Christine Won
MD, MSc, BA
Associate Professor of Medicine (Pulmonary); Medical Director, Yale Centers for Sleep Medicine; Director, Women's Sleep Health Program
Research & Publications
Biography
News
Research Summary
Dr. Won's research focuses on sex differences in sleep disordered breathing and hypersomnia disorders. She is interested in the social and biological underpinnings of sex differences in the presentation and treatment outcomes of women with obstructive sleep apnea. She is also interested in the different sleep disordered breathing phenotypes affecting men and women.
Coauthors
Research Interests
Sleep Wake Disorders; Women's Health; Sleep Apnea, Obstructive
Selected Publications
- The use of continuous positive airway pressure in COPD-OSA overlap syndrome: A systematic reviewSrivali N, Thongprayoon C, Tangpanithandee S, Cheungpasitporn W, Won C. The use of continuous positive airway pressure in COPD-OSA overlap syndrome: A systematic review Sleep Medicine 2023, 108: 55-60. PMID: 37336060, DOI: 10.1016/j.sleep.2023.05.025.
- International Consensus Statement on Obstructive Sleep ApneaChang JL, Goldberg AN, Alt JA, Mohammed A, Ashbrook L, Auckley D, Ayappa I, Bakhtiar H, Barrera J, Bartley B, Billings M, Boon M, Bosschieter P, Braverman I, Brodie K, Cabrera‐Muffly C, Caesar R, Cahali M, Cai Y, Cao M, Capasso R, Caples S, Chahine L, Chang C, Chang K, Chaudhary N, Cheong C, Chowdhuri S, Cistulli P, Claman D, Collen J, Coughlin K, Creamer J, Davis E, Dupuy‐McCauley K, Durr M, Dutt M, Ali M, Elkassabany N, Epstein L, Fiala J, Freedman N, Gill K, Gillespie M, Golisch L, Gooneratne N, Gottlieb D, Green K, Gulati A, Gurubhagavatula I, Hayward N, Hoff P, Hoffmann O, Holfinger S, Hsia J, Huntley C, Huoh K, Huyett P, Inala S, Ishman S, Jella T, Jobanputra A, Johnson A, Junna M, Kado J, Kaffenberger T, Kapur V, Kezirian E, Khan M, Kirsch D, Kominsky A, Kryger M, Krystal A, Kushida C, Kuzniar T, Lam D, Lettieri C, Lim D, Lin H, Liu S, MacKay S, Magalang U, Malhotra A, Mansukhani M, Maurer J, May A, Mitchell R, Mokhlesi B, Mullins A, Nada E, Naik S, Nokes B, Olson M, Pack A, Pang E, Pang K, Patil S, Van de Perck E, Piccirillo J, Pien G, Piper A, Plawecki A, Quigg M, Ravesloot M, Redline S, Rotenberg B, Ryden A, Sarmiento K, Sbeih F, Schell A, Schmickl C, Schotland H, Schwab R, Seo J, Shah N, Shelgikar A, Shochat I, Soose R, Steele T, Stephens E, Stepnowsky C, Strohl K, Sutherland K, Suurna M, Thaler E, Thapa S, Vanderveken O, Vries N, Weaver E, Weir I, Wolfe L, Woodson B, Won C, Xu J, Yalamanchi P, Yaremchuk K, Yeghiazarians Y, Yu J, Zeidler M, Rosen I. International Consensus Statement on Obstructive Sleep Apnea International Forum Of Allergy & Rhinology 2023, 13: 1061-1482. PMID: 36068685, DOI: 10.1002/alr.23079.
- In-office communication about excessive daytime sleepiness associated with treated obstructive sleep apnea: insights from an ethnographic study of physician-patient visitsWon C, Bogan R, Doghramji K, Ojile J, Bujanover S, Hyman D, Hewett K, Thomas R. In-office communication about excessive daytime sleepiness associated with treated obstructive sleep apnea: insights from an ethnographic study of physician-patient visits Sleep Science And Practice 2022, 6: 4. DOI: 10.1186/s41606-022-00072-y.
- Recent cannabis use and nightly sleep duration in adults: a population analysis of the NHANES from 2005 to 2018.Diep C, Tian C, Vachhani K, Won C, Wijeysundera DN, Clarke H, Singh M, Ladha KS. Recent cannabis use and nightly sleep duration in adults: a population analysis of the NHANES from 2005 to 2018. Regional Anesthesia And Pain Medicine 2022, 47: 100-104. PMID: 34873024, DOI: 10.1136/rapm-2021-103161.
- Severe breakthrough COVID-19 cases in the SARS-CoV-2 delta (B.1.617.2) variant eraWang SY, Juthani PV, Borges KA, Shallow MK, Gupta A, Price C, Won CH, Chun HJ. Severe breakthrough COVID-19 cases in the SARS-CoV-2 delta (B.1.617.2) variant era The Lancet Microbe 2021, 3: e4-e5. PMID: 34901896, PMCID: PMC8641954, DOI: 10.1016/s2666-5247(21)00306-2.
- Amplifying women's voices and representation of women speakers and moderators at the Society of Anesthesia and Sleep Medicine: A retrospective analysis, 2011-2020.Lorello GR, Haider T, Rahman N, Won C, Ramachandran SK, Huszti E, Singh M. Amplifying women's voices and representation of women speakers and moderators at the Society of Anesthesia and Sleep Medicine: A retrospective analysis, 2011-2020. Journal Of Clinical Anesthesia 2021, 75: 110494. PMID: 34464769, DOI: 10.1016/j.jclinane.2021.110494.
- Hospitalisation among vaccine breakthrough COVID-19 infectionsJuthani PV, Gupta A, Borges KA, Price CC, Lee AI, Won CH, Chun HJ. Hospitalisation among vaccine breakthrough COVID-19 infections The Lancet Infectious Diseases 2021, 21: 1485-1486. PMID: 34506735, PMCID: PMC8423430, DOI: 10.1016/s1473-3099(21)00558-2.
- Impact of Sex on Sleep Disorders Across the LifespanTobias L, Thapa S, Won CHJ. Impact of Sex on Sleep Disorders Across the Lifespan Clinics In Chest Medicine 2021, 42: 427-442. PMID: 34353449, DOI: 10.1016/j.ccm.2021.04.005.
- Optimal NIV Medicare Access Promotion: Patients With Hypoventilation Syndromes A Technical Expert Panel Report From the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic SocietyMokhlesi B, Won CH, Make BJ, Selim BJ, Sunwoo BY, Panel O, Gay P, Owens R, Wolfe L, Benditt J, Aboussouan L, Coleman J, Hess D, Hill N, Criner G, Branson R, Celli B, MacIntyre N, Sergew A, Morgenthaler T, Malhotra A, Berry R, Johnson K, Raphaelson M, Mokhlesi B, Won C, Selim B, Make B, Sunwoo B, Collop N, Patil S, Chediak A, Olson E, Vohra K. Optimal NIV Medicare Access Promotion: Patients With Hypoventilation Syndromes A Technical Expert Panel Report From the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society CHEST Journal 2021, 160: e377-e387. PMID: 34339686, PMCID: PMC8628178, DOI: 10.1016/j.chest.2021.06.083.
- The use of telemedicine for the diagnosis and treatment of sleep disorders: an American Academy of Sleep Medicine update.Shamim-Uzzaman QA, Bae CJ, Ehsan Z, Setty AR, Devine M, Dhankikar S, Donskoy I, Fields B, Hearn H, Hwang D, Jain V, Kelley D, Kirsch DB, Martin W, Troester M, Trotti LM, Won CH, Epstein LJ. The use of telemedicine for the diagnosis and treatment of sleep disorders: an American Academy of Sleep Medicine update. Journal Of Clinical Sleep Medicine 2021, 17: 1103-1107. PMID: 33599202, PMCID: PMC8320493, DOI: 10.5664/jcsm.9194.
- Identification of Sleep Medicine and Anesthesia Core Topics for Anesthesia Residency: A Modified Delphi Technique Survey.Berezin L, Nagappa M, Wong J, Clivatti J, Singh M, Auckley D, Charchaflieh JG, Fagerlund M, Jonsson Fagerlund M, Gali B, Joshi GP, Overdyk FJ, Margarson M, Mokhlesi B, Moon T, Ramachandran SK, Ryan CM, Schumann R, Weingarten TN, Won CHJ, Chung F. Identification of Sleep Medicine and Anesthesia Core Topics for Anesthesia Residency: A Modified Delphi Technique Survey. Anesthesia & Analgesia 2021, 132: 1223-1230. PMID: 33857964, DOI: 10.1213/ane.0000000000005446.
- A neutrophil activation signature predicts critical illness and mortality in COVID-19Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun HJ. A neutrophil activation signature predicts critical illness and mortality in COVID-19 Blood Advances 2021, 5: 1164-1177. PMID: 33635335, PMCID: PMC7908851, DOI: 10.1182/bloodadvances.2020003568.
- Circulating markers of angiogenesis and endotheliopathy in COVID‐19Pine AB, Meizlish ML, Goshua G, Chang C, Zhang H, Bishai J, Bahel P, Patel A, Gbyli R, Kwan JM, Won CH, Price C, Dela Cruz CS, Halene S, Dijk D, Hwa J, Lee AI, Chun HJ. Circulating markers of angiogenesis and endotheliopathy in COVID‐19 Pulmonary Circulation 2020, 10: 1-4. PMID: 33282193, PMCID: PMC7691906, DOI: 10.1177/2045894020966547.
- Life Cycle Impact on Sleep in WomenPengo M, Won C, Bourjeily G. Life Cycle Impact on Sleep in Women 2020, 17-37. DOI: 10.1007/978-3-030-40842-8_3.
- Obstructive Sleep Apnea in WomenAyub S, Won C. Obstructive Sleep Apnea in Women Journal Of Sleep Medicine 2019, 16: 75-80. DOI: 10.13078/jsm.190047.
- Sex differences in obstructive sleep apnea phenotypes, the multi-ethnic study of atherosclerosisWon C, Reid M, Sofer T, Azarbarzin A, Purcell S, White D, Wellman A, Sands S, Redline S. Sex differences in obstructive sleep apnea phenotypes, the multi-ethnic study of atherosclerosis Sleep 2019, 43: zsz274. PMID: 31687772, PMCID: PMC7215264, DOI: 10.1093/sleep/zsz274.
- Sex Differences in Apnea-Hypopnea Index: Influence of Definitions and Physiologic MechanismsWon C, Reid M, Sands S, Sofer T, Wellman D, Redline S. Sex Differences in Apnea-Hypopnea Index: Influence of Definitions and Physiologic Mechanisms 2019, a7261-a7261. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7261.
- Assessing Communication Between Physicians and Patients with Excessive Daytime Sleepiness Associated with Treated Obstructive Sleep Apnea: Insights from an Ethnographic Study of In-Office VisitsWon C, Bogan R, Doghramji K, Ojile J, Bujanover S, Hyman D, Hewett K, Thomas R. Assessing Communication Between Physicians and Patients with Excessive Daytime Sleepiness Associated with Treated Obstructive Sleep Apnea: Insights from an Ethnographic Study of In-Office Visits 2019, a1390-a1390. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1390.
- Chapter 6 Lung DiseasesTobias L, Won C. Chapter 6 Lung Diseases 2019, 121-151. DOI: 10.1016/b978-0-12-813014-8.00006-8.
- Varying Hypopnea Definitions Affect Obstructive Sleep Apnea Severity Classification and Association With Cardiovascular Disease.Won CHJ, Qin L, Selim B, Yaggi HK. Varying Hypopnea Definitions Affect Obstructive Sleep Apnea Severity Classification and Association With Cardiovascular Disease. Journal Of Clinical Sleep Medicine 2018, 14: 1987-1994. PMID: 30518445, PMCID: PMC6287733, DOI: 10.5664/jcsm.7520.
- Treating Sleep-Related Breathing DisordersWon C, Mohsenin V, Kryger M. Treating Sleep-Related Breathing Disorders 2018, 105-123. DOI: 10.1007/978-1-4939-8607-1_9.
- Diagnosing and Treating Sleep Apnea in Patients With Acute Cerebrovascular DiseaseBravata DM, Sico J, Fragoso C, Miech EJ, Matthias MS, Lampert R, Williams LS, Concato J, Ivan CS, Fleck JD, Tobias L, Austin C, Ferguson J, Radulescu R, Iannone L, Ofner S, Taylor S, Qin L, Won C, Yaggi HK. Diagnosing and Treating Sleep Apnea in Patients With Acute Cerebrovascular Disease Journal Of The American Heart Association 2018, 7: e008841. PMID: 30369321, PMCID: PMC6201384, DOI: 10.1161/jaha.118.008841.
- Impact of Sleep Breathing Disorders in Obese Critically Ill PatientsAl-Halawani M, Won C. Impact of Sleep Breathing Disorders in Obese Critically Ill Patients 2017, 77-85. DOI: 10.1007/978-3-319-49253-7_8.
- Chapter 131 Fibromyalgia and Chronic Fatigue SyndromesWon C, Kirsch D. Chapter 131 Fibromyalgia and Chronic Fatigue Syndromes 2017, 1294-1299.e4. DOI: 10.1016/b978-0-323-24288-2.00131-8.
- The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study.Selim BJ, Koo BB, Qin L, Jeon S, Won C, Redeker NS, Lampert RJ, Concato JP, Bravata DM, Ferguson J, Strohl K, Bennett A, Zinchuk A, Yaggi HK. The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study. Journal Of Clinical Sleep Medicine 2016, 12: 829-37. PMID: 26951420, PMCID: PMC4877315, DOI: 10.5664/jcsm.5880.
- The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methodsKoo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods Sleep And Breathing 2015, 20: 893-900. PMID: 26642771, DOI: 10.1007/s11325-015-1254-3.
- Gender differences in sleep disordered breathing: implications for therapyWon C, Guilleminault C. Gender differences in sleep disordered breathing: implications for therapy Expert Review Of Respiratory Medicine 2015, 9: 221-231. PMID: 25739831, DOI: 10.1586/17476348.2015.1019478.
- The impact of gender on timeliness of narcolepsy diagnosis.Won C, Mahmoudi M, Qin L, Purvis T, Mathur A, Mohsenin V. The impact of gender on timeliness of narcolepsy diagnosis. Journal Of Clinical Sleep Medicine 2014, 10: 89-95. PMID: 24426826, PMCID: PMC3869076, DOI: 10.5664/jcsm.3370.
- Obesity Hypoventilation Syndrome: An Impending Epidemic.Won, CH. Obesity Hypoventilation Syndrome: An Impending Epidemic. Clinical Pulmonary Medicine. 20(1):36-42, January 2013
- Narcolepsy-Characteristics of those in the Borderland-We Need a Better Diagnostic ToolMahmoudi M, Won C, Mohsenin V. Narcolepsy-Characteristics of those in the Borderland-We Need a Better Diagnostic Tool Journal Of Sleep Disorders Treatment & Care 2013, 02 DOI: 10.4172/2325-9639.1000106.
- Implications of OSA on Work and Work Disability Including Drivers.Teng AY, Won C. Implications of OSA on Work and Work Disability Including Drivers. Clinics In Chest Medicine 2012, 33: 731-44. PMID: 23153612, DOI: 10.1016/j.ccm.2012.09.003.
- Severe obstructive sleep apnea increases mortality in patients with ischemic heart disease and myocardial injuryWon CH, Chun HJ, Chandra SM, Sarinas PS, Chitkara RK, Heidenreich PA. Severe obstructive sleep apnea increases mortality in patients with ischemic heart disease and myocardial injury Sleep And Breathing 2012, 17: 85-91. PMID: 22294346, DOI: 10.1007/s11325-012-0653-y.
- An Overlap Phenomenon Exists With Interstitial Lung Disease And Obstructive Sleep ApneaWon C, Purvis T, Bennett A, Chun H. An Overlap Phenomenon Exists With Interstitial Lung Disease And Obstructive Sleep Apnea 2011, a5272-a5272. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5272.
- Epidemiology of sleep-related complaints associated with sleep-disordered breathing in Bangkok, ThailandSuwanprathes P, Won C, Komoltri C, Nana A, Kotchabhakdi N, Guilleminault C. Epidemiology of sleep-related complaints associated with sleep-disordered breathing in Bangkok, Thailand Sleep Medicine 2010, 11: 1025-1030. PMID: 20643577, DOI: 10.1016/j.sleep.2010.04.007.
- Cardiovascular Consequences of Sleep ApneaSelim B, Won C, Yaggi HK. Cardiovascular Consequences of Sleep Apnea Clinics In Chest Medicine 2010, 31: 203-220. PMID: 20488282, DOI: 10.1016/j.ccm.2010.02.010.
- Obstructive Sleep ApneaWon C, Kim J, Guilleminault C. Obstructive Sleep Apnea 2009, 563-565. DOI: 10.1002/9781444317008.ch145.
- Surgical Treatment of Obstructive Sleep ApneaWon CH, Li KK, Guilleminault C. Surgical Treatment of Obstructive Sleep Apnea Annals Of The American Thoracic Society 2008, 5: 193-199. PMID: 18250212, DOI: 10.1513/pats.200708-121mg.
- Pulmonary artery catheter effectiveness in congestive heart failure.Won C, Kuschner WG. Pulmonary artery catheter effectiveness in congestive heart failure. JAMA 2006, 295: 1121; author reply 1121-2. PMID: 16522827, DOI: 10.1001/jama.295.10.1121-a.
- Intracranial hypertension caused by obstructive sleep apnea and obesity hypoventilation syndrome.Won CH, Kirsch C. Intracranial hypertension caused by obstructive sleep apnea and obesity hypoventilation syndrome. Chest. 2006;130(4)345-6.