2013
IMPACT OF POINT–OF–CARE PLATELET FUNCTION TESTING AMONG PATIENTS WITH AND WITHOUT ACUTE CORONARY SYNDROMES UNDERGOING PCI WITH DRUG–ELUTING STENTS: AN ADAPT–DES SUBSTUDY
Rinaldi M, Kirtane A, Xu K, Witzenbichler B, Weisz G, Neumann F, Metzger C, Henry T, Cox D, Duffy P, Brodie B, Stuckey T, Mazzaferri E, Cristea E, Parise H, Mehran R, Stone G. IMPACT OF POINT–OF–CARE PLATELET FUNCTION TESTING AMONG PATIENTS WITH AND WITHOUT ACUTE CORONARY SYNDROMES UNDERGOING PCI WITH DRUG–ELUTING STENTS: AN ADAPT–DES SUBSTUDY. Journal Of The American College Of Cardiology 2013, 61: e1857. DOI: 10.1016/s0735-1097(13)61857-4.Peer-Reviewed Original ResearchP2Y12 Receptor Inhibitors in Acute Coronary Syndromes: What Is New on the Horizon?
Oprea AD, Popescu WM. P2Y12 Receptor Inhibitors in Acute Coronary Syndromes: What Is New on the Horizon? Cardiology Research And Practice 2013, 2013: 195456. PMID: 23533940, PMCID: PMC3590496, DOI: 10.1155/2013/195456.Peer-Reviewed Original ResearchAcute coronary syndromeP2Y12 receptor inhibitorsPercutaneous coronary interventionPlatelet function testingCoronary syndromeReceptor inhibitorsAntiplatelet therapyCoronary interventionFunction testingDual antiplatelet therapySubsequent ischemic eventsHigh-risk patientsEffective antiplatelet agentCornerstone therapyIschemic eventsAntiplatelet agentsPharmacodynamic interactionsPlatelet inhibitionPercutaneous interventionPharmacogenomic factorsPlatelet functionCare assaysRoutine usePatientsSyndromeEvaluating the clinical usefulness of platelet function testing: Considerations for the proper application and interpretation of performance measures
Dahlen J, Price M, Parise H, Gurbel P. Evaluating the clinical usefulness of platelet function testing: Considerations for the proper application and interpretation of performance measures. Thrombosis And Haemostasis 2013, 109: 808-816. PMID: 23254993, DOI: 10.1160/th12-08-0608.Peer-Reviewed Original ResearchConceptsPlatelet function testingFunction testingClinical usefulnessP2Y12 inhibitorsPharmacodynamic effectsPredictive valueFuture thrombotic eventsRate of thrombosisManagement of patientsPlatelet function testsNet reclassification improvementDiagnostic performance indicatorsPlatelet P2Y12 receptorPositive predictive valueDiagnostic performance measuresCardiovascular eventsHazard ratioThrombotic eventsRisk stratificationFunction testsPrognostic utilityAntiplatelet effectReclassification improvementRisk factorsP2Y12 receptor
2012
IMPACT OF POINT-OF-CARE PLATELET FUNCTION TESTING AMONG PATIENTS WITH AND WITHOUT ACUTE CORONARY SYNDROMES UNDERGOING PCI WITH DRUG-ELUTING STENTS: AN ADAPT-DES SUBSTUDY
Kirtane A, Rinaldi M, Parise H, Witzenbichler B, Weisz G, Neumann F, Metzger D, Henry T, Cox D, Duffy P, Brodie B, Stuckey T, Mazzaferri E, Cristea E, Mehran R, Stone G. IMPACT OF POINT-OF-CARE PLATELET FUNCTION TESTING AMONG PATIENTS WITH AND WITHOUT ACUTE CORONARY SYNDROMES UNDERGOING PCI WITH DRUG-ELUTING STENTS: AN ADAPT-DES SUBSTUDY. Journal Of The American College Of Cardiology 2012, 59: e291. DOI: 10.1016/s0735-1097(12)60292-7.Peer-Reviewed Original ResearchIMPACT OF POINT-OF-CARE PLATELET FUNCTION TESTING AMONG DIABETIC AND NON-DIABETIC PATIENTS UNDERGOING PCI WITH DRUG-ELUTING STENTS: AN ADAPT-DES SUBSTUDY
Kirtane A, Stuckey T, Parise H, Witzenbichler B, Weisz G, Rinaldi M, Neumann F, Metzger D, Henry T, Cox D, Duffy P, Brodie B, Mazzaferri E, Cristea E, Mehran R, Stone G. IMPACT OF POINT-OF-CARE PLATELET FUNCTION TESTING AMONG DIABETIC AND NON-DIABETIC PATIENTS UNDERGOING PCI WITH DRUG-ELUTING STENTS: AN ADAPT-DES SUBSTUDY. Journal Of The American College Of Cardiology 2012, 59: e268. DOI: 10.1016/s0735-1097(12)60269-1.Peer-Reviewed Original Research
2009
Platelet-Related Bleeding: An Update on Diagnostic Modalities and Therapeutic Options
Peddinghaus ME, Tormey CA. Platelet-Related Bleeding: An Update on Diagnostic Modalities and Therapeutic Options. Clinics In Laboratory Medicine 2009, 29: 175-191. PMID: 19665674, DOI: 10.1016/j.cll.2009.03.004.Peer-Reviewed Original ResearchConceptsPlatelet function testingFunction testingCare platelet function testingChronic clinical settingsPlatelet-related bleedingLife-threatening problemTransfusion strategyPlatelet dysfunctionTherapeutic optionsComponent therapyDiagnostic modalitiesClinical settingBleedingPatientsInitial studyLaboratory assaysTransfusionDysfunctionTherapyCare
1998
Platelet function testing by flow cytometry.
Rinder H. Platelet function testing by flow cytometry. Clinical Laboratory Science 1998, 11: 365-72. PMID: 10345505.Peer-Reviewed Original ResearchConceptsFlow cytometryPlatelet functionEx vivo platelet functionVivo platelet functionPlatelet function testingIntracellular calcium fluxExposure of plateletsPlatelet glycoprotein receptorsFluorescent monoclonal antibodiesFunction testingPlatelet aggregationActivation statusCalcium fluxMonoclonal antibodiesMicroparticle generationCytometryGranule contentsCytometric methodologyPlateletsGlycoprotein receptorsSecretionAntibodiesReceptors
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