2015
Mosquito Defense Strategies against Viral Infection
Cheng G, Liu Y, Wang P, Xiao X. Mosquito Defense Strategies against Viral Infection. Trends In Parasitology 2015, 32: 177-186. PMID: 26626596, PMCID: PMC4767563, DOI: 10.1016/j.pt.2015.09.009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArbovirusesCulicidaeHemolymphNeuronsRNA InterferenceSalivary GlandsVirus ReplicationConceptsViral infectionMosquito antiviral immunityEfficient antiviral strategiesPathological sequelaePersistent infectionAntiviral immunityArbovirus infectionViral replicationAntiviral strategiesInfectionMosquito tissuesViral diseasesGlobal healthViral propagationMosquitoesTissueNatural vectorSequelaeSpecific tissuesDiseaseImmunity
2014
Innexin AGAP001476 Is Critical for Mediating Anti-Plasmodium Responses in Anopheles Mosquitoes
Li MW, Wang J, Zhao YO, Fikrig E. Innexin AGAP001476 Is Critical for Mediating Anti-Plasmodium Responses in Anopheles Mosquitoes. Journal Of Biological Chemistry 2014, 289: 24885-24897. PMID: 25035430, PMCID: PMC4155657, DOI: 10.1074/jbc.m114.554519.Peer-Reviewed Original ResearchConceptsAnti-Plasmodium responseToll pathwayInnate immune responseGap junction proteinIMD pathwaySignal transductionExtracellular communicationSimultaneous knockdownAnopheles gambiaeImmune responseMidgut epitheliumInhibitor studiesKnockdownPlasmodium falciparum infectionCactusBlood mealGap junctionsVitellogenin levelsOocyst numbersAnopheles mosquitoesJunction proteinsCritical rolePathwayMRNA levelsMosquitoesDynamic peripheral traction forces balance stable neurite tension in regenerating Aplysia bag cell neurons
Hyland C, Mertz AF, Forscher P, Dufresne E. Dynamic peripheral traction forces balance stable neurite tension in regenerating Aplysia bag cell neurons. Scientific Reports 2014, 4: 4961. PMID: 24825441, PMCID: PMC4019958, DOI: 10.1038/srep04961.Peer-Reviewed Original ResearchRegeneration of Aplysia Bag Cell Neurons is Synergistically Enhanced by Substrate-Bound Hemolymph Proteins and Laminin
Hyland C, Dufresne ER, Forscher P. Regeneration of Aplysia Bag Cell Neurons is Synergistically Enhanced by Substrate-Bound Hemolymph Proteins and Laminin. Scientific Reports 2014, 4: 4617. PMID: 24722588, PMCID: PMC3983596, DOI: 10.1038/srep04617.Peer-Reviewed Original ResearchConceptsBag cell neuronsHemolymph proteinsRespiratory protein hemocyaninAplysia bag cell neuronsProtein complexesFurther molecular characterizationAddition of hemolymphHigh molecular weight proteinsCell neuronsMolecular weight proteinsMolecular characterizationCellular targetsExtracellular matrixProteinNervous system repairNovel synergistic effectWeight proteinsLaminin substrateHumoral proteinsLamininPossible cooperationActive factorsMigration rateEndogenous factorsPotential relevance
2013
Genetic Determinants of Phosphate Response in Drosophila
Bergwitz C, Wee MJ, Sinha S, Huang J, DeRobertis C, Mensah LB, Cohen J, Friedman A, Kulkarni M, Hu Y, Vinayagam A, Schnall-Levin M, Berger B, Perkins LA, Mohr SE, Perrimon N. Genetic Determinants of Phosphate Response in Drosophila. PLOS ONE 2013, 8: e56753. PMID: 23520455, PMCID: PMC3592877, DOI: 10.1371/journal.pone.0056753.Peer-Reviewed Original ResearchConceptsLarval developmentGenome-wide RNAi screenDrosophila larval developmentGenetic determinantsImportant cellular processesNovel genetic determinantsAdult life spanLife spanExtracellular phosphate levelsD-rafRNAi-mediated inhibitionRNAi screenDrosophila melanogasterPhosphate responseCellular processesResponse to phosphateAdult fliesCandidate genesLive fliesMAPK activationAvailability of phosphateCellular responsesHigh phosphate mediumMalpighian tubulesReduced life span
2012
Small molecule perimeter defense in entomopathogenic bacteria
Crawford JM, Portmann C, Zhang X, Roeffaers MB, Clardy J. Small molecule perimeter defense in entomopathogenic bacteria. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 10821-10826. PMID: 22711807, PMCID: PMC3390839, DOI: 10.1073/pnas.1201160109.Peer-Reviewed Original ResearchConceptsBacterial cell surfaceConfocal fluorescence microscopyCell surfacePhysical associationHuman pathogen Vibrio choleraeInsect innate immune systemBiochemical assaysInnate immune systemPathogen Vibrio choleraeFluorescence microscopyPrecursor-directed biosynthesisE. coli cellsInsect pathogensPathway mutantsEntomopathogenic bacteriaHeterologous expressionXenorhabdus nematophilaColi cellsEscherichia coliVibrio choleraeClass of moleculesBioorthogonal probesEffective inhibitor concentrationBiosynthesisHost defenseObligate Symbionts Activate Immune System Development in the Tsetse Fly
Weiss BL, Maltz M, Aksoy S. Obligate Symbionts Activate Immune System Development in the Tsetse Fly. The Journal Of Immunology 2012, 188: 3395-3403. PMID: 22368278, PMCID: PMC3311772, DOI: 10.4049/jimmunol.1103691.Peer-Reviewed Original ResearchConceptsSymbiotic bacteriaImmune system developmentNovel evolutionary adaptationImmunity-related genesObligate symbiontsSymbiotic microbesObligate mutualistsViviparous modeProper immune system functionEvolutionary adaptationPhagocytic hemocytesMolecular mechanismsCell extractsMolecular componentsSusceptible phenotypeNonpathogenic Escherichia coliEscherichia coliTsetse fliesImmune systemFliesAtypical expressionHemocytesImmune system functionPhenotypeTsetse
2011
Ixodes scapularis salivary gland protein P11 facilitates migration of Anaplasma phagocytophilum from the tick gut to salivary glands
Liu L, Narasimhan S, Dai J, Zhang L, Cheng G, Fikrig E. Ixodes scapularis salivary gland protein P11 facilitates migration of Anaplasma phagocytophilum from the tick gut to salivary glands. EMBO Reports 2011, 12: 1196-1203. PMID: 21921936, PMCID: PMC3207102, DOI: 10.1038/embor.2011.177.Peer-Reviewed Original ResearchLipophorin acts as a shuttle of lipids to the milk gland during tsetse fly pregnancy
Benoit JB, Yang G, Krause TB, Patrick KR, Aksoy S, Attardo GM. Lipophorin acts as a shuttle of lipids to the milk gland during tsetse fly pregnancy. Journal Of Insect Physiology 2011, 57: 1553-1561. PMID: 21875592, PMCID: PMC3209505, DOI: 10.1016/j.jinsphys.2011.08.009.Peer-Reviewed Original ResearchConceptsHemolymph lipid levelsLipid levelsMilk glandRole of LpSecond gonotrophic cycleFat bodyGonotrophic cycleCarrier lipoproteinsFirst gonotrophic cycleFemale reproductive cycleTsetse reproductionMother's uterusPregnant femalesLipid mobilizationUterine fluidGlandSingle gene sequencesViviparous tsetse flyPregnancyLarval gut contentsUterusAdult fat bodyOvariesLipid transport proteinsOocyte developmentMolecular Interactions that Enable Movement of the Lyme Disease Agent from the Tick Gut into the Hemolymph
Zhang L, Zhang Y, Adusumilli S, Liu L, Narasimhan S, Dai J, Zhao YO, Fikrig E. Molecular Interactions that Enable Movement of the Lyme Disease Agent from the Tick Gut into the Hemolymph. PLOS Pathogens 2011, 7: e1002079. PMID: 21695244, PMCID: PMC3111543, DOI: 10.1371/journal.ppat.1002079.Peer-Reviewed Original ResearchConceptsLyme disease agentB. burgdorferi burdenTick gutOuter surface lipoproteinsTick gut proteinsSalivary gland infectionIxodes scapularis ticksInfection resultsMouse infectionDisease agentsGland infectionLyme diseaseBorrelia burgdorferiScapularis ticksB. burgdorferiCausative agentInfectionBurgdorferiGutGut proteinsSpirochetesTick hemolymphTicksAgentsHemolymph
2010
Regulating Alternative Lifestyles in Entomopathogenic Bacteria
Crawford JM, Kontnik R, Clardy J. Regulating Alternative Lifestyles in Entomopathogenic Bacteria. Current Biology 2010, 20: 69-74. PMID: 20022247, PMCID: PMC2821981, DOI: 10.1016/j.cub.2009.10.059.Peer-Reviewed Original ResearchConceptsAntibiotic productionMetabolic shiftNematode digestive tractBacterial proton motive forceBacterial metabolic regulationProton motive forceGenus PhotorhabdusTransporter PutPEntomopathogenic bacteriaInsect larvaeSmall moleculesInsecticidal toxinsNematode hostsInsect hemolymphBacterial pathwaysXenorhabdus nematophilaFungal competitorsDigestive tractL-prolineMetabolic regulationMotive forceHost environmentPhotorhabdusTT01Bacteria
1999
Environmental Upregulation of the Atrial Natriuretic Peptide Gene in the Living Fossil,Limulus polyphemus
Vesely M, Vesely D. Environmental Upregulation of the Atrial Natriuretic Peptide Gene in the Living Fossil,Limulus polyphemus. Biochemical And Biophysical Research Communications 1999, 254: 751-756. PMID: 9920813, DOI: 10.1006/bbrc.1998.9990.Peer-Reviewed Original ResearchConceptsGene expressionLimulus polyphemusNorthern blot analysisLow salinityVertebrate heartLiving fossilPeptide genesMessenger RNAHorseshoe crabsPeptide gene expressionBlot analysisANP gene expressionFreshwaterMedium salinityGillsExpressionSalinityAtrial natriuretic peptide gene expressionNatriuretic peptide genePolyphemusAtrial natriuretic peptide geneGenesRNACrabsFossils
1976
Neoaplectana carpocapsae: Encapsulation in Aedes aegypti and changes in host hemocytes and hemolymph proteins
Andreadis T, Hall D. Neoaplectana carpocapsae: Encapsulation in Aedes aegypti and changes in host hemocytes and hemolymph proteins. Experimental Parasitology 1976, 39: 252-261. PMID: 816666, DOI: 10.1016/0014-4894(76)90125-9.Peer-Reviewed Original Research
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