2023
A narrative review of non-racemic amisulpride (SEP-4199) for treatment of depressive symptoms in bipolar disorder and LB-102 for treatment of schizophrenia
Wu J, Kwan A, Rhee T, Ho R, d’Andrea G, Martinotti G, Teopiz K, Ceban F, McIntyre R. A narrative review of non-racemic amisulpride (SEP-4199) for treatment of depressive symptoms in bipolar disorder and LB-102 for treatment of schizophrenia. Expert Review Of Clinical Pharmacology 2023, 16: 1085-1092. PMID: 37864424, DOI: 10.1080/17512433.2023.2274538.Peer-Reviewed Original ResearchConceptsDepressive symptomsSide effectsBipolar disorderRecent phase 2 trialsPhase 2 trialPhase 1 studyTreatment-resistant schizophreniaExtrapyramidal side effectsD2 receptor bindingReceptor-mediated effectsTreatment of schizophreniaMajor depressive disorderImproved treatment strategiesBipolar disorder IDevelopment of SEPAntidepressant effectsDepressive disorderTreatment strategiesPharmacological profileLow dosesNarrative reviewDisorder ISymptomsAmisulprideReceptor binding
2005
Cytokines and normal sleep
Kapsimalis F, Richardson G, Opp MR, Kryger M. Cytokines and normal sleep. Current Opinion In Pulmonary Medicine 2005, 11: 481-484. PMID: 16217172, DOI: 10.1097/01.mcp.0000183062.98665.6b.Peer-Reviewed Original ResearchConceptsNon-rapid eye movement sleepEye movement sleepNeurohormonal systemsMovement sleepSpontaneous non-rapid eye movement sleepMultiple biologic actionsHypothalamic preoptic areaReceptor-mediated effectsTumor necrosis factorNitric oxide synthesisEffects of cytokinesDirect receptor-mediated effectsImmune system responseMechanism of actionSleep-wake regulationSite of actionAdrenal axisBasal forebrainPreoptic areaNecrosis factorInterleukin-1Adrenal axesNormal sleepCytokinesOxide synthesis
1996
Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression.
Caulin-Glaser T, Watson C, Pardi R, Bender J. Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression. Journal Of Clinical Investigation 1996, 98: 36-42. PMID: 8690801, PMCID: PMC507398, DOI: 10.1172/jci118774.Peer-Reviewed Original ResearchConceptsCultured human umbilical vein ECEndothelial cell adhesion molecule expressionVascular cell adhesion molecule-1 inductionEstrogen receptor-mediated effectsCardiovascular protective roleCell adhesion molecule expressionAge-matched malesIncidence of atherosclerosisReceptor-mediated effectsAdhesion molecule expressionEndothelial cell activationHuman umbilical vein ECSimilar risk profilesSelectin mRNA levelsIL-1 activationPremenopausal womenAntagonist ICIMolecule expressionMononuclear leukocytesE-selectinChemotactic factorsCytokines resultsProtective roleCell activationLeukocyte adhesion
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