Simon Milette, PhD
he/him/his
Postdoctoral AssociateDownloadHi-Res Photo
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Yale School of Medicine
300 George Street
New Haven, Connecticut 06511
United States
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Dermatology
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Postdoctoral Associate
Biography
Simon Milette is a Postdoctoral Associate at Yale School of Medicine and Yale Cancer Center in the laboratory of Dr. Goran Mićević. In collaboration with Drs. Richard A. Flavell's and Marcus W. Bosenberg's groups, Dr. Milette's research focuses on resolving T cell epigenetic states in solid tumors, with the long-term goal to overcome therapeutic resistance and engineer durable responses to cancer immunotherapies.
Last Updated on August 11, 2026.
Appointments
Education & Training
- PhD
- McGill University, Experimental Medicine (2024)
- MSc
- McGill University, Experimental Medicine (2018)
- BSc (Hon)
- McGill University, Immunology (2016)
Research
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Overview
Medical Research Interests
Epigenomics; Immunotherapy; Melanoma; Retroelements
Public Health Interests
Bioinformatics; Cancer; Genetics, Genomics, Epigenetics; Immunology; Infectious Diseases
ORCID
0000-0003-2977-0829- View Lab Website
Micevic Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Simon Milette's published research.
Research Interests
Research topics Simon Milette is interested in exploring.
Goran Mićević, MD, PhD
Marcus Bosenberg, MD, PhD
Maya G Deshmukh
Caroline Helen Johnson, PhD
Hong Yan
Former YSMKelly Olino, MD, FACS
Immunotherapy
Melanoma
Publications
2025
Lipophilic statins deplete GPX4 to promote ferroptosis and sensitize cancer cells to immune checkpoint blockade
Talty R, Brooks V, McGeary M, Milette S, Zheng S, Flem-Karlsen K, Daniels A, Deshmukh M, Park K, Caraccio W, Yan H, Echeandia-Francis C, McNamara M, Hong S, Kirwin D, Olino K, Johnson C, Bosenberg M, Micevic G, Roy S. Lipophilic statins deplete GPX4 to promote ferroptosis and sensitize cancer cells to immune checkpoint blockade. Molecular Cancer Therapeutics 2025, 25: 759-770. PMID: 41423587, PMCID: PMC12752129, DOI: 10.1158/1535-7163.mct-25-0667.Peer-Reviewed Original ResearchCitationsAltmetricConceptslipophilic statinsCD8+ T cell infiltrationcell deathpatient-derived melanoma cell linesanticancer effectsanticancer effects of statinsimmune checkpoint blockadetherapeutic potentialT cell infiltrationeffects of statinsmelanoma cell linesfeatures of ferroptosischeckpoint blockadeantitumor immunitytumor clearanceoverall survivalstatin usecolorectal cancerstatin-induced cell deathstatinscancer typessimvastatincell linesmelanomaferroptosisDNA methylation in melanoma immunotherapy: mechanisms and therapeutic opportunities
Deshmukh M, Brooks V, Roy S, Milette S, Bosenberg M, Micevic G. DNA methylation in melanoma immunotherapy: mechanisms and therapeutic opportunities. Clinical Epigenetics 2025, 17: 71. PMID: 40307913, PMCID: PMC12044936, DOI: 10.1186/s13148-025-01865-5.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsanti-tumor immune responseimmune checkpoint moleculesT-cell phenotypederegulated expression of oncogenesexpression of MHCDNA methylationcell-intrinsic rolesilencing tumor suppressor genestumor suppressor geneexpression of oncogenescheckpoint moleculesimmunological therapiesmelanoma immunotherapycell immunogenicityabnormal DNA methylationtumor microenvironmentimmune cellsimproved therapiesmelanomaimmune responsemethylation-based biomarkerstherapeutic opportunitiesderegulated expressionproliferative signalstumor migration
2024
Exploring the prognostic significance of arm-level copy number alterations in triple-negative breast cancer
Doré S, Ali M, Sorin M, McDowell S, Desharnais L, Breton V, Yu M, Arabzadeh A, Ryan M, Milette S, Quail D, Walsh L. Exploring the prognostic significance of arm-level copy number alterations in triple-negative breast cancer. Oncogene 2024, 43: 2015-2024. PMID: 38744952, PMCID: PMC11196216, DOI: 10.1038/s41388-024-03051-y.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptstriple-negative breast cancersomatic copy number alterationsoverall survivalbreast cancerCD8+ T cell infiltrationfocal somatic copy number alterationstriple-negative breast cancer patientstriple-negative breast cancer metastasistriple-negative breast cancer cellsT cell infiltrationcopy number alterationspoor overall survivalbreast cancer progressionbreast cancer cellsTNBC modelsmetastatic lesionstumor burdenCD4+prognostic significancetargeted therapyaggressive subtypetherapeutic resistanceCotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer.
Zhu X, Fu Z, Dutchak K, Arabzadeh A, Milette S, Steinberger J, Morin G, Monast A, Pilon V, Kong T, Adams B, Prando Munhoz E, Hosein H, Fang T, Su J, Xue Y, Rayes R, Sangwan V, Walsh L, Chen G, Quail D, Spicer J, Park M, Dankort D, Huang S. Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer. Cancer Research 2024, 84: 1333-1351. PMID: 38277141, DOI: 10.1158/0008-5472.can-23-1749.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsnon-small cell lung cancersenescent cancer cellsbromodomain-containing protein 4cancer cellsferroptotic cell deathCDK4/6 inhibitorsclinical efficacyKRAS-mutant non-small cell lung cancerKRAS-mutant NSCLC cellscyclin-dependent kinase 4/6CDK4/6 inhibitor palbociclibcell lung cancerreactive oxygen speciesnon-small cell lung cancer cellsbreast cancer treatmentbreast cancer cellscell deathinhibition of Bromodomain-containing protein 4tumor regressioninhibitor palbociclibcell cycle arresttherapeutic vulnerabilities
2023
Obesity alters monocyte developmental trajectories to enhance metastasis
McDowell S, Milette S, Doré S, Yu M, Sorin M, Wilson L, Desharnais L, Cristea A, Varol O, Atallah A, Swaby A, Breton V, Arabzadeh A, Petrecca S, Loucif H, Bhagrath A, De Meo M, Lach K, Issac M, Fiset B, Rayes R, Mandl J, Fritz J, Fiset P, Holt P, Dannenberg A, Spicer J, Walsh L, Quail D. Obesity alters monocyte developmental trajectories to enhance metastasis. Journal Of Experimental Medicine 2023, 220: e20220509. PMID: 37166450, PMCID: PMC10182775, DOI: 10.1084/jem.20220509.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptslung metastasesprofessional antigen-presenting cellsbreast cancer lung metastasisneutrophil activationrelease of neutrophil extracellular trapsobese cancer patientsantigen-presenting cellsmetastasis to lungchronic systemic inflammationneutrophil extracellular trapsperipheral bloodmyeloid lineagemyeloid cellssystemic inflammationlymphoid cellsMHCII expressioncancer patientsmetastasisextracellular trapsflow cytometrycancer metastasismass cytometrySingle-cell spatial landscapes of the lung tumour immune microenvironment
Sorin M, Rezanejad M, Karimi E, Fiset B, Desharnais L, Perus L, Milette S, Yu M, Maritan S, Doré S, Pichette É, Enlow W, Gagné A, Wei Y, Orain M, Manem V, Rayes R, Siegel P, Camilleri-Broët S, Fiset P, Desmeules P, Spicer J, Quail D, Joubert P, Walsh L. Single-cell spatial landscapes of the lung tumour immune microenvironment. Nature 2023, 614: 548-554. PMID: 36725934, PMCID: PMC9931585, DOI: 10.1038/s41586-022-05672-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptstumor immune microenvironmentimmune microenvironmentimmunological landscapesurgical resectiontumor subtypesImaging Mass Cytometryimmune lineagesnon-smallhistological patternclinical correlatesclinical managementlung adenocarcinomaclinical strategiesstratified subgroupscancer progressionmass cytometrytumormicroenvironmental featuresclinical practicecancer research communitytumor corepatientslungsingle-cell technologiesmicroenvironment
2021
A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes’ interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19
Ding J, Hostallero D, Khili M, Fonseca G, Milette S, Noorah N, Guay-Belzile M, Spicer J, Daneshtalab N, Sirois M, Tremblay K, Emad A, Rousseau S. A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes’ interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19. PLOS Computational Biology 2021, 17: e1008810. PMID: 33684134, PMCID: PMC7971900, DOI: 10.1371/journal.pcbi.1008810.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAlgorithmsCell DegranulationComputational BiologyCOVID-19Extracellular TrapsGene Expression RegulationGene Regulatory NetworksGenetic Predisposition to DiseaseHumansLymphohistiocytosis, HemophagocyticModels, BiologicalPandemicsProtein Interaction MapsPulmonary EmbolismSARS-CoV-2ThrombosisViral ProteinsConceptsneutrophil extracellular trapsrelease of NETscomplications of COVID-19abnormal coagulationsevere COVID-19hemophagocytic lymphohistiocytosisthrombotic complicationsvascular thrombosisSARS-CoV-2increased riskextracellular trapsrisk of thrombosisSeverely Ill Patientspulmonary thromboembolisminfluenza epidemics
2020
Neutrophil DNA Webs Untangled
Milette S, Quail D, Spicer J. Neutrophil DNA Webs Untangled. Cancer Cell 2020, 38: 164-166. PMID: 32781042, DOI: 10.1016/j.ccell.2020.07.002.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2019
Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases
Milette S, Hashimoto M, Perrino S, Qi S, Chen M, Ham B, Wang N, Istomine R, Lowy A, Piccirillo C, Brodt P. Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases. Nature Communications 2019, 10: 5745. PMID: 31848339, PMCID: PMC6917725, DOI: 10.1038/s41467-019-13571-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsCell Line, TumorColonic NeoplasmsDisease Models, AnimalEstradiolEstrogen AntagonistsEstrogensFemaleHumansLiverLiver NeoplasmsLung NeoplasmsLymphocytes, Tumor-InfiltratingMaleMiceMice, Inbred C57BLMice, KnockoutMyeloid-Derived Suppressor CellsOvariectomyPancreatic NeoplasmsReceptors, Tumor Necrosis Factor, Type IISex FactorsT-Lymphocytes, RegulatoryTamoxifenTumor MicroenvironmentConceptsmyeloid-derived suppressor cellstumor immune microenvironmentliver metastasesimmune microenvironmentT cellsaccumulation of myeloid-derived suppressor cellsCD8+ T cellsliver metastatic diseaseT cell accumulationregulatory T cellscancer-associated deathsMDSC accumulationmetastatic diseasesuppressor cellsovariectomized miceIFN-ginterferon-gammamale miceclinical challengelivermetastasisestrogenpotential targetCasting A Wide Net On Surgery
Eustache J, Tohme S, Milette S, Rayes R, Tsung A, Spicer J. Casting A Wide Net On Surgery. Annals Of Surgery 2019, 272: 277-283. PMID: 32675540, PMCID: PMC7373444, DOI: 10.1097/sla.0000000000003586.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and Concepts
Academic Achievements & Community Involvement
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honor The Society for Immunotherapy of Cancer Fellowship Award
08/10/2026International AwardThe Society for Immunotherapy of CancerDetailsUnited States
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Mailing Address
Yale School of Medicine
300 George Street
New Haven, Connecticut 06511
United States
Locations
Goran Micevic Laboratory
Lab
300 George Street, Ste 6400
New Haven, CT 06511
Richard A. Flavell Laboratory
Lab
The Anlyan Center
300 Cedar Street, Ste S560-S570
New Haven, CT 06519