Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model
Bukhari H, Nithianadam V, Battaglia R, Cicalo A, Sarkar S, Comjean A, Hu Y, Leventhal M, Dong X, Feany M. Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model. Genome Research 2024, 34: gr.278576.123. PMID: 38599684, PMCID: PMC11146598, DOI: 10.1101/gr.278576.123.Peer-Reviewed Original ResearchConceptsGenetic contextNon-cell-autonomous regulationMicrotubule-associated protein tauHuman diseasesGlial-neuronal signalingGene regulatory programsKnock-in fliesTau P301L mutationFrontotemporal dementiaProtein interaction networkModel of tauopathyAge-dependent neurodegenerationSingle-cell RNA sequencingCell signaling pathwaysExperimental model organismAccumulate DNA damageModel of frontotemporal dementiaAutosomal dominant formSingle-cell sequencing analysisPathways of neurotoxicityProtein tauP301L mutationTauopathy modelNeuronal cell typesSequence analysis
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