2024
Potential Association of Blood Transfusion in Deceased Donors With Outcomes of Liver Transplantation in the United States
Okumura K, Dhand A, Misawa R, Sogawa H, Veillette G, Nishida S. Potential Association of Blood Transfusion in Deceased Donors With Outcomes of Liver Transplantation in the United States. Journal Of Surgical Research 2024, 300: 477-484. PMID: 38875946, DOI: 10.1016/j.jss.2024.05.025.Peer-Reviewed Original ResearchConceptsDonor blood transfusionIncreased risk of rejectionMultivariate Cox hazard modelOutcome of liver transplantationBlood transfusionRisk of rejectionLiver transplantationCox hazard modelLT recipientsTransfusion donorIncreased riskAssociation of blood transfusionUnited Network for Organ Sharing databaseBlood transfusion donorsRecipients of LTKaplan-Meier methodPost-transplant graftOverall immune suppressionBrain death donorsNo transfusionsOverall survivalPost-LTImmune suppressionGraft failureAdult recipients
2023
The local microenvironment drives activation of neutrophils in human brain tumors
Maas R, Soukup K, Fournier N, Massara M, Galland S, Kornete M, Wischnewski V, Lourenco J, Croci D, Álvarez-Prado Á, Marie D, Lilja J, Marcone R, Calvo G, Santalla Mendez R, Aubel P, Bejarano L, Wirapati P, Ballesteros I, Hidalgo A, Hottinger A, Brouland J, Daniel R, Hegi M, Joyce J. The local microenvironment drives activation of neutrophils in human brain tumors. Cell 2023, 186: 4546-4566.e27. PMID: 37769657, DOI: 10.1016/j.cell.2023.08.043.Peer-Reviewed Original ResearchTumor-associated neutrophilsHuman brain tumorsBrain tumorsTumor necrosis factor alphaDistinct inflammatory signatureOverall immune suppressionBrain metastasis patientsPro-inflammatory mediatorsSoluble inflammatory mediatorsAbundant immune cellsNecrosis factor alphaActivation of neutrophilsTumor-associated macrophagesPro-angiogenic capacityBrain metastasesInflammatory signatureMetastasis patientsInflammatory mediatorsNeutrophil phenotypeImmune suppressionPeripheral bloodBlood neutrophilsDifferent cancer typesImmune cellsBrain microenvironment
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