Julien Berro, PhD
Associate Professor of Molecular Biophysics and Biochemistry, and of Cell Biology
Research & Publications
Biography
News
Research Summary
The Berro lab is interested in unraveling the molecular and biophysical mechanisms of clathrin-mediated endocytosis. We use a cross-disciplinary approach combining experimental work (genetics, cell biology, quantitative live fluorescence microscopy) and computational tools (image analysis, mathematical modeling). The Berro lab is also interested in the development of new methods for in vivo Biochemistry and Systems Biology.
Coauthors
Research Interests
Biophysics; Cell Biology; Cytoskeleton; Endocytosis; Kinetics; Microscopy; Microscopy, Fluorescence; Models, Theoretical; Schizosaccharomyces; Nonlinear Dynamics; Microscopy, Confocal; Mechanics; Systems Biology; Mathematical Concepts; Machine Learning; Single Molecule Imaging
Research Image
Endocytosis from Lacy et al 2018
Selected Publications
- Force redistribution in clathrin-mediated endocytosis revealed by coiled-coil force sensorsRen Y, Yang J, Fujita B, Jin H, Zhang Y, Berro J. Force redistribution in clathrin-mediated endocytosis revealed by coiled-coil force sensors. Science Advances 2023, 9: eadi1535. PMID: 37831774, PMCID: PMC10575576, DOI: 10.1126/sciadv.adi1535.
- 2A peptide from ERBV-1 efficiently separates endogenous protein domains in the fission yeast Schizosaccharomyces pombeRen Y, Lin Q, Berro J. 2A peptide from ERBV-1 efficiently separates endogenous protein domains in the fission yeast Schizosaccharomyces pombe. MicroPublication Biology 2023, 2023: 10.17912/micropub.biology.000941. PMID: 37767365, PMCID: PMC10520729, DOI: 10.17912/micropub.biology.000941.
- Crosslinking actin networks produces compressive forceMa R, Berro J. Crosslinking actin networks produces compressive force. Cytoskeleton 2019, 76: 346-354. PMID: 31278856, PMCID: PMC7001507, DOI: 10.1002/cm.21552.
- “Essentially, all models are wrong, but some are useful”—a cross-disciplinary agenda for building useful models in cell biology and biophysicsBerro J. “Essentially, all models are wrong, but some are useful”—a cross-disciplinary agenda for building useful models in cell biology and biophysics. Biophysical Reviews 2018, 10: 1637-1647. PMID: 30421276, PMCID: PMC6297095, DOI: 10.1007/s12551-018-0478-4.
- Molecular mechanisms of force production in clathrin‐mediated endocytosisLacy MM, Ma R, Ravindra NG, Berro J. Molecular mechanisms of force production in clathrin‐mediated endocytosis. FEBS Letters 2018, 592: 3586-3605. PMID: 30006986, PMCID: PMC6231980, DOI: 10.1002/1873-3468.13192.
- Quantitative Biology of EndocytosisBerro J, Lacy M. Quantitative Biology of Endocytosis. Colloquium Series On Quantitative Cell Biology 2018, 4: i-74. DOI: 10.4199/c00164ed1v01y201805qcb004.
- Structural organization and energy storage in crosslinked actin assembliesMa R, Berro J. Structural organization and energy storage in crosslinked actin assemblies. PLOS Computational Biology 2018, 14: e1006150. PMID: 29813051, PMCID: PMC5993335, DOI: 10.1371/journal.pcbi.1006150.
- Quantitative Biology of Endocytosis.Berro J, Lacy MM. Quantitative Biology of Endocytosis. In: Colloquium Series on Quantitative Cell Biology (Marshall WF, ed). San Rafael (CA): Morgan & Claypool Life Sciences Publishers. doi: 10.4199/C00164ED1V01Y201805QCB004. ISBN: 9781615047864 (hardcover)/ 9781615047840 (paperback) / 9781615047857 (ebook).
- High-speed super-resolution imaging of the proteins in fission yeast clathrin-mediated endocytic actin patchesArasada R, Sayyad WA, Berro J, Pollard TD. High-speed super-resolution imaging of the proteins in fission yeast clathrin-mediated endocytic actin patches. Molecular Biology Of The Cell 2017, 29: mbc.e17-06-0415. PMID: 29212877, PMCID: PMC5996959, DOI: 10.1091/mbc.e17-06-0415.
- Single-molecule imaging of the BAR-domain protein Pil1p reveals filament-end dynamicsLacy MM, Baddeley D, Berro J. Single-molecule imaging of the BAR-domain protein Pil1p reveals filament-end dynamics. Molecular Biology Of The Cell 2017, 28: 2251-2259. PMID: 28659415, PMCID: PMC5555653, DOI: 10.1091/mbc.e17-04-0238.
- How will kinetics and thermodynamics inform our future efforts to understand and build biological systems?Doudna J, Bar-Ziv R, Elf J, Noireaux V, Berro J, Saiz L, Vavylonis D, Faulon JL, Fordyce P. [Perspective] How will kinetics and thermodynamics inform our future efforts to understand and build biological systems? Cell Systems. 2017 Feb 22;4(2):144-146.
- Local and global analysis of endocytic patch dynamics in fission yeast using a new “temporal superresolution” realignment methodBerro J, Pollard TD. Local and global analysis of endocytic patch dynamics in fission yeast using a new “temporal superresolution” realignment method. Molecular Biology Of The Cell 2014, 25: 3501-3514. PMID: 25143395, PMCID: PMC4230612, DOI: 10.1091/mbc.e13-01-0004.
- Synergies between Aip1p and capping protein subunits (Acp1p and Acp2p) in clathrin-mediated endocytosis and cell polarization in fission yeastBerro J, Pollard TD. Synergies between Aip1p and capping protein subunits (Acp1p and Acp2p) in clathrin-mediated endocytosis and cell polarization in fission yeast. Molecular Biology Of The Cell 2014, 25: 3515-3527. PMID: 25143407, PMCID: PMC4230613, DOI: 10.1091/mbc.e13-01-0005.
- Mathematical Modeling of Endocytic Actin Patch Kinetics in Fission Yeast: Disassembly Requires Release of Actin Filament FragmentsBerro J, Sirotkin V, Pollard TD. Mathematical Modeling of Endocytic Actin Patch Kinetics in Fission Yeast: Disassembly Requires Release of Actin Filament Fragments. Molecular Biology Of The Cell 2010, 21: 2905-2915. PMID: 20587776, PMCID: PMC2921120, DOI: 10.1091/mbc.e10-06-0494.
- Quantitative Analysis of the Mechanism of Endocytic Actin Patch Assembly and Disassembly in Fission YeastSirotkin V, Berro J, Macmillan K, Zhao L, Pollard TD. Quantitative Analysis of the Mechanism of Endocytic Actin Patch Assembly and Disassembly in Fission Yeast. Molecular Biology Of The Cell 2010, 21: 2894-2904. PMID: 20587778, PMCID: PMC2921122, DOI: 10.1091/mbc.e10-02-0157.