2025
Quantitative Glycan-Protein Cross-Linking Mass Spectrometry Using Enrichable Linkers Reveals Extensive Glycan-Mediated Protein Interaction Networks
Chen S, Xie Y, Alvarez M, Sheng Y, Bouchibti Y, Chang V, Lebrilla C. Quantitative Glycan-Protein Cross-Linking Mass Spectrometry Using Enrichable Linkers Reveals Extensive Glycan-Mediated Protein Interaction Networks. Analytical Chemistry 2025, 97: 1584-1593. PMID: 39805041, PMCID: PMC11780575, DOI: 10.1021/acs.analchem.4c04134.Peer-Reviewed Original ResearchConceptsProtein-protein interactionsProtein interaction networkCell surface glycansTerminal sialic acidAbundant membrane proteinProtein pairsCross-linking mass spectrometrySurface glycansAffinity purificationInteraction networkSialylated glycoformsMembrane proteinsLysine residuesProtein networkTarget proteinsSialic acidGlycansBiotin groupPolypeptide moietyProteinInteractomeExtensive interactionsCell membranePeptide pairsPolypeptide
2024
Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model
Bukhari H, Nithianadam V, Battaglia R, Cicalo A, Sarkar S, Comjean A, Hu Y, Leventhal M, Dong X, Feany M. Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model. Genome Research 2024, 34: gr.278576.123. PMID: 38599684, PMCID: PMC11146598, DOI: 10.1101/gr.278576.123.Peer-Reviewed Original ResearchConceptsGenetic contextNon-cell-autonomous regulationMicrotubule-associated protein tauHuman diseasesGlial-neuronal signalingGene regulatory programsKnock-in fliesTau P301L mutationFrontotemporal dementiaProtein interaction networkModel of tauopathyAge-dependent neurodegenerationSingle-cell RNA sequencingCell signaling pathwaysExperimental model organismAccumulate DNA damageModel of frontotemporal dementiaAutosomal dominant formSingle-cell sequencing analysisPathways of neurotoxicityProtein tauP301L mutationTauopathy modelNeuronal cell typesSequence analysis
2023
S1324 Gender Disparity in Hepatocellular Carcinoma Survival: Exploiting Tissue-Specific Protein Interaction Networks to Unveil Prognostic Gene Modules
Fozo L, Njei B. S1324 Gender Disparity in Hepatocellular Carcinoma Survival: Exploiting Tissue-Specific Protein Interaction Networks to Unveil Prognostic Gene Modules. The American Journal Of Gastroenterology 2023, 118: s1012-s1013. DOI: 10.14309/01.ajg.0000954936.07320.e4.Peer-Reviewed Original ResearchProtein interaction networkInteraction networkGene modulesPrognostic gene modulesHepatocellular carcinoma survivalGender disparities
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