2021
Use of tranexamic acid does not influence perioperative outcomes in ambulatory foot and ankle surgery—a prospective triple blinded randomized controlled trial
B.H P, Diskina D, Lin H, Vulcano E, Lai Y. Use of tranexamic acid does not influence perioperative outcomes in ambulatory foot and ankle surgery—a prospective triple blinded randomized controlled trial. International Orthopaedics 2021, 45: 2277-2284. PMID: 34324042, DOI: 10.1007/s00264-021-05131-0.Peer-Reviewed Original ResearchConceptsIntra-operative blood lossAnkle surgeryBlood lossRandomized Controlled TrialsPlacebo groupMorphine milliequivalentsOpioid consumptionTXA groupPerioperative outcomesWound complicationsAmbulatory footAcademic health centresIncidence of wound complicationsPost-operative painPerioperative blood lossPost-operative dayAmbulatory surgical populationInfluence perioperative outcomesMeasurementsPrimary outcomeHealth centresAnkle proceduresAnkleTXA useAntifibrinolytic medicationTranexamic acid
2020
Perioperative methadone prescribing and association with respiratory depression.
Bova S, Kruer R, Nesbit S, Grant M, Jarrell A. Perioperative methadone prescribing and association with respiratory depression. Journal Of Opioid Management 2020, 16: 443-449. PMID: 33428191, DOI: 10.5055/jom.2020.0602.Peer-Reviewed Original ResearchConceptsPercent of patientsRespiratory depressionMethadone useMethadone initiationMethadone dosingRisk factorsPost-operative respiratory depressionAcute post-operative painSingle academic medical centerInadequate pain controlPost-operative painPost-operative dayAcademic medical centerAnalgesia managementChronic opioidsPain controlAdult patientsBaseline characteristicsCohort studyMost patientsSurgery patientsAdult inpatientsSingle centerMale sexMedical records
2017
The role of extracorporeal membrane oxygenator therapy in the setting of Type A aortic dissection
Sultan I, Habertheuer A, Wallen T, Siki M, Szeto W, Bavaria JE, Williams M, Vallabhajosyula P. The role of extracorporeal membrane oxygenator therapy in the setting of Type A aortic dissection. Journal Of Cardiac Surgery 2017, 32: 822-825. PMID: 29216679, DOI: 10.1111/jocs.13245.Peer-Reviewed Original ResearchConceptsPost-operative dayAortic dissectionTAAD repairECMO supportPennsylvania Health Care Cost Containment Council databaseDiagnosis/procedure codesType A Aortic DissectionFirst post-operative dayAcute cardiopulmonary failurePost-cardiotomy shockSame hospital visitA Aortic DissectionAcute aortic dissectionSame dayWide clinical spectrumSalvage therapyTAAD surgeryECMO implantationCardiopulmonary failureHemodynamic stabilityCardiovascular collapseOpen repairOverall mortalityMedian timeClinical spectrum
2015
Association of Perioperative Plasma Neutrophil Gelatinase-Associated Lipocalin Levels with 3-Year Mortality after Cardiac Surgery: A Prospective Observational Cohort Study
Moledina DG, Parikh CR, Garg AX, Thiessen-Philbrook H, Koyner JL, Patel UD, Devarajan P, Shlipak MG, Coca SG. Association of Perioperative Plasma Neutrophil Gelatinase-Associated Lipocalin Levels with 3-Year Mortality after Cardiac Surgery: A Prospective Observational Cohort Study. PLOS ONE 2015, 10: e0129619. PMID: 26053382, PMCID: PMC4460181, DOI: 10.1371/journal.pone.0129619.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAcute-Phase ProteinsAgedAged, 80 and overBiomarkersCardiac Surgical ProceduresCause of DeathCohort StudiesCreatinineFemaleFollow-Up StudiesHumansKidney Function TestsLipocalin-2LipocalinsMaleMiddle AgedMortalityPerioperative PeriodProspective StudiesProto-Oncogene ProteinsRisk FactorsTime FactorsConceptsPlasma neutrophil gelatinase-associated lipocalinProspective observational cohort studyLong-term mortalityObservational cohort studySerum creatinineCardiac surgeryCohort studyIndependent associationPlasma neutrophil gelatinase associated lipocalin (NGAL) levelsNeutrophil Gelatinase-Associated Lipocalin LevelsShort-term adverse outcomesNeutrophil Gelatinase-Associated LipocalinAcute kidney injuryPre-operative variablesIntra-operative variablesGelatinase-Associated LipocalinGlomerular filtration ratePre-operative levelsPeri-operative changesPost-operative dayTRIBE-AKI cohortLipocalin levelsCause mortalityKidney injuryNGAL levels
2002
The effect of castration on endothelins, their receptors and endothelin converting enzyme in rat prostate
Takahashi W, Afiatpour P, Foster H, Ikeda K, Wada Y, Weiss RM, Latifpour J. The effect of castration on endothelins, their receptors and endothelin converting enzyme in rat prostate. Naunyn-Schmiedeberg's Archives Of Pharmacology 2002, 366: 166-176. PMID: 12122504, DOI: 10.1007/s00210-002-0575-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAspartic Acid EndopeptidasesAutoradiographyDiabetes Mellitus, ExperimentalDNA PrimersEndothelin-1Endothelin-3Endothelin-Converting EnzymesGene ExpressionMaleMetalloendopeptidasesMicroscopyOrchiectomyOrgan SizeProstateProtein BindingRadioligand AssayRatsRats, Sprague-DawleyReceptor, Endothelin AReceptor, Endothelin BReceptors, EndothelinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerConceptsReceptor subtype mRNAsET receptor subtypesSerum testosterone levelsET receptorsRat prostateEffects of castrationReceptor subtypesSubtype mRNAsDorsolateral regionTestosterone levelsET-1Three-month-old SpraguePharmacological propertiesDiabetes-induced reductionET receptor systemET-3 mRNAETB receptor subtypesPost-operative dayReverse transcription-polymerase chain reactionVentral regionECE-1 mRNATranscription-polymerase chain reactionLight microscopy autoradiographyEnzyme-1 mRNAMultiplex reverse transcription-polymerase chain reaction
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