Shanshan Liu, PhD
Associate Research Scientist in Cell BiologyCards
About
Research
Publications
2026
SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis
Liu S, Gad M, Li C, Cho K, Liu Y, Wangdu K, Belay V, Millet A, Kojima H, Sanford H, Wölk M, Urnavicius L, Fedorova M, Patti G, Vinogradova E, Hite R, Birsoy K. SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis. Nature Cell Biology 2026, 28: 903-914. PMID: 41998286, DOI: 10.1038/s41556-026-01922-y.Peer-Reviewed Original Research
2023
Autoregulatory control of mitochondrial glutathione homeostasis
Liu Y, Liu S, Tomar A, Yen F, Unlu G, Ropek N, Weber R, Wang Y, Khan A, Gad M, Peng J, Terzi E, Alwaseem H, Pagano A, Heissel S, Molina H, Allwein B, Kenny T, Possemato R, Zhao L, Hite R, Vinogradova E, Mansy S, Birsoy K. Autoregulatory control of mitochondrial glutathione homeostasis. Science 2023, 382: 820-828. PMID: 37917749, PMCID: PMC11170550, DOI: 10.1126/science.adf4154.Peer-Reviewed Original ResearchA mitochondrial SCF‐FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease
Cao Y, Zheng J, Wan H, Sun Y, Fu S, Liu S, He B, Cai G, Cao Y, Huang H, Li Q, Ma Y, Chen S, Wang F, Jiang H. A mitochondrial SCF‐FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease. The EMBO Journal 2023, 42: embj2022113033. PMID: 36896912, PMCID: PMC10308365, DOI: 10.15252/embj.2022113033.Peer-Reviewed Original ResearchChemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction
Yang J, Chen P, Cao Y, Liu S, Wang W, Li L, Li J, Jiang Z, Ma Y, Chen S, Zheng S, Qi X, Jiang H. Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction. Cell Chemical Biology 2023, 30: 278-294.e11. PMID: 36827981, DOI: 10.1016/j.chembiol.2023.02.002.Peer-Reviewed Original Research
2022
Mitochondrial cristae architecture protects against mtDNA release and inflammation
He B, Yu H, Liu S, Wan H, Fu S, Liu S, Yang J, Zhang Z, Huang H, Li Q, Wang F, Jiang Z, Liu Q, Jiang H. Mitochondrial cristae architecture protects against mtDNA release and inflammation. Cell Reports 2022, 41: 111774. PMID: 36476853, DOI: 10.1016/j.celrep.2022.111774.Peer-Reviewed Original ResearchProtocols for analyzing metabolic derangements caused by increased NADH/NAD+ ratio in cell lines and in mice
Liu S, Ma Y, Jiang H. Protocols for analyzing metabolic derangements caused by increased NADH/NAD+ ratio in cell lines and in mice. STAR Protocols 2022, 3: 101120. PMID: 35106502, PMCID: PMC8784396, DOI: 10.1016/j.xpro.2021.101120.Peer-Reviewed Original ResearchIdentification and characterization of novel MPC1 gene variants causing mitochondrial pyruvate carrier deficiency
Jiang H, Alahmad A, Fu S, Fu X, Liu Z, Han X, Li L, Song T, Xu M, Liu S, Wang J, Albash B, Alaqeel A, Catalina V, Prokisch H, Taylor R, McFarland R, Fang F. Identification and characterization of novel MPC1 gene variants causing mitochondrial pyruvate carrier deficiency. Journal Of Inherited Metabolic Disease 2022, 45: 264-277. PMID: 34873722, DOI: 10.1002/jimd.12462.Peer-Reviewed Original Research
2021
Multifaceted roles of mitochondrial stress responses under ETC dysfunction – repair, destruction and pathogenesis
Liu S, Liu S, Jiang H. Multifaceted roles of mitochondrial stress responses under ETC dysfunction – repair, destruction and pathogenesis. The FEBS Journal 2021, 289: 6994-7013. PMID: 34918460, DOI: 10.1111/febs.16323.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGlycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease
Liu S, Fu S, Wang G, Cao Y, Li L, Li X, Yang J, Li N, Shan Y, Cao Y, Ma Y, Dong M, Liu Q, Jiang H. Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease. Cell Metabolism 2021, 33: 1974-1987.e9. PMID: 34270929, DOI: 10.1016/j.cmet.2021.06.013.Peer-Reviewed Original ResearchOXPHOS deficiency activates global adaptation pathways to maintain mitochondrial membrane potential
Liu S, Liu S, He B, Li L, Li L, Wang J, Cai T, Chen S, Jiang H. OXPHOS deficiency activates global adaptation pathways to maintain mitochondrial membrane potential. EMBO Reports 2021, 22: embr202051606. PMID: 33655635, PMCID: PMC8025004, DOI: 10.15252/embr.202051606.Peer-Reviewed Original Research