Dennis Spencer, MD
Research & Publications
Biography
News
Research Summary
Dr. Spencer's research has brought together basic scientists and clinicians around a program concerning energetics, glutamate metabolism and the neurobiological study of human epileptogenic tissue. Study techniques include 4T MRS, C13 intraoperative glucose turnover studies, and in vivo and in vitro electrophysiology and microdialysis, immunohistochemistry, confocal and EM microscopy, and molecular biology. In particular, laboratory discoveries are correlated with the epileptogenic substrate in order to help define human epilepsy pathogenesis and potential therapies.Recently his research centers around a team effort with Hitten Zaveri of Neurology and Mark Reed of Engineering designing the next generation of multimodal, neurochemistry probes for Brain injury, vascular disease and epilepsy. With Dr Zaveri he pursues wireless transmission of intracranial signals and cooling of the brain. With Tore End of laboratory medicine he studies cerebral metabolism and with Pue Farooque of Neurology, cerebral networks associated with epilepsy.
Specialized Terms: Cerebral metabolic abnormalities that sustain epileptogenesis using MR spectroscopy, Microdialysis, and human tissue studies
Coauthors
Research Interests
Electrophysiology; Epilepsy; Immunohistochemistry; Microscopy, Electron; Molecular Biology; Neurobiology; Neurosurgery; Magnetic Resonance Spectroscopy; Pituitary Neoplasms; Microdialysis; Microscopy, Confocal
Selected Publications
- Combined neuromodulation and resection for functional cortex epilepsy: a case series.Merenzon M, Sivaraju A, Herlopian A, Gerrard J, Quraishi I, Hirsch L, Spencer D, Damisah E. Combined neuromodulation and resection for functional cortex epilepsy: a case series. Journal Of Neurosurgery 2024, 1-9. PMID: 38848588, DOI: 10.3171/2024.3.jns24122.
- A CMOS Nanosensing System For Continuous Brain Multianalyte MonitoringGu Y, Vazquez J, Murray D, Zaveri H, Spencer D. A CMOS Nanosensing System For Continuous Brain Multianalyte Monitoring. 2024, 00: 693-697. DOI: 10.1109/ectc51529.2024.00113.
- Optimized Multilayer Perceptron for Sensorimotor Functional Mapping Based on a Few Minutes of Intracranial Electroencephalogram DataIktimal A, Spencer D, Alkawadri R. Optimized Multilayer Perceptron for Sensorimotor Functional Mapping Based on a Few Minutes of Intracranial Electroencephalogram Data. Annals Of Neurology 2024, 96: 187-193. PMID: 38506405, DOI: 10.1002/ana.26915.
- Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedomSivaraju A, Quraishi I, Collins E, McGrath H, Ramos A, Turk-Browne N, Zaveri H, Damisah E, Spencer D, Hirsch L. Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom. Brain Stimulation 2024, 17: 339-345. PMID: 38490472, DOI: 10.1016/j.brs.2024.03.011.
- Functional parcellation of the cingulate gyrus by electrical cortical stimulation: a synthetic literature review and future directionsMahgoub R, Bayram A, Spencer D, Alkawadri R. Functional parcellation of the cingulate gyrus by electrical cortical stimulation: a synthetic literature review and future directions. Journal Of Neurology Neurosurgery & Psychiatry 2024, jnnp-2023-332246. PMID: 38242679, DOI: 10.1136/jnnp-2023-332246.
- Comparison of Machine Learning Algorithms for Somatosensory Functional Mapping (S30.010)Alwan I, Spencer D, Alkawadri R. Comparison of Machine Learning Algorithms for Somatosensory Functional Mapping (S30.010). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000203115.
- Comparison of Responsive Neurostimulation System Efficacy Between Different Electrographic Seizure Onset Patterns (1255)Henriquez-Rojas P, Torabi T, Farooque P, Hirsch L, Duckrow R, Herlopian A, Spencer D, Gerrard J, Quraishi I. Comparison of Responsive Neurostimulation System Efficacy Between Different Electrographic Seizure Onset Patterns (1255). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.1255.
- Glossokinetic Potentials: Insights from intracranial EEG (P4.5-014)Bayram A, Spencer D, Alkawadri R. Glossokinetic Potentials: Insights from intracranial EEG (P4.5-014). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.p4.5-014.
- Brief History of Electrical Cortical Stimulation: A Journey in time from Volta to Penfield (P5.299)Isitan C, Benjamin C, Quraishi I, Spencer D, Alkawadri R. Brief History of Electrical Cortical Stimulation: A Journey in time from Volta to Penfield (P5.299). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p5.299.
- Effect of Anesthesia on Electrocorticography for localization of Epileptic Focus: Literature Review and Future Directions (P2.271)Bayram A, Rao S, Spencer D, Alkawadri R. Effect of Anesthesia on Electrocorticography for localization of Epileptic Focus: Literature Review and Future Directions (P2.271). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p2.271.
- Long-term Postoperative Outcomes in Patients with Focal Cortical Dysplasia: Predictive Factors and AED Withdrawal (P4.107)Farooque P, Stanford E, Rechnitzer A, Bandt K, Bonito J, Spencer D, Hirsch L. Long-term Postoperative Outcomes in Patients with Focal Cortical Dysplasia: Predictive Factors and AED Withdrawal (P4.107). Neurology 2017, 88 DOI: 10.1212/wnl.88.16_supplement.p4.107.
- Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsyEid T, Hammer J, Rundén-Pran E, Roberg B, Thomas MJ, Osen K, Davanger S, Laake P, Torgner IA, Lee TS, Kim JH, Spencer DD, Ottersen OP, de Lanerolle NC. Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy. Acta Neuropathologica 2006, 113: 137-152. PMID: 17115168, DOI: 10.1007/s00401-006-0158-5.
- Differential Glutamate Dehydrogenase (GDH) Activity Profile in Patients with Temporal Lobe EpilepsyMalthankar‐Phatak G, De Lanerolle N, Eid T, Spencer DD, Behar KL, Spencer SS, Kim JH, Lai JC. Differential Glutamate Dehydrogenase (GDH) Activity Profile in Patients with Temporal Lobe Epilepsy. Epilepsia 2006, 47: 1292-1299. PMID: 16922873, DOI: 10.1111/j.1528-1167.2006.00543.x.
- Nonrigid 3D Brain Registration Using Intensity/Feature InformationDeLorenzo C, Papademetris X, Wu K, Vives KP, Spencer D, Duncan JS. Nonrigid 3D Brain Registration Using Intensity/Feature Information. 2006, 9: 932-939. PMID: 17354980, PMCID: PMC2864121, DOI: 10.1007/11866565_114.
- Interhemispheric commissurotomy for congenital hemiplegics with intractable epilepsy.Goodman R, Williamson P, Reeves A, Spencer S, Spencer D, Mattson R, Roberts D. Interhemispheric commissurotomy for congenital hemiplegics with intractable epilepsy. Neurology 1985, 35: 1351-4. PMID: 4022384, DOI: 10.1212/wnl.35.9.1351.
- Intracerebral masses in patients with intractable partial epilepsy.Spencer D, Spencer S, Mattson R, Williamson P. Intracerebral masses in patients with intractable partial epilepsy. Neurology 1984, 34: 432-6. PMID: 6422323, DOI: 10.1212/wnl.34.4.432.
- Sexual automatisms in complex partial seizures.Spencer S, Spencer D, Williamson P, Mattson R. Sexual automatisms in complex partial seizures. Neurology 1983, 33: 527-33. PMID: 6682492, DOI: 10.1212/wnl.33.5.527.
Clinical Trials
Conditions | Study Title |
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Diseases of the Nervous System; Mental Health & Behavioral Research | SV2A PET Imaging in Healthy Subjects and Epilepsy Patients |