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Super-resolution microscopy goes high-throughput
Super-resolution microscopy can reveal small subcellular structures invisible to classical light microscopes thanks to its tenfold improved resolution (20-70 nm). The broad application of the new technology has however been hampered by the low throughput of these new technologies: in a typical workday, a researcher can image only about 10 mammalian cells. The Bewersdorf and Baddeley labs have now published a next-generation super-resolution microscope which can image 1,000 to 10,000 cells in an automated manner in 24 hours. This enables future, previously inaccessible studies that require the comparison of many experimental conditions or have high demands for sample size.
Source: Nature Biotechnology