2022
MR Imaging–Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver
Santana J, Petukhova-Greenstein A, Gross M, Hyder F, Pekurovsky V, Gottwald L, Boustani A, Walsh J, Kucukkaya A, Malpani R, Madoff D, Goldberg S, Ahmed M, Joshi N, Coman D, Chapiro J. MR Imaging–Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver. Journal Of Vascular And Interventional Radiology 2022, 34: 395-403.e5. PMID: 36423815, PMCID: PMC11042914, DOI: 10.1016/j.jvir.2022.11.013.Peer-Reviewed Original ResearchConceptsImmune responseT1-weighted MRPrussian blue stainingRadiofrequency ablationRF ablationC57BL/6 wild-type miceMR imagingDose-escalation studyLocal immune responseMass cytometryWild-type miceRadiological-pathological correlationBlue stainingT1-weighted MR imagingHepatic radiofrequency ablationCD68 antibodyUntreated lobeVivo doseHepatic RF ablationVivo macrophagesMacrophagesMiceMR imaging scannerCoagulation areaCD68
2008
Histopathologic and Immunohistochemical Features of Tissue Adherent to Multitined Electrodes after RF Ablation of Liver Malignancies Can Help Predict Local Tumor Progression: Initial Results
Sofocleous C, Nascimento R, Petrovic L, Klimstra D, Gonen M, Brown K, Brody L, Covey A, Thornton R, Fong Y, Solomon S, Schwartz L, DeMatteo R, Getrajdman G. Histopathologic and Immunohistochemical Features of Tissue Adherent to Multitined Electrodes after RF Ablation of Liver Malignancies Can Help Predict Local Tumor Progression: Initial Results. Radiology 2008, 249: 364-74. PMID: 18796687, DOI: 10.1148/radiol.2491071752.Peer-Reviewed Original ResearchConceptsLocal tumor progressionRF ablationKi-67Liver malignanciesTumor cellsImmunohistochemical featuresTumor progressionCoagulative necrosisPredictor of local tumor progressionTumors treated with RF ablationKi-67-positive tumor cellsMultivariate analysisPredicting local tumor progressionInstitutional review board waiverMean tumor sizeKaplan-Meier methodLog-rank testHepatic RF ablationLTP-freeMultitined electrodesMedian survivalTumor sizeTumors 3Treated tumorsExamination of tissues
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