Simon Milette, PhD
he/him/his
Postdoctoral AssociateDownloadHi-Res Photo
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Yale School of Medicine
300 George Street
New Haven, Connecticut 06511
United States
Appointments
Dermatology
Primary
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Postdoctoral Associate
Biography
I am a Postdoctoral Associate at Yale School of Medicine and Yale Cancer Center in the laboratory of Dr. Goran Micevic. In close collaboration with the Flavell and Bosenberg groups, my research maps the retroelement landscape of tumor-infiltrating T cells to uncover how epigenetic programs lock T cells into dysfunction within the tumor microenvironment. By targeting these regulatory circuits, my work aims to unlock T cell cytotoxicity, restore anti-cancer immune memory, and engineer durable responses to cancer immunotherapies.
Last Updated on September 03, 2026.
Appointments
Education & Training
- PhD
- McGill University, Experimental Medicine (2024)
- MSc
- McGill University, Experimental Medicine (2018)
- BSc (Hon)
- McGill University, Immunology (2016)
Research
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Overview
Medical Research Interests
Epigenomics; Immunotherapy; Melanoma; Retroelements
Public Health Interests
Bioinformatics; Cancer; Genetics, Genomics, Epigenetics; Immunology; Infectious Diseases
ORCID
0000-0003-2977-0829- View Lab Website
Micevic Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Simon Milette's published research.
Research Interests
Research topics Simon Milette is interested in exploring.
Goran Mićević, MD, PhD
Marcus Bosenberg, MD, PhD
Maya G Deshmukh
Caroline Helen Johnson, PhD
Kelly Olino, MD, FACS
Koonam Park
Immunotherapy
Melanoma
Publications
2025
Lipophilic statins deplete GPX4 to promote ferroptosis and sensitize cancer cells to immune checkpoint blockade
Talty R, Brooks V, McGeary M, Milette S, Zheng S, Flem-Karlsen K, Daniels A, Deshmukh M, Park K, Caraccio W, Yan H, Echeandia-Francis C, McNamara M, Hong S, Kirwin D, Olino K, Johnson C, Bosenberg M, Micevic G, Roy S. Lipophilic statins deplete GPX4 to promote ferroptosis and sensitize cancer cells to immune checkpoint blockade. Molecular Cancer Therapeutics 2025, 25: 759-770. PMID: 41423587, PMCID: PMC12752129, DOI: 10.1158/1535-7163.mct-25-0667.Peer-Reviewed Original ResearchCitationsAltmetricDNA methylation in melanoma immunotherapy: mechanisms and therapeutic opportunities
Deshmukh M, Brooks V, Roy S, Milette S, Bosenberg M, Micevic G. DNA methylation in melanoma immunotherapy: mechanisms and therapeutic opportunities. Clinical Epigenetics 2025, 17: 71. PMID: 40307913, PMCID: PMC12044936, DOI: 10.1186/s13148-025-01865-5.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2024
Exploring the prognostic significance of arm-level copy number alterations in triple-negative breast cancer
Doré S, Ali M, Sorin M, McDowell S, Desharnais L, Breton V, Yu M, Arabzadeh A, Ryan M, Milette S, Quail D, Walsh L. Exploring the prognostic significance of arm-level copy number alterations in triple-negative breast cancer. Oncogene 2024, 43: 2015-2024. PMID: 38744952, PMCID: PMC11196216, DOI: 10.1038/s41388-024-03051-y.Peer-Reviewed Original ResearchCitationsCotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer.
Zhu X, Fu Z, Dutchak K, Arabzadeh A, Milette S, Steinberger J, Morin G, Monast A, Pilon V, Kong T, Adams B, Prando Munhoz E, Hosein H, Fang T, Su J, Xue Y, Rayes R, Sangwan V, Walsh L, Chen G, Quail D, Spicer J, Park M, Dankort D, Huang S. Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer. Cancer Research 2024, 84: 1333-1351. PMID: 38277141, DOI: 10.1158/0008-5472.can-23-1749.Peer-Reviewed Original ResearchCitationsAltmetric
2023
Obesity alters monocyte developmental trajectories to enhance metastasis
McDowell S, Milette S, Doré S, Yu M, Sorin M, Wilson L, Desharnais L, Cristea A, Varol O, Atallah A, Swaby A, Breton V, Arabzadeh A, Petrecca S, Loucif H, Bhagrath A, De Meo M, Lach K, Issac M, Fiset B, Rayes R, Mandl J, Fritz J, Fiset P, Holt P, Dannenberg A, Spicer J, Walsh L, Quail D. Obesity alters monocyte developmental trajectories to enhance metastasis. Journal Of Experimental Medicine 2023, 220: e20220509. PMID: 37166450, PMCID: PMC10182775, DOI: 10.1084/jem.20220509.Peer-Reviewed Original ResearchCitationsAltmetricSingle-cell spatial landscapes of the lung tumour immune microenvironment
Sorin M, Rezanejad M, Karimi E, Fiset B, Desharnais L, Perus L, Milette S, Yu M, Maritan S, Doré S, Pichette É, Enlow W, Gagné A, Wei Y, Orain M, Manem V, Rayes R, Siegel P, Camilleri-Broët S, Fiset P, Desmeules P, Spicer J, Quail D, Joubert P, Walsh L. Single-cell spatial landscapes of the lung tumour immune microenvironment. Nature 2023, 614: 548-554. PMID: 36725934, PMCID: PMC9931585, DOI: 10.1038/s41586-022-05672-3.Peer-Reviewed Original ResearchCitationsAltmetric
2021
A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes’ interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19
Ding J, Hostallero D, Khili M, Fonseca G, Milette S, Noorah N, Guay-Belzile M, Spicer J, Daneshtalab N, Sirois M, Tremblay K, Emad A, Rousseau S. A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes’ interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19. PLOS Computational Biology 2021, 17: e1008810. PMID: 33684134, PMCID: PMC7971900, DOI: 10.1371/journal.pcbi.1008810.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAlgorithmsCell DegranulationComputational BiologyCOVID-19Extracellular TrapsGene Expression RegulationGene Regulatory NetworksGenetic Predisposition to DiseaseHumansLymphohistiocytosis, HemophagocyticModels, BiologicalPandemicsProtein Interaction MapsPulmonary EmbolismSARS-CoV-2ThrombosisViral Proteins
2020
Neutrophil DNA Webs Untangled
Milette S, Quail D, Spicer J. Neutrophil DNA Webs Untangled. Cancer Cell 2020, 38: 164-166. PMID: 32781042, DOI: 10.1016/j.ccell.2020.07.002.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords
2019
Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases
Milette S, Hashimoto M, Perrino S, Qi S, Chen M, Ham B, Wang N, Istomine R, Lowy A, Piccirillo C, Brodt P. Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases. Nature Communications 2019, 10: 5745. PMID: 31848339, PMCID: PMC6917725, DOI: 10.1038/s41467-019-13571-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAnimalsCell Line, TumorColonic NeoplasmsDisease Models, AnimalEstradiolEstrogen AntagonistsEstrogensFemaleHumansLiverLiver NeoplasmsLung NeoplasmsLymphocytes, Tumor-InfiltratingMaleMiceMice, Inbred C57BLMice, KnockoutMyeloid-Derived Suppressor CellsOvariectomyPancreatic NeoplasmsReceptors, Tumor Necrosis Factor, Type IISex FactorsT-Lymphocytes, RegulatoryTamoxifenTumor MicroenvironmentCasting A Wide Net On Surgery
Eustache J, Tohme S, Milette S, Rayes R, Tsung A, Spicer J. Casting A Wide Net On Surgery. Annals Of Surgery 2019, 272: 277-283. PMID: 32675540, PMCID: PMC7373444, DOI: 10.1097/sla.0000000000003586.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
Academic Achievements & Community Involvement
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Featured
honor The Society for Immunotherapy of Cancer Fellowship Award
08/10/2026International AwardThe Society for Immunotherapy of CancerDetailsUnited States
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Mailing Address
Yale School of Medicine
300 George Street
New Haven, Connecticut 06511
United States
Locations
Goran Micevic Laboratory
Lab
300 George Street, Ste 6400
New Haven, CT 06511
Richard A. Flavell Laboratory
Lab
The Anlyan Center
300 Cedar Street, Ste S560-S570
New Haven, CT 06519