2022
Biomarkers of ketamine's antidepressant effect: An umbrella review
Meshkat S, Ho R, Cao B, Teopiz K, Rosenblat J, Rhee T, Di Vincenzo J, Ceban F, Jawad M, McIntyre R. Biomarkers of ketamine's antidepressant effect: An umbrella review. Journal Of Affective Disorders 2022, 323: 598-606. PMID: 36521662, DOI: 10.1016/j.jad.2022.12.021.Peer-Reviewed Original ResearchConceptsKetamine's antidepressant effectsAntidepressant effectsUmbrella reviewMajor depressive disorder (MDD) pathogenesisRapid acting antidepressant (RAAD) effectsMechanistically relevant biomarkersPotential peripheral biomarkerTreatment-resistant patientsAnti-inflammatory effectsNMDA receptor antagonistReal-world populationTreatment response predictionInflammatory markersPeripheral biomarkersKetamine actionReceptor antagonistSymptom deteriorationClinical utilityNeuroimaging biomarkersDisorder pathogenesisSynaptic plasticityCingulate cortexSystematic reviewKetamineFunctional connectivity
2012
Translocator Protein 18 kDa (TSPO) Expression in Multiple Sclerosis Patients
Harberts E, Datta D, Chen S, Wohler J, Oh U, Jacobson S. Translocator Protein 18 kDa (TSPO) Expression in Multiple Sclerosis Patients. Journal Of Neuroimmune Pharmacology 2012, 8: 51-57. PMID: 22956240, PMCID: PMC4765953, DOI: 10.1007/s11481-012-9397-5.Peer-Reviewed Original ResearchMeSH KeywordsAcetamidesAdultBiomarkersBrainCell SeparationFemaleHumansIsoquinolinesLeukocytes, MononuclearLipopolysaccharide ReceptorsMagnetic Resonance ImagingMaleMembrane Potential, MitochondrialMiddle AgedMitochondriaMultiple SclerosisPositron-Emission TomographyProtein BindingPyridinesRadioligand AssayRadiopharmaceuticalsReal-Time Polymerase Chain ReactionReceptors, GABAConceptsPeripheral blood mononuclear cellsMultiple sclerosis patientsExpression of TSPOMagnetic resonance imagingPositron emission tomographyTSPO expressionSclerosis patientsCentral nervous system inflammationHealthy donor cohortNervous system inflammationMarkers of inflammationPotential peripheral biomarkerBlood mononuclear cellsTranslocator protein 18TSPO protein expressionSystem inflammationMS patientsNeuroinflammatory conditionsPeripheral biomarkersMononuclear cellsNeuropathologic conditionsDonor cohortInflammatory diseasesHealthy donorsHealthy individuals
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