Henry Yaggi
Research & Publications
Biography
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Research Summary
Dr. Yaggi is an Associate Professor of Medicine at the Yale University School of Medicine and Director of the Yale Program in Sleep Medicine. He is board certified in Internal Medicine, Pulmonary Medicine, Critical Care, and Sleep Medicine. He is a Principal Investigator at the national VA Clinical Epidemiology Research Center. His research interest is the clinical epidemiology of sleep-disordered breathing, with a focus on the diverse health implications of sleep apnea and an emphasis on informing clinical care. Within this larger domain, his work has focused on 3 specific topics: sleep apnea as a risk factor for adverse cardiovascular and metabolic health outcomes; prognostic factors for adverse cardiovascular and metabolic health outcomes in patients with sleep-disordered breathing; and the impact of diagnosing and treating sleep apnea (using home-based strategies) on cardiovascular risk.
Extensive Research Description
Principal Investigator at the national VA Clinical Epidemiology Research Center. His research interest is the clinical epidemiology of sleep-disordered breathing, with a focus on the diverse health implications of sleep apnea and an emphasis on informing clinical care. Within this larger domain, his work has focused on 3 specific topics: sleep apnea as a risk factor for adverse cardiovascular and metabolic health outcomes; prognostic factors for adverse cardiovascular and metabolic health outcomes in patients with sleep-disordered breathing; and the impact of diagnosing and treating sleep apnea (using home-based strategies) on cardiovascular risk.
Agency: VA Clinical Science Research and Develop I.D.# Merit Review Award Title: “Oxygen versus PAP for treatment of sleep apnea in chronic heart failure” P.I.: Yaggi/Gottlieb Role: Principal Investigator Percent effort: 35% Direct costs per year: $250,000 Total costs for project period: $1,500,000 Project period: 10/01/2012 – 09/30/2016
Agency: National institute of Health/National Institute of Nursing Research I.D.# 1P20NR014126-01 Title Yale Center for Sleep Disturbance in Acute and Chronic Conditions P.I. Henry Klar Yaggi, M.D. M.P.H. Percent Effort: 12.5% Direct costs per year: $250,000 Total costs for project period: $1,250,000 Project period: 10/01/2012-9/30/2017
Agency: NIH National Heart Lung and Blood institute (NHLBI) I.D.# U34 HL105285-01 Title: “Sleep Apnea in TIA/ Stroke: Reducing Vascular Risk with CPAP (SLEEP TIGHT)” P.I.: Henry Klar Yaggi, M.D. M.P.H. Percent effort: 30% Direct costs per year: $500,000 Total costs for project period: $2,000,000 Project period: 10/01/2010 – 06/31/2014
Agency: NIH National Heart Lung and Blood institute (NHLBI) I.D.# R21 MD006769 Title: “Multi-Level Modeling of Social Disparities in Sleep and Health” P.I.: Andre Araujo, Ph.D Role: Co-investigator Percent effort: 5% Direct costs per year: $250,000 Total costs for project period: $500,000 Project period: 10/01/2011 – 09/30/2014
Coauthors
Research Interests
Apnea; Arrhythmias, Cardiac; Health Services Administration; Investigative Techniques; Cardiomyopathies; Therapeutics; Health Care
Public Health Interests
Cardiovascular Diseases; Respiratory Disease/Infections
Research Image
pub298w417_594109138-Sleep Apnea
Selected Publications
- Insomnia with objective short sleep duration in community‐living older persons: A multifactorial geriatric health conditionMiner B, Doyle M, Knauert M, Yaggi H, Stone K, Ancoli‐Israel S, Cauley J, Redline S, Blackwell T, Gill T, Groups F. Insomnia with objective short sleep duration in community‐living older persons: A multifactorial geriatric health condition Journal Of The American Geriatrics Society 2022 PMID: 36524599, DOI: 10.1111/jgs.18195.
- The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methodsKoo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods Sleep And Breathing 2015, 20: 893-900. PMID: 26642771, DOI: 10.1007/s11325-015-1254-3.
- Use of Lambda-Mu-Sigma-Derived Z Score for Evaluating Respiratory Impairment in Middle-Aged PersonsFragoso C, Gill TM, McAvay G, Van Ness PH, Yaggi HK, Concato J. Use of Lambda-Mu-Sigma-Derived Z Score for Evaluating Respiratory Impairment in Middle-Aged Persons Respiratory Care 2011, 56: 1771-1777. PMID: 21605489, PMCID: PMC3676885, DOI: 10.4187/respcare.01192.
- Auto-Titrating Continuous Positive Airway Pressure for Patients With Acute Transient Ischemic AttackBravata DM, Concato J, Fried T, Ranjbar N, Sadarangani T, McClain V, Struve F, Zygmunt L, Knight HJ, Lo A, Richerson GB, Gorman M, Williams LS, Brass LM, Agostini J, Mohsenin V, Roux F, Yaggi HK. Auto-Titrating Continuous Positive Airway Pressure for Patients With Acute Transient Ischemic Attack Stroke 2010, 41: 1464-1470. PMID: 20508184, PMCID: PMC4567557, DOI: 10.1161/strokeaha.109.566745.
- The Ratio of FEV1 to FVC as a Basis for Establishing Chronic Obstructive Pulmonary DiseaseVaz Fragoso CA, Concato J, McAvay G, Van Ness PH, Rochester CL, Yaggi HK, Gill TM. The Ratio of FEV1 to FVC as a Basis for Establishing Chronic Obstructive Pulmonary Disease American Journal Of Respiratory And Critical Care Medicine 2009, 181: 446-451. PMID: 20019341, PMCID: PMC3159085, DOI: 10.1164/rccm.200909-1366oc.
- Obstructive Sleep Apnea as a Risk Factor for Type 2 DiabetesBotros N, Concato J, Mohsenin V, Selim B, Doctor K, Yaggi HK. Obstructive Sleep Apnea as a Risk Factor for Type 2 Diabetes The American Journal Of Medicine 2009, 122: 1122-1127. PMID: 19958890, PMCID: PMC2799991, DOI: 10.1016/j.amjmed.2009.04.026.
- The effect of gender on the prevalence of hypertension in obstructive sleep apneaMohsenin V, Yaggi HK, Shah N, Dziura J. The effect of gender on the prevalence of hypertension in obstructive sleep apnea Sleep Medicine 2009, 10: 759-762. PMID: 19185538, DOI: 10.1016/j.sleep.2008.09.005.
- Obstructive Sleep Apnea as a Risk Factor for Stroke and DeathYaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive Sleep Apnea as a Risk Factor for Stroke and Death New England Journal Of Medicine 2005, 353: 2034-2041. PMID: 16282178, DOI: 10.1056/nejmoa043104.
Clinical Trials
Conditions | Study Title |
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Immune System; Men's Health; Women's Health | Effects of circadian regulation and sleep on immune responses |
Diseases of the Cardiovascular System | The Recovery in Stroke Using PAP Study (RISE-UP) |
Diseases of the Cardiovascular System; Diseases of the Nervous System | Sleep for Stroke Management and Recovery Trial (Sleep SMART) |