2023
Shared retinoic acid responsive enhancers coordinately regulate nascent transcription of Hoxb coding and non-coding RNAs in the developing mouse neural tube
Afzal Z, Lange J, Nolte C, McKinney S, Wood C, Paulson A, De Kumar B, Unruh J, Slaughter B, Krumlauf R. Shared retinoic acid responsive enhancers coordinately regulate nascent transcription of Hoxb coding and non-coding RNAs in the developing mouse neural tube. Development 2023, 150: dev201259. PMID: 37102683, PMCID: PMC10233718, DOI: 10.1242/dev.201259.Peer-Reviewed Original ResearchConceptsNascent transcriptionDynamic regulatory interactionsHox gene expressionCis-regulatory elementsRetinoic acid response elementMouse neural tubeTranscription of genesNon-coding RNAAcid response elementSingle-molecule fluorescentRetinoic acid responseMutant embryosHOXB clusterHox expressionAxial identityHoxb genesRegulatory interactionsTranscriptional mechanismsGene expressionDependent enhancersTranscriptionResponse elementResponsive enhancerNeural tubeCompetitive interactions
2001
A functional retinoic acid response element (RARE) is present within the distal promoter of the rat gonadotropin-releasing hormone (GnRH) gene
Cho S, Chung J, Choe Y, Choi H, Kim H, Rhee K, Kim K. A functional retinoic acid response element (RARE) is present within the distal promoter of the rat gonadotropin-releasing hormone (GnRH) gene. Brain Research 2001, 87: 204-213. PMID: 11245923, DOI: 10.1016/s0169-328x(01)00021-3.Peer-Reviewed Original ResearchConceptsGT1-1 cellsTrans-RARetinoic acid response elementConsensus retinoic acid response elementGT1-1 neuronal cellsRat GnRH geneGonadotropin-releasing hormone releaseFunctional retinoic acid response elementRat GnRH promoterGnRH promoterCAMP response elementGnRH transcriptionGnRH geneRat hypothalamic fragmentsSpecific bindingGonadotropin-releasing hormone (GnRH) geneTrans retinoic acidRARbeta gene expressionResponse elementAcid response elementHypothalamic fragmentsHormone releaseNeuronal cellsGene expressionPutative repeats
1998
Vitamin A Supplementation and Human Immunodeficiency Virus Load in Injection Drug Users
Semba R, Lyles C, Margolick J, Caiaffa W, Farzadegan H, Cohn S, Vlahov D. Vitamin A Supplementation and Human Immunodeficiency Virus Load in Injection Drug Users. The Journal Of Infectious Diseases 1998, 177: 611-616. PMID: 9498439, DOI: 10.1086/514235.Peer-Reviewed Original ResearchConceptsCD4 lymphocyte countHigh-dose vitaminHIV loadInjection drug usersLymphocyte countDrug usersVitamin AHuman immunodeficiency virus (HIV) infectionPlacebo-controlled clinical trialHuman immunodeficiency virus loadImmunodeficiency virus infectionUse of vitaminsPlasma vitaminHIV replicationVirus loadClinical trialsVirus infectionClinical investigationRetinol equivalentsSupplementationRetinoic acid response elementVitaminWeeksAcid response elementCount
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