nano-indentation study of dislocation evolution in GaN-based laser diodesChen J, Su X, Wang G, Niu M, Li X, Xu K. Nano-indentation study of dislocation evolution in GaN-based laser diodes. Discover Nano 2024, 19: 40. PMID: 38453741, PMCID: PMC10920521, DOI: 10.1186/s11671-024-03983-0.
- A multi-ancestry genetic study of pain intensity in 598,339 veteransToikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell E, Pavicic M, Sullivan K, Xu K, Jacobson D, Gelernter J, Rentsch C, Stahl E, Cheatle M, Zhou H, Waxman S, Justice A, Kember R, Kranzler H. A multi-ancestry genetic study of pain intensity in 598,339 veterans. Nature Medicine 2024, 30: 1075-1084. PMID: 38429522, DOI: 10.1038/s41591-024-02839-5.
- Microstructural and spectroscopic analysis of epitaxial lateral overgrowth GaN via the self-decomposing hexagonal graphene maskTao J, Xu Y, Li J, Cai X, Wang Y, Wang G, Cao B, Xu K. Microstructural and spectroscopic analysis of epitaxial lateral overgrowth GaN via the self-decomposing hexagonal graphene mask. Japanese Journal Of Applied Physics 2024, 63: 025503. DOI: 10.35848/1347-4065/ad1e88.
- The growth of epitaxial graphene on SiC and its metal intercalation: a reviewYang D, Ma F, Bian X, Xia Q, Xu K, Hu T. The growth of epitaxial graphene on SiC and its metal intercalation: a review. Journal Of Physics Condensed Matter 2024, 36: 173003. PMID: 38237180, DOI: 10.1088/1361-648x/ad201a.
- Dislocation slip systems in c-plane and m-plane AlN single crystals under nano-indentationChen J, Chen K, Su X, Niu M, Wang Q, Xu K. Dislocation slip systems in c-plane and m-plane AlN single crystals under nano-indentation. Thin Solid Films 2024, 791: 140240. DOI: 10.1016/j.tsf.2024.140240.
- Structure and Cathodoluminescence Properties in Tb3+ and Eu3+ Doped AlN FilmsLuo X, Wang X, Meng H, Chen H, Zeng X, Gao X, Mao H, Xu K. Structure and Cathodoluminescence Properties in Tb3+ and Eu3+ Doped AlN Films. Physica Status Solidi (a) – Applications And Materials Science 2023, 221 DOI: 10.1002/pssa.202300625.
- Reply to: Genetic differentiation at probe SNPs leads to spurious results in meQTL discoveryCheng Y, Li B, Zhang X, Aouizerat B, Zhao H, Xu K. Reply to: Genetic differentiation at probe SNPs leads to spurious results in meQTL discovery. Communications Biology 2023, 6: 1296. PMID: 38129596, PMCID: PMC10739901, DOI: 10.1038/s42003-023-05646-9.
- Growth of Single-Crystalline GaN Films on Ga-Free Langasite-Type Crystals by Metal–Organic Chemical Vapor DepositionWang S, Xu J, Wang Y, Su X, Zheng Y, Bao N, Xu K. Growth of Single-Crystalline GaN Films on Ga-Free Langasite-Type Crystals by Metal–Organic Chemical Vapor Deposition. Crystal Growth & Design 2023, 24: 331-338. DOI: 10.1021/acs.cgd.3c01042.
- Vertical GaN-on-GaN Trench Junction Barrier Schottky Diodes With a Slanted SidewallLiu X, Li B, Wu J, Li J, Yue W, Zhu R, Wang Q, Li X, Ben J, He W, Chiu H, Xu K, Zhong Z. Vertical GaN-on-GaN Trench Junction Barrier Schottky Diodes With a Slanted Sidewall. IEEE Journal Of The Electron Devices Society 2023, 12: 34-38. DOI: 10.1109/jeds.2023.3340512.
- Interband transition physics from the absorption edge in GaN: New prospects from numerical analysisHan S, Yi J, Song W, Chen K, Zheng S, Zhang Y, Xu K. Interband transition physics from the absorption edge in GaN: New prospects from numerical analysis. AIP Advances 2023, 13: 125016. DOI: 10.1063/5.0180220.
- Optimized design of single trench termination combined with P-type buried layers for power MOSFETsWang X, Zhou J, Zhang Y, Wang J, Xu K. Optimized design of single trench termination combined with P-type buried layers for power MOSFETs. 2023, 00: 165-168. DOI: 10.1109/sslchinaifws60785.2023.10399693.
- Epitaxial Growth of High-Quality GaN Films Based on Bilayer GrapheneZhou J, Xu Y, Wang X, Wang Y, Yue L, Wang J, Cao B, Xu K. Epitaxial Growth of High-Quality GaN Films Based on Bilayer Graphene. 2023, 00: 161-164. DOI: 10.1109/sslchinaifws60785.2023.10399753.
- Trans-ancestry epigenome-wide association meta-analysis of DNA methylation with lifetime cannabis useFang F, Quach B, Lawrence K, van Dongen J, Marks J, Lundgren S, Lin M, Odintsova V, Costeira R, Xu Z, Zhou L, Mandal M, Xia Y, Vink J, Bierut L, Ollikainen M, Taylor J, Bell J, Kaprio J, Boomsma D, Xu K, Sandler D, Hancock D, Johnson E. Trans-ancestry epigenome-wide association meta-analysis of DNA methylation with lifetime cannabis use. Molecular Psychiatry 2023, 29: 124-133. PMID: 37935791, PMCID: PMC11078760, DOI: 10.1038/s41380-023-02310-w.
- Defect evolution in GaN thin film heterogeneously integrated with CMOS-compatible Si(100) substrate by ion-cutting technologyShi H, Yi A, Ding J, Liu X, Qin Q, Yi J, Hu J, Wang M, Cai D, Wang J, Xu K, Mu F, Suga T, Heller R, Wang M, Zhou S, Xu W, Huang K, You T, Ou X. Defect evolution in GaN thin film heterogeneously integrated with CMOS-compatible Si(100) substrate by ion-cutting technology. Science China Information Sciences 2023, 66: 219403. DOI: 10.1007/s11432-022-3668-0.
- 78. NETWORK BIOLOGY ALGORITHMS IDENTIFY BIOLOGICAL PATHWAYS UNDERLYING CIGARETTE SMOKING BEHAVIORSSullivan K, Miller J, Kainer D, Lane M, Cashman M, Garvin M, Townsend A, Kruse P, Quach B, Willis C, Xu K, Aouzierat B, Johnson E, Hancock D, Jacobson D. 78. NETWORK BIOLOGY ALGORITHMS IDENTIFY BIOLOGICAL PATHWAYS UNDERLYING CIGARETTE SMOKING BEHAVIORS. European Neuropsychopharmacology 2023, 75: s98-s99. DOI: 10.1016/j.euroneuro.2023.08.183.
- Impacts of Alcohol Misuse on DNA Methylation and Epigenetic Age in Two Distinct PopulationsXu K, Liang X, Justice A, So-Armah K, Bradley B, Sinha R. Impacts of Alcohol Misuse on DNA Methylation and Epigenetic Age in Two Distinct Populations. Biological Psychiatry 2023, 93: s29-s30. DOI: 10.1016/j.biopsych.2023.02.090.
Clinical Trials
Conditions | Study Title |
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Addictive Behaviors; Child Development & Autism; Mental Health & Behavioral Research | A longitudinal study of the effects of cannabis exposure on neuro-development in adolescents and young adults |