2024
Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever
Kotliar D, Raju S, Tabrizi S, Odia I, Goba A, Momoh M, Sandi J, Nair P, Phelan E, Tariyal R, Eromon P, Mehta S, Robles-Sikisaka R, Siddle K, Stremlau M, Jalloh S, Gire S, Winnicki S, Chak B, Schaffner S, Pauthner M, Karlsson E, Chapin S, Kennedy S, Branco L, Kanneh L, Vitti J, Broodie N, Gladden-Young A, Omoniwa O, Jiang P, Yozwiak N, Heuklom S, Moses L, Akpede G, Asogun D, Rubins K, Kales S, Happi A, Iruolagbe C, Dic-Ijiewere M, Iraoyah K, Osazuwa O, Okonkwo A, Kunz S, McCormick J, Khan S, Honko A, Lander E, Oldstone M, Hensley L, Folarin O, Okogbenin S, Günther S, Ollila H, Tewhey R, Okokhere P, Schieffelin J, Andersen K, Reilly S, Grant D, Garry R, Barnes K, Happi C, Sabeti P. Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever. Nature Microbiology 2024, 9: 751-762. PMID: 38326571, PMCID: PMC10914620, DOI: 10.1038/s41564-023-01589-3.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAssociation studiesSignatures of positive selectionHuman genetic variationFatal outcomeNigerian cohortLassa feverLassa virusFunctional characterization assaysVariant associationsGenetic variationHuman leukocyte antigen typingPositive selectionAssociated with decreased riskSevere Lassa feverCases of Lassa feverViral pathogenesisEntry factorsLASV infectionCharacterization assaysMild symptomsFeverAntigenic typesSeroprevalence surveyCohort
2022
LRRC15 inhibits SARS-CoV-2 cellular entry in trans
Song J, Chow RD, Peña-Hernández MA, Zhang L, Loeb SA, So EY, Liang OD, Ren P, Chen S, Wilen CB, Lee S. LRRC15 inhibits SARS-CoV-2 cellular entry in trans. PLOS Biology 2022, 20: e3001805. PMID: 36228039, PMCID: PMC9595563, DOI: 10.1371/journal.pbio.3001805.Peer-Reviewed Original ResearchConceptsExpression of LRRC15Receptor-binding domainViral entryAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSARS-CoV-2 cellular entrySyndrome coronavirus 2 infectionSARS-CoV-2 entrySpike-mediated entryCoronavirus 2 infectionCOVID-19 patientsCellular entry factorsSARS-CoV-2Attachment factorsACE2-negative cellsEnzyme 2Receptor angiotensinEntry factorsProtective roleLRRC15Spike proteinSame cell typeCRISPR activation screensACE2Cellular entry
2021
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity
Bui LT, Winters NI, Chung MI, Joseph C, Gutierrez AJ, Habermann AC, Adams TS, Schupp JC, Poli S, Peter LM, Taylor CJ, Blackburn JB, Richmond BW, Nicholson AG, Rassl D, Wallace WA, Rosas IO, Jenkins RG, Kaminski N, Kropski JA, Banovich NE. Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity. Nature Communications 2021, 12: 4314. PMID: 34262047, PMCID: PMC8280215, DOI: 10.1038/s41467-021-24467-0.Peer-Reviewed Original ResearchConceptsChronic lung diseaseLung diseaseImmune responseSARS-CoV-2 entry factorsSevere coronavirus disease-19SARS-CoV-2 infectionWorse COVID-19 outcomesSARS-CoV-2 entryAdaptive immune responsesCoronavirus disease-19COVID-19 outcomesInnate immune responseInflammatory gene expression programSimilar cellular distributionPoor outcomePeripheral lungViral exposureDisease-19Inflammatory microenvironmentEntry factorsLung epitheliumLung cellsViral replicationAT2 cellsBasal differences
2020
CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner
Furlong K, Biering SB, Choi J, Wilen CB, Orchard RC, Wobus CE, Nelson CA, Fremont DH, Baldridge MT, Randall G, Hwang S. CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner. Journal Of Virology 2020, 94: 10.1128/jvi.00837-20. PMID: 32581099, PMCID: PMC7431780, DOI: 10.1128/jvi.00837-20.Peer-Reviewed Original ResearchConceptsBone marrow-derived macrophagesCell type-dependent mannerType-dependent mannerCell typesMacrophage-like cellsRobust experimental systemMNV infectionRelated murine norovirusSpecific cell typesCorresponding mutantsMarrow-derived macrophagesMurine norovirus infectionEntry factorsMurine norovirusCD300lfCause of gastroenteritisNonpermissive cellsProteinaceous receptorsConfer resistanceHuman cellsHost cellsDifferent allelesAmino acidsC57BL/6J allelePermissive cells
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