2024
Closed-loop microstimulations of the orbitofrontal cortex during real-life gaze interaction enhance dynamic social attention
Fan S, Dal Monte O, Nair A, Fagan N, Chang S. Closed-loop microstimulations of the orbitofrontal cortex during real-life gaze interaction enhance dynamic social attention. Neuron 2024, 112: 2631-2644.e6. PMID: 38823391, PMCID: PMC11309918, DOI: 10.1016/j.neuron.2024.05.004.Peer-Reviewed Original ResearchPrimate prefrontal cortexPrefrontal cortexSocial attentionOrbitofrontal cortexDorsomedial prefrontal cortexAnterior cingulate cortexCingulate cortexDirect gazeGaze interactionCortexGaze dynamicsControl different aspectsDistance of fixationDifferent aspectsGaze eventsPartner eyeGazeMultiple regionsMicrostimulationGaze positionAttentionSpatial dimensionsLatencyNeurons
2020
Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex
Galvin VC, Yang ST, Paspalas CD, Yang Y, Jin LE, Datta D, Morozov YM, Lightbourne TC, Lowet AS, Rakic P, Arnsten AFT, Wang M. Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex. Neuron 2020, 106: 649-661.e4. PMID: 32197063, PMCID: PMC7244366, DOI: 10.1016/j.neuron.2020.02.030.Peer-Reviewed Original ResearchConceptsKCNQ channelsInverted-U dose responseCell firingPrefrontal cortexMuscarinic M1 receptorsKCNQ potassium channelsSingle-unit recordingsPrimate prefrontal cortexDorsolateral prefrontal cortexCholinergic alterationsKCNQ isoformsM1 receptorsPyramidal neuronsCholinergic depletionMuscarinic M1Cognitive disordersAged monkeysPersistent firingRecurrent excitationPotassium channelsAppropriate targetsDose responseM1R stimulationSensory inputCortex
2015
Dopamine’s Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders
Arnsten AF, Wang M, Paspalas CD, Witkin J. Dopamine’s Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders. Pharmacological Reviews 2015, 67: 681-696. PMID: 26106146, PMCID: PMC4485014, DOI: 10.1124/pr.115.010512.Peer-Reviewed Original ResearchConceptsCell firingPyramidal cell dendritesD2 receptor familyFrontal eye fieldPrimate prefrontal cortexGABA interneuronsCortical dopamineDopamine actionGlutamate releaseEndogenous dopamineDA cellsCell dendritesD1R agonistDendritic spinesCognitive disordersOrbital PFCEye fieldPositive symptomsLikely projectResponse cellsCognitive deficitsPrefrontal cortexStimulation speedFeedback neuronsD1R
2009
5.3 Dopamine’s Influence on Prefrontal Cortical Cognition: Actions and Circuits in Behaving Primates
Arnsten A, Vijayraghavan S, Wang M, Gamo N, Paspalas C. 5.3 Dopamine’s Influence on Prefrontal Cortical Cognition: Actions and Circuits in Behaving Primates. 2009, 230-248. DOI: 10.1093/acprof:oso/9780195373035.003.0016.Peer-Reviewed Original Research
1999
Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys
Jentsch J, Taylor J, Redmond Jr D, Elsworth J, Youngren K, Roth R. Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys. Psychopharmacology 1999, 142: 78-84. PMID: 10102786, DOI: 10.1007/s002130050865.Peer-Reviewed Original ResearchConceptsFrontostriatal systemCognitive functionPrefrontal cortexObject retrieval taskRegulation of cognitionPrimate prefrontal cortexD4 dopamine receptorsNormal control monkeysDR antagonistsCognitive processesDetour taskCognitive deficitsPerformance impairmentBrain regionsCognitive dysfunctionRetrieval tasksFrontal cortexTaskCortexCortical dopaminergicDeficitsDopaminergic systemAntagonist reversalControl subjectsDopamine receptors
1997
Down-Regulation of the D1 and D5 Dopamine Receptors in the Primate Prefrontal Cortex by Chronic Treatment with Antipsychotic Drugs 1
Lidow M, Elsworth J, Goldman-Rakic P. Down-Regulation of the D1 and D5 Dopamine Receptors in the Primate Prefrontal Cortex by Chronic Treatment with Antipsychotic Drugs 1. Journal Of Pharmacology And Experimental Therapeutics 1997, 281: 597-603. PMID: 9103549, DOI: 10.1016/s0022-3565(24)36627-3.Peer-Reviewed Original ResearchConceptsChronic treatmentAntipsychotic drugsPrefrontal cortexReceptor antagonismDopamine receptorsD5 dopamine receptor mRNAD2 dopamine receptor antagonismD2 receptor antagonismDopamine receptor mRNAVehicle control groupTreatment of schizophreniaD1 classD5 dopamine receptorsDopamine receptor antagonismPrimate prefrontal cortexD5 mRNAsDopaminergic receptorsAntipsychotic medicationAntipsychotic efficacyD2 antagonistTherapeutic rangeAntipsychotic activityPharmacological spectrumReceptor mRNARibonuclease protection assays
1991
Prenatal specification of callosal connections in rhesus monkey
Schwartz M, Goldman‐Rakic P. Prenatal specification of callosal connections in rhesus monkey. The Journal Of Comparative Neurology 1991, 307: 144-162. PMID: 1713225, DOI: 10.1002/cne.903070113.Peer-Reviewed Original ResearchConceptsCallosal neuronsLayer IIIPrefrontal cortexInjection siteHeterotopic areasCortical layersCallosal projection neuronsLateral orbital cortexLayer III neuronsPrimate prefrontal cortexPattern of maturationMonkey prefrontal cortexDorsolateral prefrontal cortexLarge injection sitesHomotopic cortexOpposite hemisphereCallosal connectionsAdult casesProjection neuronsRetrograde tracerCallosal axonsOrbital cortexComparable injectionsFrontal cortexAdult monkeys
1989
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi S, Bruce C, Goldman-Rakic P. Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. Journal Of Neurophysiology 1989, 61: 331-349. PMID: 2918358, DOI: 10.1152/jn.1989.61.2.331.Peer-Reviewed Original ResearchConceptsDelay-period activityDorsolateral prefrontal cortexPS neuronsPrefrontal cortexPrincipal sulcusDirectional delay-period activityMonkey dorsolateral prefrontal cortexSpontaneous rateFrontal eye field regionOculomotor delayed-response taskSpatial memory functionPeriod activityCue directionSaccadic eye movementsOculomotor behaviorPrimate prefrontal cortexSubsequent delay periodTask-related activityVisual field locationsExcitatory responsesMost neuronsAnterior bankArcuate sulcusInhibitory responsesFixation target
1988
Periodicity of GABA-containing cells in primate prefrontal cortex
Schwartz M, Zheng D, Goldman-Rakic P. Periodicity of GABA-containing cells in primate prefrontal cortex. Journal Of Neuroscience 1988, 8: 1962-1970. PMID: 3385485, PMCID: PMC6569329, DOI: 10.1523/jneurosci.08-06-01962.1988.Peer-Reviewed Original ResearchConceptsPrincipal sulcusInhibitory local circuit neuronsLocal circuit neuronsPrimate prefrontal cortexColumns of neuronsCommon physiological propertiesCircuit neuronsGABA cellsImmunoreactive cellsSensory cortexFrontal lobeMacaque monkeysPrefrontal cortexCortexGABATangential distributionNeuronsSulcusCellsPhysiological propertiesCell dispositionAfferentsFindingsFirst indicationGapless series
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