Chenxiang Lin, PhD
Associate Professor of Cell Biology and of Biomedical EngineeringDownloadHi-Res Photo
Cards
Appointments
Cell Biology
Primary
Additional Titles
Associate Director, Nanobiology Institute
Contact Info
Appointments
Cell Biology
Primary
Additional Titles
Associate Director, Nanobiology Institute
Contact Info
Appointments
Cell Biology
Primary
Additional Titles
Associate Director, Nanobiology Institute
Contact Info
About
Titles
Associate Professor of Cell Biology and of Biomedical Engineering
Associate Director, Nanobiology Institute
Appointments
Cell Biology
Associate Professor TenurePrimary
Other Departments & Organizations
Education & Training
- Research Fellow
- Harvard Medical School (2012)
- PhD
- Arizona State University (2009)
- BS
- Peking University (2004)
Research
Overview
Medical Subject Headings (MeSH)
Biophysics; Biosensing Techniques; Cell Biology; Cell Membrane; DNA; Lipid Bilayers; Membrane Fusion; Membranes, Artificial; Nanostructures; Nanotechnology; Nuclear Pore; Nucleic Acid Probes; Reference Standards
ORCID
0000-0001-7041-1946- View Lab Website
Chenxiang Lin Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Chenxiang Lin's published research.
Publications Timeline
A big-picture view of Chenxiang Lin's research output by year.
Research Interests
Research topics Chenxiang Lin is interested in exploring.
Qiancheng Xiong
Longfei Liu
Chunxiang Wu
Erdem Karatekin, PhD
C. Patrick Lusk, PhD
Yong Xiong, PhD
58Publications
4,620Citations
DNA
Nanostructures
Nanotechnology
Lipid Bilayers
Cell Membrane
Biosensing Techniques
Publications
2024
Channel width modulates the permeability of DNA origami-based nuclear pore mimics.
Feng Q, Saladin M, Wu C, Cao E, Zheng W, Zhang A, Bhardwaj P, Li X, Shen Q, Kapinos LE, Kozai T, Mariappan M, Lusk CP, Xiong Y, Lim RYH, Lin C. Channel width modulates the permeability of DNA origami-based nuclear pore mimics. Sci Adv 2024, 10: eadq8773. PMID: 39536094, DOI: 10.1126/sciadv.adq8773.Peer-Reviewed Original ResearchDNA-Based Molecular Clamp for Probing Protein Interactions and Structure under Force
Chung M, Zhou K, Powell J, Lin C, Schwartz M. DNA-Based Molecular Clamp for Probing Protein Interactions and Structure under Force. ACS Nano 2024, 18: 27590-27596. PMID: 39344156, PMCID: PMC11518680, DOI: 10.1021/acsnano.4c08663.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTalin rod domainNegative-stain electron microscopyDouble-stranded DNADNA clampProtein functionRod domainCryptic sitesProtein interactionsMolecular clampCellular mechanotransductionStudy proteinsBiochemical studiesCell biologyAdult physiologyProtein conformationTalinProteinBiochemical scaleMultiple diseasesDNAARPC5LVinculinStructural analysisEmbryogenesisDNA-based devicesDNA nanoswitches pack an anti-cancer punch
Zhou K, Lin C. DNA nanoswitches pack an anti-cancer punch. Nature Nanotechnology 2024, 1-2. PMID: 39209995, DOI: 10.1038/s41565-024-01749-4.Commentaries, Editorials and LettersAltmetricLipid osmosis, membrane tension, and other mechanochemical driving forces of lipid flow
Zhang Y, Lin C. Lipid osmosis, membrane tension, and other mechanochemical driving forces of lipid flow. Current Opinion In Cell Biology 2024, 88: 102377. PMID: 38823338, PMCID: PMC11193448, DOI: 10.1016/j.ceb.2024.102377.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricConceptsMembrane tensionLipid transportNonvesicular lipid transportLipid transfer proteinsOrganelle biogenesisLipid transferMembrane proteinsMembrane domainsLipid homeostasisBiological functionsLipid flowMembrane protein densityTransfer proteinMembrane regionsProtein densityProteinMembraneLipidBiogenesisOrganelles
2023
Recent Advances in DNA Origami-Engineered Nanomaterials and Applications
Zhan P, Peil A, Jiang Q, Wang D, Mousavi S, Xiong Q, Shen Q, Shang Y, Ding B, Lin C, Ke Y, Liu N. Recent Advances in DNA Origami-Engineered Nanomaterials and Applications. Chemical Reviews 2023, 123: 3976-4050. PMID: 36990451, PMCID: PMC10103138, DOI: 10.1021/acs.chemrev.3c00028.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsDNA origami techniquePaul RothemundDNA nanotechnologyOrigami techniqueExciting achievementsNanomaterialsMaterials scienceRecent progressRecent advancesNanotechnologyUseful applicationsApplicationsRothemundSignificant advancesUnexplored research avenuesOriginal proposalFieldPhysicsMathematicsEngineeringAdvancesUnique fieldThe capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores
Shen Q, Kumari S, Xu C, Jang S, Shi J, Burdick R, Levintov L, Xiong Q, Wu C, Devarkar S, Tian T, Tripler T, Hu Y, Yuan S, Temple J, Feng Q, Lusk C, Aiken C, Engelman A, Perilla J, Pathak V, Lin C, Xiong Y. The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2202815120. PMID: 36943880, PMCID: PMC10068764, DOI: 10.1073/pnas.2202815120.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHIV-1 capsidC-terminal tail regionTriple arginine motifNuclear pore complexPhenylalanine-glycine motifsBipartite motifNuclear importPore complexNuclear poresNuclear entryNup153Capsid latticeInteraction moduleProtein latticeCA assemblyCA hexamersIntact capsidsNucleoporinsHIV-1 coreMotifCapsidTail regionIntact formInfection studiesMechanistic evidenceModeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels
Shen Q, Feng Q, Wu C, Xiong Q, Tian T, Yuan S, Shi J, Bedwell G, Yang R, Aiken C, Engelman A, Lusk C, Lin C, Xiong Y. Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels. Nature Structural & Molecular Biology 2023, 30: 425-435. PMID: 36807645, PMCID: PMC10121901, DOI: 10.1038/s41594-023-00925-9.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNuclear pore complexHIV-1 nuclear entryNuclear entryNuclear importNPC central channelPore complexHost nucleusCapsid dockingVirus genomeAffinity gradientNup153Central channelMechanistic insightsMolecular interactionsCapsidNucleoporinsNup358Nup62GenomeNucleusVirusDockingVirus-1 infectionImportComplexesCLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state–sensitive manner
Luo W, Demidov V, Shen Q, Girão H, Chakraborty M, Maiorov A, Ataullakhanov F, Lin C, Maiato H, Grishchuk E. CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state–sensitive manner. Science Advances 2023, 9: eabq5404. PMID: 36598991, PMCID: PMC9812398, DOI: 10.1126/sciadv.abq5404.Peer-Reviewed Original ResearchCitationsAltmetric
2022
Functionalized DNA-Origami-Protein Nanopores Generate Large Transmembrane Channels with Programmable Size-Selectivity
Shen Q, Xiong Q, Zhou K, Feng Q, Liu L, Tian T, Wu C, Xiong Y, Melia T, Lusk C, Lin C. Functionalized DNA-Origami-Protein Nanopores Generate Large Transmembrane Channels with Programmable Size-Selectivity. Journal Of The American Chemical Society 2022, 145: 1292-1300. PMID: 36577119, PMCID: PMC9852090, DOI: 10.1021/jacs.2c11226.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsExchange of macromoleculesCholesterol-rich membranesHybrid nanoporesSynthetic biologyBiophysical toolsSynthetic cellsTransmembrane channelsTransmembrane nanoporesDNA ringsProtein nanoporeCell membraneBacterial toxinsDNA origami techniqueLipid membranesAnalytical chemistryMacromolecule sizeDNA origamiMembraneProgrammable sizeNanoporesSized poresNucleoporinsAverage inner diameterCellsPneumolysinActuating tension-loaded DNA clamps drives membrane tubulation
Liu L, Xiong Q, Xie C, Pincet F, Lin C. Actuating tension-loaded DNA clamps drives membrane tubulation. Science Advances 2022, 8: eadd1830. PMID: 36223466, PMCID: PMC9555772, DOI: 10.1126/sciadv.add1830.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDNA clampMembrane tubulationMembrane dynamicsMembrane-remodeling eventsVesicle tubulationConformational changesSpatiotemporal controlDNA signalsCell membraneDNA nanostructuresTubulationMembrane deformationClosed stateOpen stateSelf-assembled DNA nanostructuresOrganismsProteinMembrane tubeArtificial systemsTube widthMembraneDynamics
Academic Achievements & Community Involvement
honor Odyssey Award
Regional AwardRichard and Susan Smith Family FoundationDetails09/01/2020United Stateshonor Director's New Innovator Award
National AwardNational Institutes of HealthDetails09/30/2014United States
News
News
- February 19, 2023Source: Nature Structural & Molecular Biology
Modeling HIV-1 nuclear entry with DNA-origami nuclear pore mimics
- May 02, 2022Source: Nature Methods
A better way to PAINT your sample for super-resolution imaging
- March 30, 2021Source: Nature Chemistry
DNA helps sort out liposomes and biophysical problems
- February 07, 2021Source: BioRxiv
A DNA-origami NanoTrap for studying the diffusion barriers
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Chenxiang Lin Lab
Lab
West Campus Integrative Science & Technology Center
850 West Campus Drive, Rm 213
West Haven, CT 06516