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David Matuskey, MD

Associate Professor of Radiology and Biomedical Imaging; Director, NeuroPET Imaging Program, Radiology and Biomedical Imaging; Medical Director, Yale Positron Emission Tomography (PET) Center

Research Summary

I am a board certified psychiatrist and neuropsychiatrist with research work that has been translational in nature and focused on elucidating the underlying pathology of conditions such as Autism Spectrum Disorder, substance abuse and Parkinson's disease with an aim to find effective clinical treatments guided by molecular neuroimaging. Studies have included using in-vivo PET imaging to investigate the role of receptors such as dopamine D3, serotonin 1B and 6, MGlur5 and kappa, neuroinflammation, and most recently, synaptic density (SV2A) in clinical and nonclinical populations. Ongoing interests include imaging addiction and neuropsychiatric disorders and demographic, social and environmental factors influencing our brain.

Coauthors

Research Interests

Autistic Disorder; Mental Disorders; Parkinson Disease; Social Class; Meditation; Essential Tremor; Molecular Imaging; Frontotemporal Dementia; Neuropsychiatry; Neuroimaging; Addiction Medicine

Public Health Interests

Global Health; Mental Health

Selected Publications

Clinical Trials

ConditionsStudy Title
Mental Health & Behavioral ResearchM1 Schizophrenia PET Study
Diseases of the Nervous SystemMeditation and Synaptic Density
Diseases of the Nervous SystemStudy of Safety and of the Mechanism of BLZ945 in ALS Patients
Alzheimer's Disease; Mental Health & Behavioral ResearchKetamine for the Treatment of Depression in Parkinson's Disease
Alzheimer's DiseaseAHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid
Mental Health & Behavioral ResearchHPA axis function in the brains of PTSD, Trauma Exposed, or Otherwise Healthy research participants utilizing PET and MRI imaging
Diseases of the Endocrine System; Genetics - AdultA Phase I/II Study of VTX-801 in Adult Patients With Wilson's Disease (GATEWAY)
COVID-19 Inpatient; COVID-19 Outpatient; Diseases of the Nervous System; HIV/AIDS; Infectious DiseasesHIV Associated Reservoirs and Comorbidities (The HARC Plus Study)
Addictive BehaviorsPET Imaging of Microglia with [11C]PBR28 in Opioid Dependent and Healthy Control Subjects
Mental Health & Behavioral ResearchEligibility for Participation in Neuroimaging Studies
Child Development & AutismPET Imaging Study for Young Adults with ASD
Diseases of the Nervous SystemImaging the Dopamine Transporter in Parkinson's Disease
Addictive Behaviors; Mental Health & Behavioral Research; Tobacco AddictionImaging smoking-induced dopamine release utilizing PET imaging and nicotine patches
Mental Health & Behavioral ResearchMechanistic Evaluation of Guanfacine on Drinking Behavior
Addictive BehaviorsImaging Synaptic Density in Cocaine and Opiate Addiction In Vivo using 11C-UCB-J PET
Diseases of the Nervous System; Mental Health & Behavioral ResearchExamination of Glutamate and mGluR5 in Psychiatric Disorders
Mental Health & Behavioral ResearchVitamin D as a Therapeutic Adjunct in the Stimulant Treatment of ADHD
Diseases of the Nervous SystemImaging pancreatic beta-cells with PET neuroimaging agent 11C-PHNO
Mental Health & Behavioral ResearchImaging mGluR5 and synaptic density in psychiatric disorders
Mental Health & Behavioral ResearchImaging SV2A in mood disorders