Demetrios Braddock, MD, PhD
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About
Titles
Associate Professor of Pathology
Biography
Demetrios Braddock was born in Tennessee, educated at the University of Chicago, trained at the NIH in Anatomic Pathology and Biophysical Chemistry, and came to Yale in 2004 where he practices hematopathology and heads a laboratory studying pathogenic mechanisms of severe and poorly addressed human diseases. His laboratory focuses on rare diseases of children, and on the design and engineering of novel biologics to modulate disease outcomes.
Work in Dr. Braddock’s laboratory includes the design and validation of an enzyme biologic for a lethal infantile calcification disorder called ‘Generalized Arterial Calcification of Infancy’ (GACI), which has been translated into patients and is now in clinical trials in infants, children, and adults with GACI, ARHR2, PXE, and CKD-MBD (ClinicalTrials.gov: NCT05734196, NCT06046820, NCT04686175, NCT06283589).
Appointments
Pathology
Associate Professor on TermPrimary
Other Departments & Organizations
- Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS)
- Braddock Lab
- Dean's Workshops
- Discovery to Cure Internship
- Genomics, Genetics, and Epigenetics
- Hematopathology
- Hematopathology
- Molecular Medicine, Pharmacology, and Physiology
- Pathology
- Pathology and Molecular Medicine
- Pathology Research
- Program in Translational Biomedicine (PTB)
- Prostate & Urologic Cancers Program
- Structural Biology
- Surgical Pathology
- Vascular Biology and Therapeutics Program
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine
- Yale Ventures
Education & Training
- Fellow
- Yale University School of Medicine (2010)
- Resident
- National Cancer Institute, NIH, Laboratory of Pathology (2000)
- MD
- University of Chicago Pritzker School of Medicine (1996)
- PhD
- University of Chicago (1994)
Research
Academic Achievements and Community Involvement
Clinical Care
Overview
Demetrios Braddock, MD, PhD, is a pathologist who specializes in diagnosing blood cancers and diseases, especially a rare disease called generalized arterial calcification of infancy (GACI). As an undergraduate student, Dr. Braddock discovered that he enjoyed the creativity of research, in addition to possibility of helping patients. He decided to pursue a PhD during his medical training. “I enjoy working at the interface of what we know and don’t know, and expanding that border to advance medicine,” he says.
Since coming to Yale, Dr. Braddock has led research in his laboratory on a particular molecule called the ENPP enzyme. Enzymes, produced by cells in the body, serve as catalysts for different biological functions. The family of ENPP enzymes in particular help with blood vessel development and bone mineralization. Patients suffering from GACI usually have calcium deposits built up within their blood vessels, which interfere with blood flow. Dr. Braddock has developed biologic drugs that serve as enzyme replacement therapies to address rare diseases. “I will get phone calls from physicians all over who want more information about diagnosing GACI and who want to learn more about it,” he says.
For him, patient care is one of the most significant motivators in his research lab and in the clinic, when he is examining a patient sample for evidence of disease. “The physician cannot begin treatment of a patient without the correct diagnosis,” he says. “That’s where we come in and try to get the accurate clinical diagnosis for what we see microscopically.”
At Yale School of Medicine, Dr. Braddock is an associate professor of pathology.
Clinical Specialties
Board Certifications
Hematology (Pathology)
- Certification Organization
- AB of Pathology
- Original Certification Date
- 2012
Anatomic Pathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 2000
Links & Media
Media
News
- July 11, 2024Source: Yale Ventures
11 Yale Projects Receive Awards from the Colton Center for Autoimmunity
- June 20, 2024Source: Yale News
New Enzyme Developed at Yale Offers Hope for Patients With Lupus
- April 17, 2024
Demetrios Braddock, MD, PhD, Named Recipient of 2024 Harrington Discovery Institute Scholar-Innovator Award
- March 25, 2024
Yale Pathology Research in Progress: ‘A Rite of Passage’
Get In Touch
Contacts
Locations
Department of Pathology
Academic Office