2020
Alterations in Ki67 Labeling Following Treatment of Poorly Differentiated Neuroendocrine Carcinomas
Vyas M, Tang L, Rekhtman N, Klimstra D. Alterations in Ki67 Labeling Following Treatment of Poorly Differentiated Neuroendocrine Carcinomas. The American Journal Of Surgical Pathology 2020, 45: 25-34. PMID: 33177340, PMCID: PMC8549487, DOI: 10.1097/pas.0000000000001602.Peer-Reviewed Original ResearchConceptsHigh-grade neuroendocrine neoplasmsWD-NETsKi67 indexPD-NECsPoor-differentiated neuroendocrine carcinomasWell-differentiated neuroendocrine tumorsTreatment-associated alterationsSemi-quantitative scoreLow Ki67WHO G1Neuroendocrine carcinomaAdenoneuroendocrine carcinomaNeuroendocrine tumorsNeuroendocrine neoplasmsPrognostic significanceG2 gradeKi67 labelingDiagnostic pitfallsWHO gradePosttreatment groupStudy cohortAnatomical sitesKi67Pretreatment groupPosttreatment samples
2012
Objective Quantification of the Ki67 Proliferative Index in Neuroendocrine Tumors of the Gastroenteropancreatic System
Tang L, Gonen M, Hedvat C, Modlin I, Klimstra D. Objective Quantification of the Ki67 Proliferative Index in Neuroendocrine Tumors of the Gastroenteropancreatic System. The American Journal Of Surgical Pathology 2012, 36: 1761-1770. PMID: 23026928, DOI: 10.1097/pas.0b013e318263207c.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCell ProliferationClinical CompetenceClinical Laboratory TechniquesHumansImage Processing, Computer-AssistedImmunohistochemistryIntestinal NeoplasmsIntestine, SmallKi-67 AntigenNeoplasm GradingNeuroendocrine TumorsObserver VariationPancreatic NeoplasmsPredictive Value of TestsPrognosisRectal NeoplasmsReproducibility of ResultsConceptsNeuroendocrine tumorsKi67 assessmentWorld Health OrganizationGold standardProliferative rateTumor cell proliferative rateDetermination of therapeutic strategyGrade neuroendocrine tumorsKi67 labeling indexIntraclass correlationKi67 proliferative indexDetermination of prognosisDigital image analysisIntraobserver consistencyCell proliferative rateKi67 percentageGroup tumorsKi67 scoreTumor gradeKi67 indexPrognostic stratificationProliferative indexClinicopathological characteristicsKi67 labelingLabeling index
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