2021
Preclinical characterization of [18F]T-008, a novel PET imaging radioligand for cholesterol 24-hydroxylase
Koike T, Constantinescu CC, Ikeda S, Nishi T, Sunahara E, Miyamoto M, Cole P, Barret O, Alagille D, Papin C, Morley T, Fowles K, Seibyl J, Tamagnan G, Kuroita T. Preclinical characterization of [18F]T-008, a novel PET imaging radioligand for cholesterol 24-hydroxylase. European Journal Of Nuclear Medicine And Molecular Imaging 2021, 49: 1148-1156. PMID: 34651220, PMCID: PMC8921165, DOI: 10.1007/s00259-021-05565-z.Peer-Reviewed Original ResearchConceptsBrain sectionsMouse brain sectionsEnzyme occupancyBrain-specific enzymeBrain cholesterol homeostasisTreatment of seizuresWild-type miceAdult rhesus macaquesDose-dependent mannerWarrants further studyLogan graphical analysisEpileptic encephalopathySoticlestatBaseline scanAutoradiography studiesPreclinical characterizationLassen plotPreclinical validationBrain regionsCortical regionsPET studiesRhesus macaquesCholesterol homeostasisPET imagingARG study
2020
Preclinical Validation of a Single-Scan Rest/Stress Imaging Technique for 13N-Ammonia Positron Emission Tomography Cardiac Perfusion Studies
Guehl N, Pelletier-Galarneau M, Wooten D, Guerrero J, Kas A, Normandin M, Fakhri G, Alpert N. Preclinical Validation of a Single-Scan Rest/Stress Imaging Technique for 13N-Ammonia Positron Emission Tomography Cardiac Perfusion Studies. Circulation Cardiovascular Imaging 2020, 13: e009407. PMID: 31959009, PMCID: PMC7205554, DOI: 10.1161/circimaging.119.009407.Peer-Reviewed Original ResearchConceptsMyocardial blood flowPerfusion imagingMyocardial perfusion imaging proceduresSCAN-ALeft anterior descending arteryDose of adenosineAbsolute myocardial blood flowStress perfusion imagingAnterior descending arteryCardiac perfusion studiesMyocardial blood flow measurementsBland-Altman analysisNonstationary kinetic modelPositron emission tomographyMeasurement of restMyocardial blood flow valuesPharmacological stressorDescending arteryPreclinical validationMyocardial blood flow estimatesSingle-scan acquisitionPerfusion studiesVariable dosesImaging sessionMicrosphere MBF measurements
2015
Advancing the Minimal Residual Disease Concept in Acute Myeloid Leukemia
Hokland P, Ommen H, Mulé M, Hourigan C. Advancing the Minimal Residual Disease Concept in Acute Myeloid Leukemia. Seminars In Hematology 2015, 52: 184-192. PMID: 26111465, PMCID: PMC4484880, DOI: 10.1053/j.seminhematol.2015.04.001.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaMyeloid leukemiaNon-acute promyelocytic leukemiaAcute myeloid leukemia patientsResidual disease burdenResponse to treatmentPersonalized treatment plansMRD measurementsClinical relapseClinical decision-makingPreclinical validationNon-APLTreatment planningPromyelocytic leukemiaLeukemiaMRDCurrent patient statusPatientsDisease burdenLaboratory investigationsPatient statusNatural hesitancyAssay sensitivityDrug developmentSensitive tool
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