2017
Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication
Wang Y, Lee S, Ha Y, Lam W, Chen SR, Dutschman GE, Gullen EA, Grill SP, Cheng Y, Fürstner A, Francis S, Baker DC, Yang X, Lee KH, Cheng YC. Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication. Scientific Reports 2017, 7: 10037. PMID: 28855547, PMCID: PMC5577180, DOI: 10.1038/s41598-017-08815-z.Peer-Reviewed Original ResearchConceptsHepatitis C virus replicationC virus replicationTylophorine analogsHCV replicationHeat shock cognate protein 70HCV RNAShock cognate protein 70Inhibits Hepatitis C Virus ReplicationVirus replicationProtein 70Anti-HCV activityHCV replication complexPotent inhibitory activityExhibit potent inhibitory activityInhibitory activityATPase activityArthritisInflammationLupusReplicationActivityCancerHsc70
1996
Inhibition of Epstein-Barr virus replication by a novel l-nucleoside, 2′-fluoro-5-methyl-β-l-arabinofuranosyluracil
Yao G, Liu S, Chou E, Kukhanova M, Chu C, Cheng Y. Inhibition of Epstein-Barr virus replication by a novel l-nucleoside, 2′-fluoro-5-methyl-β-l-arabinofuranosyluracil. Biochemical Pharmacology 1996, 51: 941-947. PMID: 8651944, DOI: 10.1016/0006-2952(96)00049-4.Peer-Reviewed Original ResearchConceptsEpstein-Barr virus replicationL-FMAUNovel L-nucleoside analogVirus replicationEBV DNA polymeraseMechanism of actionL-nucleoside analoguesEBV agentsPotent inhibitory activityAntiviral activityEBVVirus productionInhibitory concentrationViral productionHuman DNA polymerase alphaSelective inhibitorViral DNAInhibitory activityMetabolism studiesCell growthCellsInhibitionDNA polymerase alphaCellular DNANon-producing cells
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