2020
The N-glycome regulates the endothelial-to-hematopoietic transition
Kasper DM, Hintzen J, Wu Y, Ghersi JJ, Mandl HK, Salinas KE, Armero W, He Z, Sheng Y, Xie Y, Heindel DW, Park EJ, Sessa WC, Mahal LK, Lebrilla C, Hirschi KK, Nicoli S. The N-glycome regulates the endothelial-to-hematopoietic transition. Science 2020, 370: 1186-1191. PMID: 33273096, PMCID: PMC8312266, DOI: 10.1126/science.aaz2121.Peer-Reviewed Original ResearchMeSH KeywordsADAM10 ProteinAnimalsAnimals, Genetically Modifiedbeta-Galactoside alpha-2,3-SialyltransferaseCell LineageCell TransdifferentiationEndothelial CellsGenes, ReporterGlycomicsGlycoproteinsGlycosylationHematopoietic Stem CellsMannosyltransferasesMicroRNAsPolysaccharidesSialyltransferasesZebrafishConceptsHematopoietic transitionHemogenic endothelial cellsProtein N-glycosylationLymphoid-myeloid lineageN-glycomeDefinitive hematopoietic stemEndothelial cellsHematopoietic fateMiR-223Mutant defectsGlycan biosynthesisN-glycosylationMetalloprotease ADAM10Intrinsic regulatorN-glycoproteinsHematopoietic stemProgenitor cellsHigh mannoseMicroRNA-223CellsKey determinantMannosyltransferaseMutantsLineagesBiosynthesis
2012
NogoB receptor is essential for extraembryonic vascular development and protein glycosylation
Park E, Sessa W. NogoB receptor is essential for extraembryonic vascular development and protein glycosylation. The FASEB Journal 2012, 26: 607.5-607.5. DOI: 10.1096/fasebj.26.1_supplement.607.5.Peer-Reviewed Original ResearchExtraembryonic vascular developmentDehydrodolichyl diphosphate synthaseProtein glycosylationPeri-implantation embryonic lethalityVascular developmentMutant yolk sacsProtein N-glycosylationYolk sacCKO embryosMutant embryosUseful model systemNon-functional formEmbryonic lethalityDiphosphate synthaseExtraembryonic tissuesN-glycosylationProtein stabilityEndothelial cellsConditional knockout miceDevelopment defectsTube formationMutantsCKO mouse modelModel systemEmbyronic development
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