Genome-wide association study of susceptibility to hospitalised respiratory infections
Williams A, Shrine N, Naghra-van Gijzel H, Betts J, Chen J, Hessel E, John C, Packer R, Reeve N, Yeo A, Abner E, Åsvold B, Auvinen J, Bartz T, Bradford Y, Brumpton B, Campbell A, Cho M, Chu S, Crosslin D, Feng Q, Esko T, Gharib S, Hayward C, Hebbring S, Hveem K, Järvelin M, Jarvik G, Landis S, Larson E, Liu J, Loos R, Luo Y, Moscati A, Mullerova H, Namjou B, Porteous D, Quint J, Ritchie M, Sliz E, Stanaway I, Thomas L, Wilson J, Hall I, Wain L, Michalovich D, Tobin M. Genome-wide association study of susceptibility to hospitalised respiratory infections. Wellcome Open Research 2023, 6: 290. DOI: 10.12688/wellcomeopenres.17230.2.Peer-Reviewed Original ResearchGenome-wide significant signalsExpression quantitative trait lociGenome-wide association studiesStage 1 analysisAssociation studiesRespiratory infection susceptibilityTranscription factor binding activityHomeodomain-containing transcription factorQuantitative trait lociFactor binding activityInverse variance-weighted meta-analysesExpression of PBX3Biological mechanismsGenome-wideUK BiobankCausal genesRespiratory infection casesTrait lociInfection susceptibilityWell-imputedTranscription factor 3Transcription factorsRespiratory infectionsSignificant signalsGenetic determinants