The CMITT article "PET Mapping of Receptor Occupancy Using Joint Direct Parametric Reconstruction" was selected as a featured article in the March edition of IEEE Transactions on Biomedical Engineering.
Receptor occupancy (RO) studies using PET neuroimaging are crucial for central nervous system drug development. Traditionally RO estimated by comparing binding potential changes between baseline and post-drug injection PET scans. A novel joint direct parametric reconstruction method developed at YSM shows improved accuracy and precision in RO estimation, particularly in low-binding regions, as demonstrated in both simulation and preclinical experiments.
T. Marin et al., "PET Mapping of Receptor Occupancy Using Joint Direct Parametric Reconstruction," in IEEE Transactions on Biomedical Engineering, vol. 72, no. 3, pp. 1057-1066, March 2025, doi: 10.1109/TBME.2024.3486191