Joseph Santos-Sacchi, PhD
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Cards
Appointments
Otolaryngology Surgery
Primary
Cellular & Molecular Physiology
Secondary
Contact Info
Otolaryngology Surgery
PO Box 208062
New Haven, CT 06520-8062
United States
About
Titles
Professor of Surgery (Otolaryngology), of Cellular and Molecular Physiology and of Neuroscience
Biography
Dr. Joseph Santos-Sacchi, Professor, works on understanding how outer hair cells (OHC) help us hear so well. His lab focuses on electrophysiological assessment of hair cell function and molecular manipulations of the proteins that are important for hearing.
Appointments
Otolaryngology Surgery
ProfessorPrimaryCellular & Molecular Physiology
ProfessorSecondaryNeuroscience
ProfessorSecondary
Other Departments & Organizations
Education & Training
- MPhil
- Columbia University, Audiology (1978)
- PhD
- Columbia University (1978)
- BA
- Columbia College, Psychology (1973)
Research
Overview
Medical Subject Headings (MeSH)
Ear, Inner; Hair Cells, Auditory; Neurosciences; Otolaryngology; Physiology
Research at a Glance
Yale Co-Authors
Frequent collaborators of Joseph Santos-Sacchi's published research.
Publications Timeline
A big-picture view of Joseph Santos-Sacchi's research output by year.
Research Interests
Research topics Joseph Santos-Sacchi is interested in exploring.
Lei Song, MD, PhD
Dhasakumar Navaratnam, MD, PhD
Shumin Bian
Hong-Bo Zhao, MD, PhD
Jun-Ping Bai, PhD
Michael Paidas, MD
152Publications
6,089Citations
Hair Cells, Auditory
Ear, Inner
Publications
2023
The biology of hearing and hearing loss: New insights from naked mole-rats into mechanisms and adaptive responses
Pyott S, Jagersma J, van Tuinen M, Koch U, Lauer A, Park T, Lysakowski A, Santos-Sacchi J, Kumar S, Ryugo D. The biology of hearing and hearing loss: New insights from naked mole-rats into mechanisms and adaptive responses. The Journal Of The Acoustical Society Of America 2023, 154: a298-a299. DOI: 10.1121/10.0023589.Peer-Reviewed Original ResearchConceptsBiology of hearingBundle proteinHair bundle proteinAdaptive responseAmino acid substitutionsEusocial lifestyleEvolutionary legacySubterranean speciesPositive selectionComparative organizationAcid substitutionsHair bundlesCochlear amplificationBiologySpeciesProteinNew insightsHearing lossPoor hearingComparative approachDisease modelsMechanistic approachCentral auditory structuresCentral compensationRats resultsPharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative Stress
Tan W, Santos-Sacchi J, Tonello J, Shanker A, Ivanova A. Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative Stress. Antioxidants 2023, 12: 1225. PMID: 37371955, PMCID: PMC10294946, DOI: 10.3390/antiox12061225.Peer-Reviewed Original ResearchCitationsConceptsPharmacological modulationKO miceMitochondrial metabolismComparative gene expression analysisMetabolic pathwaysOxidative stressCritical biological processesHearing-related genesDrug-specific responsesPremature hearing lossGene expression analysisAdrenal axisHearing lossImmune responseMitochondrial morphologyMotor proteinsExpression analysisVoltage-gated channelsBiological processesMTOR pathwayNormal hearingPronounced upregulationMolecular pathwaysMitochondrial activityEnergy sensingMegahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification
Santos-Sacchi J, Bai J, Navaratnam D. Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification. Journal Of Neuroscience 2023, 43: 2460-2468. PMID: 36868859, PMCID: PMC10082455, DOI: 10.1523/jneurosci.2033-22.2023.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsConformational switchingMammalian hearingMembrane motor proteinCochlear amplificationMotor protein prestinVoltage-sensor charge movementOuter hair cell electromotilityHair cell electromotilityProtein prestinMotor proteinsConformation switchingCharge movementPrestinPrestin activityCell membraneOHC electromotilityHair cell membraneElectromotilityTransmembrane voltageOrgan of CortiAmplificationMammalsMembrane capacitanceProtein
2022
Outer hair cell function is normal in βV spectrin knockout mice
Stankewich MC, Bai JP, Stabach PR, Khan S, Tan WJT, Surguchev A, Song L, Morrow JS, Santos-Sacchi J, Navaratnam DS. Outer hair cell function is normal in βV spectrin knockout mice. Hearing Research 2022, 423: 108564. PMID: 35864018, DOI: 10.1016/j.heares.2022.108564.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsOuter hair cellsAuditory brainstem response wavesAuditory thresholdOuter hair cell functionSpiral ganglion neuronsEfferent nerve fibersHair cell functionNumber of afferentsGanglion neuronsNerve fibersKnockout miceNeuronal structuresMiceHair cellsCell functionElectromechanical activityPutative roleType IOngoing investigationExon deletionsSynaptopathyAfferentsData supportResponse wavesNeuronsOn the frequency response of prestin charge movement in membrane patches
Santos-Sacchi J, Tan W. On the frequency response of prestin charge movement in membrane patches. Biophysical Journal 2022, 121: 2371-2379. PMID: 35598044, PMCID: PMC9279172, DOI: 10.1016/j.bpj.2022.05.020.Peer-Reviewed Original ResearchCitationsPhysiology and biophysics of outer hair cells: The cells of Dallos
Santos-Sacchi J, Navaratnam D. Physiology and biophysics of outer hair cells: The cells of Dallos. Hearing Research 2022, 423: 108525. PMID: 35599199, DOI: 10.1016/j.heares.2022.108525.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsSingle particle cryo-EM structure of the outer hair cell motor protein prestin
Butan C, Song Q, Bai JP, Tan WJT, Navaratnam D, Santos-Sacchi J. Single particle cryo-EM structure of the outer hair cell motor protein prestin. Nature Communications 2022, 13: 290. PMID: 35022426, PMCID: PMC8755724, DOI: 10.1038/s41467-021-27915-z.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTransmembrane domainProtein prestinSingle-particle cryo-EM structuresAnti-sigma factor antagonist domainOuter hair cell motor protein prestinCryo-EM structureCryo-electron microscopyMotor protein prestinSLC26 family membersSulfate transportersTransmembrane segmentsPrestin functionÅ resolutionPrestinOHC electromotilityOpen stateCochlear amplificationPutative mechanismsFamily membersDomainRepeatsSLC26A9TransportersMutationsElectromotility
2021
Coupling between outer hair cell electromotility and prestin sensor charge depends on voltage operating point
Santos-Sacchi J, Tan WJT. Coupling between outer hair cell electromotility and prestin sensor charge depends on voltage operating point. Hearing Research 2021, 423: 108373. PMID: 34776274, PMCID: PMC9054947, DOI: 10.1016/j.heares.2021.108373.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsOperating voltage rangeFrequency responseAC voltage excitationSlow frequency responseVoltage operating pointNonlinear capacitanceOperating voltageOperating pointVoltage excitationVoltage rangeSpecial Issue Outer hair cellJoseph Santos-SacchiVoltageKumar NavaratnamLoadVoltage-sensor charge movementGenes related to SNPs identified by Genome-wide association studies of age-related hearing loss show restriction to specific cell types in the adult mouse cochlea
Xue N, Song L, Song Q, Santos-Sacchi J, Wu H, Navaratnam D. Genes related to SNPs identified by Genome-wide association studies of age-related hearing loss show restriction to specific cell types in the adult mouse cochlea. Hearing Research 2021, 410: 108347. PMID: 34536825, DOI: 10.1016/j.heares.2021.108347.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSingle-cell RNA sequencingApical cell polarityGenome-wide association studiesAdult mouse cochleaSpecific cell typesCell polaritySubtypes of cellsSignificant genetic componentSingle nucleotide polymorphismsVesicle recyclingRNA sequencingAssociation studiesGenesVarying ExpressionCell typesGenetic componentNucleotide polymorphismsSNPsMouse cochleaCell functionGenesetsHair cellsHair cell functionSignificant overlapExpressionThe naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole‐rat biology
Buffenstein R, Amoroso V, Andziak B, Avdieiev S, Azpurua J, Barker AJ, Bennett NC, Brieño‐Enríquez M, Bronner GN, Coen C, Delaney MA, Dengler‐Crish C, Edrey YH, Faulkes CG, Frankel D, Friedlander G, Gibney PA, Gorbunova V, Hine C, Holmes MM, Jarvis JUM, Kawamura Y, Kutsukake N, Kenyon C, Khaled WT, Kikusui T, Kissil J, Lagestee S, Larson J, Lauer A, Lavrenchenko LA, Lee A, Levitt JB, Lewin GR, Hardell K, Lin TD, Mason MJ, McCloskey D, McMahon M, Miura K, Mogi K, Narayan V, O'Connor TP, Okanoya K, O'Riain MJ, Park TJ, Place NJ, Podshivalova K, Pamenter ME, Pyott SJ, Reznick J, Ruby JG, Salmon AB, Santos‐Sacchi J, Sarko DK, Seluanov A, Shepard A, Smith M, Storey KB, Tian X, Vice EN, Viltard M, Watarai A, Wywial E, Yamakawa M, Zemlemerova ED, Zions M, St. John Smith E. The naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole‐rat biology. Biological Reviews 2021, 97: 115-140. PMID: 34476892, PMCID: PMC9277573, DOI: 10.1111/brv.12791.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements and Community Involvement
honor Master of Arts, Honoris Cuasa
UnknownYale University, New Haven, CTDetails01/01/1995United States
Links & Media
News
- January 19, 2024Source: Yale Daily News
Yale scientists look to hearing loss to detect Alzheimer’s early
- January 08, 2024
Noisier and More Forgetful? Yale Scientist Explores Auditory Underpinnings of Dementia
- February 20, 2019
Dean’s Workshop on March 12: "Yale Center for Cellular and Molecular Imaging (CCMI): Innovations in Visualization and Optical Imaging of Fixed and Living Cells and Tissues"
- February 06, 2017
Antioxidants and hearing loss
Get In Touch
Contacts
Academic Office Number
Mailing Address
Otolaryngology Surgery
PO Box 208062
New Haven, CT 06520-8062
United States
Locations
Brady Memorial Laboratory
Academic Office
310 Cedar Street, Ste Room 224
New Haven, CT 06510