HSPA2 influences the differentiation and production of immunomodulatory mediators in human immortalized epidermal keratinocyte lines
Gogler A, Wilk A, Sojka D, Adamiec-Organiściok M, Matysiak N, Kania D, Wiecha K, Małusecka E, Cortez A, Zamojski D, Marczyk M, Mazurek A, Oziębło S, Scieglinska D. HSPA2 influences the differentiation and production of immunomodulatory mediators in human immortalized epidermal keratinocyte lines. Cell Death & Disease 2025, 16: 344. PMID: 40287440, PMCID: PMC12033329, DOI: 10.1038/s41419-025-07565-5.Peer-Reviewed Original ResearchConceptsChaperone proteinsKeratinocyte differentiationCell type-specific expression patternsHomologous chaperone proteinsEpidermal keratinocyte differentiationInterferon-mediated signalingInterferon-stimulated genesControl proteostasisExtracellular secretionTranscriptome analysisMolecular machineryKeratinocyte differentiation markersHSPA2Upper epidermal layersDifferentiation defectsExpression patternsSomatic cellsMolecular networksPro-inflammatory IL-6 cytokinePotential therapeutic targetFunctional analysisSecretion of IL-6Keratinocyte linePathogenic factorsReduced levels
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