2025
HSPA2 influences the differentiation and production of immunomodulatory mediators in human immortalized epidermal keratinocyte lines
Gogler A, Wilk A, Sojka D, Adamiec-Organiściok M, Matysiak N, Kania D, Wiecha K, Małusecka E, Cortez A, Zamojski D, Marczyk M, Mazurek A, Oziębło S, Scieglinska D. HSPA2 influences the differentiation and production of immunomodulatory mediators in human immortalized epidermal keratinocyte lines. Cell Death & Disease 2025, 16: 344. PMID: 40287440, PMCID: PMC12033329, DOI: 10.1038/s41419-025-07565-5.Peer-Reviewed Original ResearchConceptsChaperone proteinsKeratinocyte differentiationCell type-specific expression patternsHomologous chaperone proteinsEpidermal keratinocyte differentiationInterferon-mediated signalingInterferon-stimulated genesControl proteostasisExtracellular secretionTranscriptome analysisMolecular machineryKeratinocyte differentiation markersHSPA2Upper epidermal layersDifferentiation defectsExpression patternsSomatic cellsMolecular networksPro-inflammatory IL-6 cytokinePotential therapeutic targetFunctional analysisSecretion of IL-6Keratinocyte linePathogenic factorsReduced levels
1990
Susceptibility of human cells to killing by the parvoviruses H-1 and minute virus of mice correlates with viral transcription
Cornelis J, Chen Y, Spruyt N, Duponchel N, Cotmore S, Tattersall P, Rommelaere J. Susceptibility of human cells to killing by the parvoviruses H-1 and minute virus of mice correlates with viral transcription. Journal Of Virology 1990, 64: 2537-2544. PMID: 2139892, PMCID: PMC249429, DOI: 10.1128/jvi.64.6.2537-2544.1990.Peer-Reviewed Original ResearchConceptsViral mRNAsHuman cellsLevel of transcriptionMinute virusMajor viral transcriptViral DNA amplificationNonstructural polypeptidesGene productsOncogenic transformationGene expressionIntracellular localizationNonstructural proteinsViral transcriptionViral transcriptsTranscriptionViral genomeParvovirus HCell susceptibilityHuman fibroblastsVirus uptakeEpithelial cellsDNA amplificationResistant derivativesKeratinocyte lineDifferential susceptibility
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