Andrey Zinchuk, MD, MHS
Assistant Professor; Director, Advanced Apnea Management Program; Director, Yale Sleep Fellowship Didactic and Research Curriculum, Internal Medicine, PCCSM; Director, Upper Airway Neurostimulation Program; Section of Pulmonary, Critical Care and Sleep Medicine
Research & Publications
Biography
News
Research Summary
Research: My goal is to improve the lives of people with sleep-disordered breathing. My colleagues and I aim to make the care of patients with sleep apnea more precise, using the unique physiology, prognosis, and treatment responsiveness of each individual. We anticipate this approach will result in novel, effective, and tolerable treatments.
Extensive Research Description
We conduct NIH-sponsored research to identify physiological characteristics of individuals with sleep apnea that predict the effectiveness of treatment. Many individuals with sleep apnea can not tolerate first-line therapy: continuous positive airway pressure (CPAP). We find that traits such as the ease with which individuals arouse from sleep and the biological clock are key factors in someone's success with CPAP therapy. We aim to use this understanding to personalized approaches to treatment, for example, in those with easy arousability, using medications or non-pharmacological treatments.
We also hope to understand phenotypes of sleep apnea and how they influence incident cardiovascular disease or death. For example, the propensity for oxygen desaturation during an apnea or the heart rate response to an apnea may identify those at most risk for heart disease or death. Understanding these phenotypes can help identify individuals in which sleep apnea treatment may prevent heart disease.
Mentors: Klar Yaggi MD (Yale), Andrew Wellman MD, PhD (Harvard), Scott Sands, PhD (Harvard)
Coauthors
Research Interests
Cardiovascular Diseases; Sleep; Sleep Apnea Syndromes; Polysomnography; Sleep Apnea, Central; Continuous Positive Airway Pressure; Precision Medicine; Endophenotypes
Selected Publications
- 0480 Psychoactive Substance Use and Sleep Characteristics Among Individuals with Untreated Obstructive Sleep ApneaWalker A, Baldassarri S, Chu J, Deng A, Xu Z, Blohowiak R, Byrne S, Kushida C, Yaggi H, Zinchuk A. 0480 Psychoactive Substance Use and Sleep Characteristics Among Individuals with Untreated Obstructive Sleep Apnea. Sleep 2023, 46: a213-a214. DOI: 10.1093/sleep/zsad077.0480.
- 0522 CPAP Improves Cognition in Brain-Healthy Males: Secondary Analysis of a Randomized TrialSun H, Zinchuk A, Locascio J, Kushida C, Thomas R, Westover M. 0522 CPAP Improves Cognition in Brain-Healthy Males: Secondary Analysis of a Randomized Trial. Sleep 2023, 46: a230-a231. DOI: 10.1093/sleep/zsad077.0522.
- 0872 Periodic limb movements during sleep and hypertension: A systematic review and meta-analysisSrivali N, Thongprayoon C, Tangpanithandee S, Krisanapan P, Zinchuk A, Koo B, Cheungpasitporn W. 0872 Periodic limb movements during sleep and hypertension: A systematic review and meta-analysis. Sleep 2023, 46: a384-a384. DOI: 10.1093/sleep/zsad077.0872.
- Nicotine, alcohol, and caffeine use among individuals with untreated obstructive sleep apneaBaldassarri S, Chu J, Deng A, Xu Z, Blohowiak R, Byrne S, Kushida C, Yaggi H, Zinchuk A. Nicotine, alcohol, and caffeine use among individuals with untreated obstructive sleep apnea. Sleep And Breathing 2023, 1-12. PMID: 37058215, DOI: 10.1007/s11325-023-02830-3.
- Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea.Knauert M, Adekolu O, Xu Z, Deng A, Chu J, Baldassarri S, Kushida C, Yaggi H, Zinchuk A. Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2023 PMID: 36917194, DOI: 10.1513/annalsats.202210-885oc.
- Periodic limb movements during sleep and risk of hypertension: A systematic reviewSrivali N, Thongprayoon C, Tangpanithandee S, Krisanapan P, Mao M, Zinchuk A, Koo B, Cheungpasitporn W. Periodic limb movements during sleep and risk of hypertension: A systematic review. Sleep Medicine 2023, 102: 173-179. PMID: 36701831, DOI: 10.1016/j.sleep.2023.01.008.
- Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness.Azarbarzin A, Zinchuk A, Wellman A, Labarca G, Vena D, Gell L, Messineo L, White DP, Gottlieb DJ, Redline S, Peker Y, Sands SA. Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 767-774. PMID: 35579605, PMCID: PMC9799106, DOI: 10.1164/rccm.202111-2608oc.
- Sleep Deficiency in Obstructive Sleep ApneaAdekolu O, Zinchuk A. Sleep Deficiency in Obstructive Sleep Apnea. Clinics In Chest Medicine 2022, 43: 353-371. PMID: 35659030, PMCID: PMC9351701, DOI: 10.1016/j.ccm.2022.02.013.
- 0158 Risk perception, outcome expectancy, and treatment self-efficacy among women and men with obstructive sleep apnea (OSA)Sharma A, Byrne S, Deng A, Chu J, Sands S, Wellman A, Redeke N, Yaggi H, Zinchuk A. 0158 Risk perception, outcome expectancy, and treatment self-efficacy among women and men with obstructive sleep apnea (OSA). Sleep 2022, 45: a73-a73. DOI: 10.1093/sleep/zsac079.156.
- 0790 Racial Differences in Self-Efficacy for Positive Airway Pressure Therapy Among Individuals Newly Diagnosed with Obstructive Sleep ApneaByrne S, Sharma A, Deng A, Chu J, Sands S, Wellman A, Redeker N, Yaggi H, Zinchuk A. 0790 Racial Differences in Self-Efficacy for Positive Airway Pressure Therapy Among Individuals Newly Diagnosed with Obstructive Sleep Apnea. Sleep 2022, 45: a343-a343. DOI: 10.1093/sleep/zsac079.786.
- Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study.Ding Q, Qin L, Wojeck B, Inzucchi SE, Ibrahim A, Bravata DM, Strohl KP, Yaggi HK, Zinchuk AV. Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes: Results from the DREAM Study. Annals Of The American Thoracic Society 2021, 18: 2067-2078. PMID: 34185617, PMCID: PMC8641817, DOI: 10.1513/annalsats.202012-1556oc.
- Physiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease.Zinchuk AV, Chu JH, Liang J, Celik Y, Op de Beeck S, Redeker NS, Wellman A, Yaggi HK, Peker Y, Sands SA. Physiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease. American Journal Of Respiratory And Critical Care Medicine 2021, 204: 703-712. PMID: 34156917, PMCID: PMC8521693, DOI: 10.1164/rccm.202101-0055oc.
- 441 Influence Of Chronotype On CPAP AdherenceAdekolu O, Xu Z, Chu J, Kushida C, Yaggi H, Knauert M, Zinchuk A. 441 Influence Of Chronotype On CPAP Adherence. Sleep 2021, 44: a174-a175. DOI: 10.1093/sleep/zsab072.440.
- Cardiovascular Benefit of CPAP Is Modified by the Sleep Apnea Related Pulse Rate Response in Coronary Artery Disease Patients with Nonsleepy OSA: Findings from the RICCADSA Randomized Controlled TrialAzarbarzin A, Zinchuk A, Wellman D, Taranto Montemurro L, Vena D, Gell L, Messineo L, White D, Gottlieb D, Redline S, Peker Y, Sands S. Cardiovascular Benefit of CPAP Is Modified by the Sleep Apnea Related Pulse Rate Response in Coronary Artery Disease Patients with Nonsleepy OSA: Findings from the RICCADSA Randomized Controlled Trial. 2021, a1103-a1103. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1103.
- Associations Between Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 DiabetesDing Q, Qin L, Wojeck B, Inzucchi S, Ibrahim A, Bravata D, Strohl K, Yaggi H, Zinchuk A. Associations Between Polysomnographic Phenotypes of Obstructive Sleep Apnea and Incident Type 2 Diabetes. 2021, a4679-a4679. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4679.
- Treatment-Emergent Central Sleep ApneaZinchuk A, Yaggi H. Treatment-Emergent Central Sleep Apnea. 2021, 85-102. DOI: 10.1007/978-3-030-57942-5_8.
- Correlates of sleep quality and excessive daytime sleepiness in people with opioid use disorder receiving methadone treatmentBaldassarri SR, Beitel M, Zinchuk A, Redeker NS, Oberleitner DE, Oberleitner LMS, Carrasco D, Madden LM, Lipkind N, Fiellin DA, Bastian LA, Chen K, Yaggi HK, Barry DT. Correlates of sleep quality and excessive daytime sleepiness in people with opioid use disorder receiving methadone treatment. Sleep And Breathing 2020, 24: 1729-1737. PMID: 32556918, PMCID: PMC7680294, DOI: 10.1007/s11325-020-02123-z.
- Physiological Traits and Adherence to Obstructive Sleep Apnea Treatment in Patients with StrokeZinchuk AV, Redeker NS, Chu JH, Liang J, Stepnowsky C, Brandt CA, Bravata DM, Wellman A, Sands SA, Yaggi HK. Physiological Traits and Adherence to Obstructive Sleep Apnea Treatment in Patients with Stroke. American Journal Of Respiratory And Critical Care Medicine 2020, 0: 1568-1572. PMID: 32083949, PMCID: PMC7301748, DOI: 10.1164/rccm.201911-2203le.
- Update in Sleep in 2019Leary EB, Zinchuk A, Stone KL, Mehra R. Update in Sleep in 2019. American Journal Of Respiratory And Critical Care Medicine 2020, 0: 1473-1479. PMID: 32293912, DOI: 10.1164/rccm.202003-0586up.
- 0568 Physiologic OSA Traits and CPAP Adherence Among Patients with Coronary Artery Disease and OSAZinchuk A, Yaggi H, Liang J, Chu J, Op De Beeck S, Stepnowski C, Wellman A, Peker Y, Sands S. 0568 Physiologic OSA Traits and CPAP Adherence Among Patients with Coronary Artery Disease and OSA. Sleep 2020, 43: a218-a218. DOI: 10.1093/sleep/zsaa056.565.
- Physiologic Traits Predict Therapeutic Pressure Requirements and Residual Respiratory Events Among Patients with Coronary Artery Disease and Obstructive Sleep ApneaZinchuk A, Yaggi H, Liang J, Chu J, Op de Beeck S, Stepnowsky C, Wellman D, Peker Y, Sands S. Physiologic Traits Predict Therapeutic Pressure Requirements and Residual Respiratory Events Among Patients with Coronary Artery Disease and Obstructive Sleep Apnea. 2020, a6439-a6439. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6439.
- Introduction to Sleep Breathing DisordersZinchuk, A., Thomas, R. “Introduction to Sleep Breathing Disorders,“ in Principles and Practice of Sleep Medicine (Seventh Edition), Meir H. Kryger, Thomas Roth, and William C. Dement; Saunders, 2020
- Central Sleep Apnea: Diagnosis and TreatmentZinchuk, A., Thomas, R. “Central Sleep Apnea: Diagnosis and Treatment,“ in Principles and Practice of Sleep Medicine (Seventh Edition), Meir H. Kryger, Thomas Roth, and William C. Dement; Saunders, 2020
- The Arousal Threshold as a Drug-Target to Improve CPAP Adherence: Secondary Analysis of a Randomized TrialZinchuk A. The Arousal Threshold as a Drug-Target to Improve CPAP Adherence: Secondary Analysis of a Randomized Trial. PracticeUpdate website. Available at: https://www.practiceupdate.com/content/the-arousal-threshold-as-a-drug-target-to-improve-cpap-adherence/103953/65/20/1. Aug 7, 2020
- Phenotypic Subtypes of OSA A Challenge and Opportunity for Precision MedicineZinchuk A, Yaggi HK. Phenotypic Subtypes of OSA A Challenge and Opportunity for Precision Medicine. CHEST Journal 2019, 157: 403-420. PMID: 31539538, PMCID: PMC7005379, DOI: 10.1016/j.chest.2019.09.002.
- Sleep Apnea Heterogeneity, Phenotypes, and Cardiovascular Risk. Implications for Trial Design and Precision Sleep MedicineZinchuk A, Yaggi HK. Sleep Apnea Heterogeneity, Phenotypes, and Cardiovascular Risk. Implications for Trial Design and Precision Sleep Medicine. American Journal Of Respiratory And Critical Care Medicine 2019, 200: 412-413. PMID: 30916985, PMCID: PMC6701039, DOI: 10.1164/rccm.201903-0545ed.
- Low Arousal Threshold Correlates with Reduced Continuous Positive Airway Pressure Use in Non-Obese Individuals with Obstructive Sleep Apnea and StrokeZinchuk A, Yaggi H, Concato J, Jeon S, Bravata D, Wellman D, Sands S. Low Arousal Threshold Correlates with Reduced Continuous Positive Airway Pressure Use in Non-Obese Individuals with Obstructive Sleep Apnea and Stroke. 2019, a2598-a2598. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2598.
- Effect of Arousal Scoring on Reliability of Automated, Non-Invasive Phenotyping of Physiologic Sleep Apnea Traits from PolysomnographyZinchuk A, Yaggi H, Concato J, Wellman D, Smales E, Hess L, Denos J, Peker Y, Sands S. Effect of Arousal Scoring on Reliability of Automated, Non-Invasive Phenotyping of Physiologic Sleep Apnea Traits from Polysomnography. 2019, a7078-a7078. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7078.
- Shared Genetic Architecture Between Sleep and Blood Pressure Traits in HumansCade B, Lee J, Gharib S, Gottlieb D, He K, Hillman D, Liang J, Mukherjee S, Palmer L, Sofer T, Wang H, Zinchuk A, Saxena R, Purcell S, Zhu X, Redline S. Shared Genetic Architecture Between Sleep and Blood Pressure Traits in Humans. 2019, a7259-a7259. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7259.
- Treatment Emergent Central Sleep ApneaZinchuk, A. Yaggi, K. “Treatment Emergent Central Sleep Apnea” in Complex Sleep Breathing Disorders (1st Edition), edited by Christine Won; Springer Nature, 2019
- Prevalence, Associated Clinical Features, and Impact on Continuous Positive Airway Pressure Use of a Low Respiratory Arousal Threshold Among Male United States Veterans With Obstructive Sleep Apnea.Zinchuk A, Edwards BA, Jeon S, Koo BB, Concato J, Sands S, Wellman A, Yaggi HK. Prevalence, Associated Clinical Features, and Impact on Continuous Positive Airway Pressure Use of a Low Respiratory Arousal Threshold Among Male United States Veterans With Obstructive Sleep Apnea. Journal Of Clinical Sleep Medicine 2018, 14: 809-817. PMID: 29734986, PMCID: PMC5940432, DOI: 10.5664/jcsm.7112.
- 0574 A Composite Model of Commonly Derived Polysomnographic Variables Predicts Risk of Cardiovascular Outcomes Better than the Apnea Hypopnea Index AloneTrivedi V, Zinchuk A, Qin L, Bravata D, Strohl K, Selim B, Yaggi H. 0574 A Composite Model of Commonly Derived Polysomnographic Variables Predicts Risk of Cardiovascular Outcomes Better than the Apnea Hypopnea Index Alone. Sleep 2018, 41: a213-a214. DOI: 10.1093/sleep/zsy061.573.
- 0466 High Frequency Of PLMS Is Associated With Increased Risk Of Incident Adverse Cardiovascular Events And Death Among OSA PatientsZinchuk A, Jeon S, Yaggi H. 0466 High Frequency Of PLMS Is Associated With Increased Risk Of Incident Adverse Cardiovascular Events And Death Among OSA Patients. Sleep 2018, 41: a176-a176. DOI: 10.1093/sleep/zsy061.465.
- A Young Man With Hemoptysis and Cavitary Lung LesionsBrady VA, Zinchuk AV, Siegel MD, Possick JD. A Young Man With Hemoptysis and Cavitary Lung Lesions. CHEST Journal 2018, 153: e85-e88. PMID: 29626974, PMCID: PMC6026285, DOI: 10.1016/j.chest.2017.09.018.
- Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoeaZinchuk AV, Jeon S, Koo BB, Yan X, Bravata DM, Qin L, Selim BJ, Strohl KP, Redeker NS, Concato J, Yaggi HK. Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea. Thorax 2017, 73: 472. PMID: 28935698, PMCID: PMC6693344, DOI: 10.1136/thoraxjnl-2017-210431.
- 0533 AROUSAL THRESHOLD, OBESITY, AGE AND RACE PREDICT CONTINUOUS POSITIVE AIRWAY PRESSURE USE AMONG U.S. VETERANS WITH OBSTRUCTIVE SLEEP APNEAZinchuk A, Jeon S, Edwards B, Yaggi K. 0533 AROUSAL THRESHOLD, OBESITY, AGE AND RACE PREDICT CONTINUOUS POSITIVE AIRWAY PRESSURE USE AMONG U.S. VETERANS WITH OBSTRUCTIVE SLEEP APNEA. Sleep 2017, 40: a198-a199. DOI: 10.1093/sleepj/zsx050.532.
- Chapter 110 Central Sleep Apnea Diagnosis and ManagementZinchuk A, Thomas R. Chapter 110 Central Sleep Apnea Diagnosis and Management. 2017, 1059-1075.e6. DOI: 10.1016/b978-0-323-24288-2.00110-0.
- Phenotypes in obstructive sleep apnea: A definition, examples and evolution of approachesZinchuk AV, Gentry MJ, Concato J, Yaggi HK. Phenotypes in obstructive sleep apnea: A definition, examples and evolution of approaches. Sleep Medicine Reviews 2016, 35: 113-123. PMID: 27815038, PMCID: PMC5389934, DOI: 10.1016/j.smrv.2016.10.002.
- The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study.Selim BJ, Koo BB, Qin L, Jeon S, Won C, Redeker NS, Lampert RJ, Concato JP, Bravata DM, Ferguson J, Strohl K, Bennett A, Zinchuk A, Yaggi HK. The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study. Journal Of Clinical Sleep Medicine 2016, 12: 829-37. PMID: 26951420, PMCID: PMC4877315, DOI: 10.5664/jcsm.5880.
- Erratum to: The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methodsKoo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. Erratum to: The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep And Breathing 2016, 20: 901-901. PMID: 26971325, DOI: 10.1007/s11325-016-1329-9.
- Central Sleep Apnea: Diagnosis and TreatmentZinchuk, A., Thomas, R. “Central Sleep Apnea: Diagnosis and Treatment,“ in Principles and Practice of Sleep Medicine (Sixth Edition), Meir H. Kryger, Thomas Roth, and William C. Dement; Saunders, 2016.
- Arts, Sleep and MedicineZinchuk, A., Kryger, M. “Arts, Sleep and Medicine,” American Thoracic Society Podcast Series, 2016, http://www.thoracic.org/about/ats-podcasts/interview-with-professor-dr-meir-h-kryger.php
- The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methodsKoo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep And Breathing 2015, 20: 893-900. PMID: 26642771, DOI: 10.1007/s11325-015-1254-3.
- Synchronous pulmonary malignancies: atypical presentation of mantle cell lymphoma masking a lung malignancyMasha L, Zinchuk A, Boosalis V. Synchronous pulmonary malignancies: atypical presentation of mantle cell lymphoma masking a lung malignancy. Rare Tumors 2015, 7: 5929. PMID: 26500732, PMCID: PMC4600994, DOI: 10.4081/rt.2015.5929.
- Simultaneous Mantle Cell Lymphoma and Undifferentiated Carcinoma Manifested by Pleural Studding and EffusionZinchuk A, Saukkonen J, Boosalis V, Brahma P. Simultaneous Mantle Cell Lymphoma and Undifferentiated Carcinoma Manifested by Pleural Studding and Effusion. CHEST Journal 2013, 144: 597a-597b. DOI: 10.1378/chest.1702019.
- Attitudes of US medical trainees towards neurology education: "Neurophobia" - a global issueZinchuk AV, Flanagan EP, Tubridy NJ, Miller WA, McCullough LD. Attitudes of US medical trainees towards neurology education: "Neurophobia" - a global issue. BMC Medical Education 2010, 10: 49. PMID: 20573257, PMCID: PMC2900283, DOI: 10.1186/1472-6920-10-49.
- Ionization States in the Microenvironment of Solid Dosage Forms: Effect of Formulation Variables and ProcessingGovindarajan R, Zinchuk A, Hancock B, Shalaev E, Suryanarayanan R. Ionization States in the Microenvironment of Solid Dosage Forms: Effect of Formulation Variables and Processing. Pharmaceutical Research 2006, 23: 2454-2468. PMID: 16933092, DOI: 10.1007/s11095-006-9085-3.
- The influence of measurement conditions on the Hammett acidity function of solid pharmaceutical excipientsZinchuk AV, Hancock BC, Shalaev EY, Reddy RD, Govindarajan R, Novak E. The influence of measurement conditions on the Hammett acidity function of solid pharmaceutical excipients. European Journal Of Pharmaceutics And Biopharmaceutics 2005, 61: 158-170. PMID: 16005194, DOI: 10.1016/j.ejpb.2005.04.008.
- Simulation of roller compaction using a laboratory scale compaction simulatorZinchuk AV, Mullarney MP, Hancock BC. Simulation of roller compaction using a laboratory scale compaction simulator. International Journal Of Pharmaceutics 2004, 269: 403-415. PMID: 14706252, DOI: 10.1016/j.ijpharm.2003.09.034.
- The relative density of pharmaceutical powders, blends, dry granulations and immediate release tabletsHancock, B.C., Colvin, J.T., Mullarney, M.P., Zinchuk, A.V., “The relative density of pharmaceutical powders, blends, dry granulations and immediate release tablets,” Pharmaceutical Technology, April 2003, 64-80