A large-scale insertional mutagenesis screen in zebrafish
Amsterdam A, Burgess S, Golling G, Chen W, Sun Z, Townsend K, Farrington S, Haldi M, Hopkins N. A large-scale insertional mutagenesis screen in zebrafish. Genes & Development 1999, 13: 2713-2724. PMID: 10541557, PMCID: PMC317115, DOI: 10.1101/gad.13.20.2713.Peer-Reviewed Original ResearchConceptsLarge-scale insertional mutagenesis screenInsertional mutagenesis screenEmbryonic lethal mutationsMutagenesis screenLethal mutationsRecessive embryonic lethal mutationsMutated genesProviral insertionEfficiency of mutagenesisBlastula-stage embryosFrequency of mutationsChemical mutagen ENUDominant mutantsGene cloningInsertional mutagenRecessive mutantGerm lineEmbryonic mutationsFounder fishDominant mutationsMutantsGenesDevelopmental defectsPilot screenMutations
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