2024
Targeting β-Catenin Protein Degradation in Refractory B-Cell Malignancies
Cosgun K, Robinson M, Agadzhanian N, Berning P, Fonseca-Arce D, Leveille E, Kothari S, Davids M, Jellusova J, Müschen M. Targeting β-Catenin Protein Degradation in Refractory B-Cell Malignancies. Blood 2024, 144: 1412. DOI: 10.1182/blood-2024-208598.Peer-Reviewed Original ResearchProtein degradationRepression of MYCTranscriptional repression of MYCTranscriptional repressionPromote survivalProteasome inhibitorsProtein degradation pathwaysCell typesN-terminal residuesInduce cell deathRefractory B-cell malignanciesB-cateninB-cell malignanciesRNAi screenInteractome studiesB cell selectionRepressive complexesGene dependenciesProteasomal degradationB cellsChemogenomic screensProteasome inhibitor bortezomibActivated mycDeletion of Ctnnb1Cell death
2023
The C. elegans anchor cell transcriptome: ribosome biogenesis drives cell invasion through basement membrane
Costa D, Kenny-Ganzert I, Chi Q, Park K, Kelley L, Garde A, Matus D, Park J, Yogev S, Goldstein B, Gibney T, Pani A, Sherwood D. The C. elegans anchor cell transcriptome: ribosome biogenesis drives cell invasion through basement membrane. Development 2023, 150 PMID: 37039075, PMCID: PMC10259517, DOI: 10.1242/dev.201570.Peer-Reviewed Original ResearchConceptsRibosome biogenesisCell invasionAnchor cell invasionTranslation of proteinsFocused RNAi screenGene expression profilesAC invasionRibosome productionRNAi screenEndomembrane systemBM transmigrationRibosomal proteinsSec61 transloconCell transcriptomeBasement membrane barriersGene enrichmentExpression profilesTumor proteinTranscriptomeER stressCancer progressionInvasion regulatorsMembrane barrierProteinBiogenesis
2014
Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response
Pulloor NK, Nair S, McCaffrey K, Kostic AD, Bist P, Weaver JD, Riley AM, Tyagi R, Uchil PD, York JD, Snyder SH, García-Sastre A, Potter BV, Lin R, Shears SB, Xavier RJ, Krishnan MN. Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response. PLOS Pathogens 2014, 10: e1003981. PMID: 24586175, PMCID: PMC3937324, DOI: 10.1371/journal.ppat.1003981.Peer-Reviewed Original ResearchConceptsInositol pyrophosphatesHuman genome-wide RNAi screenGenome-wide RNAi screenNovel regulatory proteinPattern recognition receptor RIGActivation of IRF3RNAi screenPositive regulatorTranscription factorsType I interferon responseType I interferon productionNovel regulatorRegulatory proteinsKinase activityBiochemical experimentsPhosphoryl transferIntact cellsInnate immune responseMetabolic pathwaysInterferon transcriptionGlobal regulationIRF3 activationCellular infectionPPIP5K2PPIP5K1A Regulatory Network of Drosophila Germline Stem Cell Self-Renewal
Yan D, Neumüller RA, Buckner M, Ayers K, Li H, Hu Y, Yang-Zhou D, Pan L, Wang X, Kelley C, Vinayagam A, Binari R, Randklev S, Perkins LA, Xie T, Cooley L, Perrimon N. A Regulatory Network of Drosophila Germline Stem Cell Self-Renewal. Developmental Cell 2014, 28: 459-473. PMID: 24576427, PMCID: PMC3998650, DOI: 10.1016/j.devcel.2014.01.020.Peer-Reviewed Original ResearchConceptsGermline stem cellsSelf-renewal factorsDrosophila female germline stem cellsStem cellsDifferent stem cell lineagesLarge-scale RNAi screenFemale germline stem cellsLoss of Set1Stem Cell Self-RenewalSpecific genetic networksHistone methyltransferase Set1Stem cell identityCell fate decisionsStem cell lineagesCell Self-RenewalSelf-renewal genesRNAi screenDistinct fatesFate decisionsGSC maintenanceCell identityCell fateRegulatory networksGenetic networksNeural stem cells
2013
Genetic Determinants of Phosphate Response in Drosophila
Bergwitz C, Wee MJ, Sinha S, Huang J, DeRobertis C, Mensah LB, Cohen J, Friedman A, Kulkarni M, Hu Y, Vinayagam A, Schnall-Levin M, Berger B, Perkins LA, Mohr SE, Perrimon N. Genetic Determinants of Phosphate Response in Drosophila. PLOS ONE 2013, 8: e56753. PMID: 23520455, PMCID: PMC3592877, DOI: 10.1371/journal.pone.0056753.Peer-Reviewed Original ResearchConceptsLarval developmentGenome-wide RNAi screenDrosophila larval developmentGenetic determinantsImportant cellular processesNovel genetic determinantsAdult life spanLife spanExtracellular phosphate levelsD-rafRNAi-mediated inhibitionRNAi screenDrosophila melanogasterPhosphate responseCellular processesResponse to phosphateAdult fliesCandidate genesLive fliesMAPK activationAvailability of phosphateCellular responsesHigh phosphate mediumMalpighian tubulesReduced life span
2012
Comparative Genomics Reveals Two Novel RNAi Factors in Trypanosoma brucei and Provides Insight into the Core Machinery
Barnes RL, Shi H, Kolev NG, Tschudi C, Ullu E. Comparative Genomics Reveals Two Novel RNAi Factors in Trypanosoma brucei and Provides Insight into the Core Machinery. PLOS Pathogens 2012, 8: e1002678. PMID: 22654659, PMCID: PMC3359990, DOI: 10.1371/journal.ppat.1002678.Peer-Reviewed Original ResearchConceptsRNA interferenceT. bruceiComparative genomicsTrypanosoma bruceiMechanism of RNAiCatalog of genesCore RNAi machineryWide RNAi screenArgonaute 1 proteinNext-generation IlluminaRepertoire of factorsLoss of fitnessDistinct developmental stagesAncient eukaryotesRNAi factorsCore machineryRNAi machineryRNAi screenRNAi toolTrypanosomatid protozoaDuplex siRNAsRNAi efficiencyHuman parasitesMolecular explorationBrucei
2011
C. elegans meg‐1 and meg‐2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival
Kapelle WS, Reinke V. C. elegans meg‐1 and meg‐2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival. Genesis 2011, 49: 380-391. PMID: 21305687, DOI: 10.1002/dvg.20726.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsCell ProliferationCell SurvivalDisorders of Sex DevelopmentEmbryo, NonmammalianEpistasis, GeneticFemaleGene Expression Regulation, DevelopmentalGerm CellsLuminescent ProteinsMaleRNA InterferenceRNA-Binding ProteinsTime FactorsConceptsGerm cell proliferationMeg 1Germ cellsEmbryonic primordial germ cellsTargeted RNAi screenPrimordial germ cellsCell proliferationGerm cell survivalGerm lineageP granulesRNAi screenLarval stagesMEG 2Cell survivalFamily membersMultiple pathwaysGerm cell degenerationPhenotypeSterilityProliferationOptimal proliferationCellsCell degenerationEmbryogenesisLineages
2010
Regulation of lin-4 miRNA expression, organismal growth and development by a conserved RNA binding protein in C. elegans
Bracht J, Van Wynsberghe P, Mondol V, Pasquinelli A. Regulation of lin-4 miRNA expression, organismal growth and development by a conserved RNA binding protein in C. elegans. Developmental Biology 2010, 348: 210-221. PMID: 20937268, PMCID: PMC2982876, DOI: 10.1016/j.ydbio.2010.10.003.Peer-Reviewed Original ResearchConceptsLin-4 miRNALin-4C. elegansLin-14Organismal growthLin-28Developmental timing pathwayRNA-binding proteinsExpression of target genesRNAi screenIndependent transcriptsLarval fateTime pathwaysBinding proteinTarget genesRNALarval stageTranscriptionGenesProteinExpressionMiRNA expressionMiRNAsYeastRNAi
2005
A systematic RNAi screen for longevity genes in C. elegans
Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS. A systematic RNAi screen for longevity genes in C. elegans. Genes & Development 2005, 19: 1544-1555. PMID: 15998808, PMCID: PMC1172061, DOI: 10.1101/gad.1308205.Peer-Reviewed Original ResearchConceptsLongevity genesGenome-wide functional genomics screenDAF-16/FOXO transcription factorRNA interferenceDAF-16/FOXONew longevity genesSystematic RNAi screenFunctional genomic screensFOXO transcription factorsLarge-scale RNA interferenceCandidate longevity genesRNAi inactivationAnimal phylogenyRNAi screenC. elegansGenetic interactionsGenomic screenSignal transductionTranscription factorsDaf-2Gene expressionProtein deacetylaseProtein turnoverGenesPathway
2002
A Targeted RNAi Screen for Genes Involved in Chromosome Morphogenesis and Nuclear Organization in the Caenorhabditis elegans Germline
Colaiácovo M, Stanfield G, Reddy K, Reinke V, Kim S, Villeneuve A. A Targeted RNAi Screen for Genes Involved in Chromosome Morphogenesis and Nuclear Organization in the Caenorhabditis elegans Germline. Genetics 2002, 162: 113-128. PMID: 12242227, PMCID: PMC1462232, DOI: 10.1093/genetics/162.1.113.Peer-Reviewed Original ResearchConceptsChromosome morphogenesisNuclear organizationRNA interferenceCaenorhabditis elegans germlineFunctional genomic strategiesMeiotic prophase eventsTargeted RNAi screenGene expression surveyDNA microarray technologyGermline phenotypeGermline proliferationMeiosis genesChromosome organizationMitotic growthRNAi screenGenomic strategiesMeiotic progressionMeiotic prophaseExpression profilesMicroarray technologyGermlineGenesMorphogenesisCaenorhabditisProphase
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