2024
SF3B1 Mutations Lead to Changes in Fine-Scale Chromatin Organization through Impaired Transcription
Roy R, Gupta A, Pillai M, Boddu P. SF3B1 Mutations Lead to Changes in Fine-Scale Chromatin Organization through Impaired Transcription. Blood 2024, 144: 1813. DOI: 10.1182/blood-2024-211548.Peer-Reviewed Original ResearchPol II densityPol IIGenome binsGenome organizationMutant cellsSplicing factorsEnhancer-promoterEP pairsH3K27ac ChIP-seq dataHi-C protocolPol II distributionChIP-seq dataChIP-seq datasetsEnhancer-promoter interactionsPol II transcriptionRNA polymerase IIPromoter chromatin architecturePol II pausingSF3B1-mutant cellsPaused Pol IIChromatin organization changesFine-scalePutative enhancer regionsGene promoter regionChIP-seq
2014
Compromised RNA polymerase III complex assembly leads to local alterations of intergenic RNA polymerase II transcription in Saccharomyces cerevisiae
Wang Q, Nowak C, Korde A, Oh D, Dassanayake M, Donze D. Compromised RNA polymerase III complex assembly leads to local alterations of intergenic RNA polymerase II transcription in Saccharomyces cerevisiae. BMC Biology 2014, 12: 89. PMID: 25348158, PMCID: PMC4228148, DOI: 10.1186/s12915-014-0089-x.Peer-Reviewed Original ResearchMeSH KeywordsBinding SitesChromatinChromosome MappingDNA, IntergenicGene Expression Regulation, FungalGenetic LociGenome, FungalGenotypeOpen Reading FramesPromoter Regions, GeneticRNA Polymerase IIRNA Polymerase IIISaccharomyces cerevisiaeSequence Analysis, RNATranscription Factors, TFIIITranscription Initiation SiteTranscriptomeConceptsPol III complexesPol II transcriptionAdjacent genesIntergenic regionComplex assemblyRNA polymerase III complexRNA polymerase II transcriptionMicroarray studiesTranscription factor TFIIICSynthetic biology effortsPolymerase II transcriptionRNA polymerase IITranscriptional start sitePol II promotersChromatin processesYeast genomePolymerase IIFactor mutantsStart sitePol IIIRNA sequencingETC sitesTranslational levelUpstream transcriptsWild type
2012
Hypoxia sensing by Fe2+/α‐KG dependent dioxygenases regulate hmU synthesis in trypanosome DNA, chromatin structure and Pol II transcription
sabatini R, cliffe L, ekanayake D, Hirsch G. Hypoxia sensing by Fe2+/α‐KG dependent dioxygenases regulate hmU synthesis in trypanosome DNA, chromatin structure and Pol II transcription. The FASEB Journal 2012, 26: 535.16-535.16. DOI: 10.1096/fasebj.26.1_supplement.535.16.Peer-Reviewed Original ResearchThymidine hydroxylaseBase JIncreased parasite virulenceIncreased Pol II occupancyPol II transcription initiationGene expressionRegulation of gene expressionPol II occupancyPol II transcriptionGenome-wide changesSynthetic DNA substratesParasite virulenceGrowth of T. cruziOxygen-dependent mannerIncreased histone acetylationTranscription initiationDioxygenase superfamilyII transcriptionChromatin structureDNA substratesTranscriptional regulationIn vivo analysisPromoter regionHistone acetylationHost environment
2011
Epigenetic Regulation of Transcription and Virulence in Trypanosoma cruzi by O-Linked Thymine Glucosylation of DNA
Ekanayake D, Minning T, Weatherly B, Gunasekera K, Nilsson D, Tarleton R, Ochsenreiter T, Sabatini R. Epigenetic Regulation of Transcription and Virulence in Trypanosoma cruzi by O-Linked Thymine Glucosylation of DNA. Molecular And Cellular Biology 2011, 31: 1690-1700. PMID: 21321080, PMCID: PMC3126337, DOI: 10.1128/mcb.01277-10.Peer-Reviewed Original ResearchConceptsPolycistronic unitsBase JTranscription initiationPol II transcription initiationSite of transcription initiationGene expressionEpigenetic regulation of transcriptionPolycistronic gene clustersProtein-coding genesPol II transcriptionGenome-wide increaseRegulation of transcriptionHost cell invasionRegulate gene expressionDNA basePolymerase IIVirulence genesGene clusterPol IIII transcriptionAffected genesPosttranscriptional processesEpigenetic regulationBiological roleEpigenetic factors
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