Matthew Rodeheffer, PhD
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Cards
Appointments
Comparative Medicine
Primary
Cellular & Molecular Physiology
Secondary
Contact Info
Comparative Medicine
PO Box 208016
New Haven, CT 06520-8016
United States
About
Titles
Associate Professor of Comparative Medicine
Appointments
Comparative Medicine
Associate Professor TenurePrimaryCellular & Molecular Physiology
ProfessorSecondary
Other Departments & Organizations
- Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS)
- Cancer Signaling Networks
- Cellular & Molecular Physiology
- Comparative Medicine
- Diabetes Research Center
- Discovery to Cure Internship
- Molecular Medicine, Pharmacology, and Physiology
- Obesity Research Working Group
- Rodeheffer Lab
- WHRY Pilot Project Program Investigators
- Women's Health Research at Yale
- Yale Cancer Center
- Yale Center for Molecular and Systems Metabolism (YMSM)
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Fibrosis Program
- Yale Stem Cell Center
- Yale Ventures
Education & Training
- Postdoctoral Fellow
- HHMI, Rockefeller University (2008)
- PhD
- Emory University (2002)
- BS
- University of Washington (Seattle) (1997)
Research
Overview
Obesity, which is defined as an excessive increase in white adipose tissue (fat) mass, is one of the leading public health concerns of the 21st century. The relevance of obesity as a public health concern is due to two main factors 1) the rates of obesity have increased over the last thirty years and today almost one third of the adult population in the U.S. is classified as obese, and 2) obesity is associated with several other health conditions, including type 2 diabetes, cardiovascular disease and some forms of cancer.
Despite the importance of fat in human disease our understanding of the regulation of fat mass is limited. The research in my laboratory is directed toward elucidating the molecular mechanisms that regulate fat mass and contribute to the development of obesity and obesity associated pathologies. Specifically, we focus on identifying and characterizing fat progenitor and stem cells and the molecular processes that control the differentiation of these cells into mature, lipid-filled fat cells.
We take several approaches to accomplish our research goals, employing several mouse models of human disease, human primary cell culture, genomic and proteomic techniques and developing novel mouse models for the study of fat regulation. Determining how the growth of fat is regulated may lead to the development of novel therapeutics for the treatment of obesity, diabetes and cardiovascular disease.
Despite the importance of fat in human disease our understanding of the regulation of fat mass is limited. The research in my laboratory is directed toward elucidating the molecular mechanisms that regulate fat mass and contribute to the development of obesity and obesity associated pathologies. Specifically, we focus on identifying and characterizing fat progenitor and stem cells and the molecular processes that control the differentiation of these cells into mature, lipid-filled fat cells.
We take several approaches to accomplish our research goals, employing several mouse models of human disease, human primary cell culture, genomic and proteomic techniques and developing novel mouse models for the study of fat regulation. Determining how the growth of fat is regulated may lead to the development of novel therapeutics for the treatment of obesity, diabetes and cardiovascular disease.
Medical Subject Headings (MeSH)
Genomics; Metabolic Diseases; Overnutrition; Stem Cells
Research at a Glance
Yale Co-Authors
Frequent collaborators of Matthew Rodeheffer's published research.
Publications Timeline
A big-picture view of Matthew Rodeheffer's research output by year.
Research Interests
Research topics Matthew Rodeheffer is interested in exploring.
Jackie A. Fretz, PhD
Valerie Horsley, PhD
13Publications
2,749Citations
Stem Cells
Publications
2019
Identification of metabolically distinct adipocyte progenitor cells in human adipose tissues
A R, G O, J B, PE O, RB S, AK C, RA T, MS R, PR B, MJ W. Identification of metabolically distinct adipocyte progenitor cells in human adipose tissues. 2019 DOI: 10.1530/ey.16.11.11.Peer-Reviewed Original ResearchIdentification and characterisation of metabolically distinct human adipocyte precursor cells
Raajendiran A, Ooi G, Clark A, Bayliss J, O’Brien P, Taylor R, Rodeheffer M, Burton P, Watt M. Identification and characterisation of metabolically distinct human adipocyte precursor cells. Obesity Research & Clinical Practice 2019, 13: 263. DOI: 10.1016/j.orcp.2018.11.080.Peer-Reviewed Original Research
2016
The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity
Jeffery E, Wing A, Holtrup B, Sebo Z, Kaplan JL, Saavedra-Peña R, Church CD, Colman L, Berry R, Rodeheffer MS. The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity. Cell Metabolism 2016, 24: 142-150. PMID: 27320063, PMCID: PMC4945385, DOI: 10.1016/j.cmet.2016.05.012.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVisceral white adipose tissueHigh-fat dietAdipose tissueAdipocyte precursorsAdipocyte hyperplasiaDepot-specific adipogenesisDifferential fat distributionObesity-associated pathologiesWhite adipose tissueAdipose tissue microenvironmentSubcutaneous adipose tissueAdipose tissue growthCell-intrinsic mechanismsMetabolic healthFat distributionMale miceHormone-dependent mannerDimorphic distributionObesityHyperplasiaAdipogenesisTissue microenvironmentTissueMicroenvironmentPlastic cellsFat Decisions: Leptin Regulates Bone versus Fat in the Marrow
Rodeheffer MS, Horowitz MC. Fat Decisions: Leptin Regulates Bone versus Fat in the Marrow. Cell Stem Cell 2016, 18: 684-686. PMID: 27257753, DOI: 10.1016/j.stem.2016.05.006.Peer-Reviewed Original ResearchCitationsAltmetricChapter 20 Marrow Adipose Tissue and its Interactions with the Skeletal, Hematopoietic, and Immune Systems
Berry R, Fretz J, MacDougald O, Klibansky A, Rosen C, Rodeheffer M, Horowitz M. Chapter 20 Marrow Adipose Tissue and its Interactions with the Skeletal, Hematopoietic, and Immune Systems. 2016, 345-352. DOI: 10.1016/b978-0-12-800571-2.00020-7.Peer-Reviewed Original Research
2015
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity
Jeffery E, Church CD, Holtrup B, Colman L, Rodeheffer MS. Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity. Nature Cell Biology 2015, 17: 376-385. PMID: 25730471, PMCID: PMC4380653, DOI: 10.1038/ncb3122.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdipocytes, WhiteAdipogenesisAdipose Tissue, WhiteAndrostadienesAnimalsCell ProliferationDiet, High-FatEatingMaleMiceMice, Inbred C57BLMice, KnockoutObesityPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsProto-Oncogene Proteins c-aktRandom AllocationTamoxifenWortmanninConceptsWhite adipose tissueAdipocyte precursorsMolecular mechanismsWAT growthNew adipocytesHigh-fat diet feedingCharacteristics of obesityOnset of obesityDistinct molecular mechanismsActivation of adipogenesisAdipocyte precursor cellsWAT massVisceral depotsDiet feedingMale miceAdipose tissueObesityAkt2 pathwayMature adipocytesPrecursor cellsAdipogenesisAdipocytesExcessive accumulationMiceActivation
2013
Weighing in on Adipocyte Precursors
Berry R, Jeffery E, Rodeheffer MS. Weighing in on Adipocyte Precursors. Cell Metabolism 2013, 19: 8-20. PMID: 24239569, PMCID: PMC3947170, DOI: 10.1016/j.cmet.2013.10.003.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsCharacterization of the adipocyte cellular lineage in vivo
Berry R, Rodeheffer MS. Characterization of the adipocyte cellular lineage in vivo. Nature Cell Biology 2013, 15: 302-308. PMID: 23434825, PMCID: PMC3721064, DOI: 10.1038/ncb2696.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdipocytes, WhiteAdipogenesisAnimalsAntigens, CDBlotting, WesternCadherinsCell DifferentiationCell LineageCell ProliferationEndothelium, VascularFlow CytometryHematopoietic Stem CellsMaleMiceMice, Inbred C57BLMice, TransgenicReal-Time Polymerase Chain ReactionReceptor, Platelet-Derived Growth Factor alphaReverse Transcriptase Polymerase Chain ReactionRNA, Messenger
2011
Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis.
Birsoy K, Berry R, Wang T, Ceyhan O, Tavazoie S, Friedman J, Rodeheffer M. Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis. Journal Of Cell Science 2011, 124: e1-e1. DOI: 10.1242/jcs.101436.Peer-Reviewed Original ResearchCitationsAnalysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis
Birsoy K, Berry R, Wang T, Ceyhan O, Tavazoie S, Friedman JM, Rodeheffer MS. Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis. Development 2011, 138: 4709-4719. PMID: 21989915, PMCID: PMC3190384, DOI: 10.1242/dev.067710.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH Keywords3T3-L1 CellsAdipogenesisAdipose Tissue, WhiteAnimalsGene Expression Regulation, DevelopmentalGene Knockdown TechniquesGene Regulatory NetworksHumansMaleMiceMice, Inbred C57BLMice, TransgenicMicroarray AnalysisNF-E2-Related Factor 2Promoter Regions, GeneticProto-Oncogene Protein c-ets-1Proto-Oncogene Protein c-ets-2ConceptsTranscription factorsWhite adipose tissue developmentGene networksAdipose tissue developmentGene expressionTissue developmentETS transcription factorsEarly gene clusterDistinct transcriptional programsWAT developmentAdipocyte differentiation programImportant transcription factorFormation of adipocytesMotif discovery toolsGene clusterEarly adipogenesisTranscriptional programsDifferentiation programBAC transgenic miceDNA microarraysDevelopmental transitionsMolecular mechanismsMolecular characterizationSignificant enrichmentEts2
Academic Achievements and Community Involvement
honor Helmholtz Young Investigator in Diabetes
International AwardHelmholtz Diabetes Institute-NovonordiskDetails09/26/2015Germanyhonor Junior Faculty Award
National AwardAmerican Diabetes AssociationDetails07/01/2012United States
Links & Media
News
- September 27, 2017
Battling belly fat: Specialized immune cells impair metabolism in aging
- October 17, 2016
Yale Researchers Tackle Cannabis Use and Obesity in WHRY-Funded Studies
- October 17, 2016Source: Women's Health Research at Yale
Yale Researchers Tackle Cannabis Use and Obesity in WHRY-Funded Studies
- June 16, 2016
Women may face a double weight-gain whammy
Get In Touch
Contacts
Mailing Address
Comparative Medicine
PO Box 208016
New Haven, CT 06520-8016
United States