2024
SF3B1 Mutations Lead to Changes in Fine-Scale Chromatin Organization through Impaired Transcription
Roy R, Gupta A, Pillai M, Boddu P. SF3B1 Mutations Lead to Changes in Fine-Scale Chromatin Organization through Impaired Transcription. Blood 2024, 144: 1813. DOI: 10.1182/blood-2024-211548.Peer-Reviewed Original ResearchPol II densityPol IIGenome binsGenome organizationMutant cellsSplicing factorsEnhancer-promoterEP pairsH3K27ac ChIP-seq dataHi-C protocolPol II distributionChIP-seq dataChIP-seq datasetsEnhancer-promoter interactionsPol II transcriptionRNA polymerase IIPromoter chromatin architecturePol II pausingSF3B1-mutant cellsPaused Pol IIChromatin organization changesFine-scalePutative enhancer regionsGene promoter regionChIP-seqLiver epigenomic signature associated with chronic oxidative stress in a mouse model of glutathione deficiency
Hong S, Yu X, Zhu Y, Chen Y. Liver epigenomic signature associated with chronic oxidative stress in a mouse model of glutathione deficiency. Chemico-Biological Interactions 2024, 398: 111093. PMID: 38830566, PMCID: PMC11223951, DOI: 10.1016/j.cbi.2024.111093.Peer-Reviewed Original ResearchS-adenosyl methionineGene promoterArray-based DNA methylation profilingPeripheral blood cellsFatty liver diseaseDNA methylation profilesDNA methylation statusMethyl donor S-adenosyl methionineGene promoter regionFunctional enrichment analysisMethylation enrichmentMouse modelOxidative stressLiver epigenomeEpigenomic changesIn vivo interplayMethylation profilesPromoter regionEpigenetic regulationEpigenomic signaturesEpigenetic mechanismsLipid homeostasisBlood cellsEnrichment analysisCellular survival
2018
Effects of histone methyltransferase inhibition in endometriosis†
Colón-Caraballo M, Torres-Reverón A, Soto-Vargas J, Young S, Lessey B, Mendoza A, Urrutia R, Flores I. Effects of histone methyltransferase inhibition in endometriosis†. Biology Of Reproduction 2018, 99: 293-307. PMID: 29408993, PMCID: PMC6373837, DOI: 10.1093/biolre/ioy030.Peer-Reviewed Original ResearchConceptsEndometriotic lesionsGene promoter regionEndometriotic cellsEndometriotic epithelial cellsPromoter regionInhibition of EZH2In vivo efficacyHistone methyltransferase EZH2Nonhormonal treatmentsImmunostaining levelsTissue microarrayEndometriotic tissueEutopic endometriumPreclinical studiesLevels of EZH2Invasion in vitroInvasion of endometriotic cellsGynecological diseasesEZH2 inhibitorsEZH2 protein levelsMethyltransferase inhibitionChromatin immunoprecipitation-qPCREpithelial cellsPharmacological inhibitionPharmacological inhibitors
2014
Identification of methylation quantitative trait loci (mQTLs) influencing promoter DNA methylation of alcohol dependence risk genes
Zhang H, Wang F, Kranzler HR, Yang C, Xu H, Wang Z, Zhao H, Gelernter J. Identification of methylation quantitative trait loci (mQTLs) influencing promoter DNA methylation of alcohol dependence risk genes. Human Genetics 2014, 133: 1093-1104. PMID: 24889829, PMCID: PMC4127343, DOI: 10.1007/s00439-014-1452-2.Peer-Reviewed Original ResearchConceptsMethylation quantitative trait lociQuantitative trait lociDNA methylationTrait lociSignificant methylation quantitative trait lociSequence variantsRisk genesGene expression regulationGenome-wide association studiesGenome-wide genotype dataPromoter DNA methylationAD risk genesGene promoter regionExpression QTLsExpression regulationGenetic variationPromoter CpGsPromoter region
2010
Targeting Sp1 Transactivation In Waldenstrom's Macroglobulinemia: a Novel Therapeutic Option
Fulciniti M, Amin S, Mohan V, Yang G, Nanjappa P, Tassone P, Prabhala R, Cheng L, Anderson K, Treon S, Munshi N. Targeting Sp1 Transactivation In Waldenstrom's Macroglobulinemia: a Novel Therapeutic Option. Blood 2010, 116: 120. DOI: 10.1182/blood.v116.21.120.120.Peer-Reviewed Original ResearchBone marrow stromal cellsSp1 activityWM cellsCell growthSp1 protein expressionSp1 protein levelsTranscription factor Sp1Lentiviral shRNA constructsGC-rich motifsCaspase-8 activationImportant transcription factorMitochondrial apoptotic pathwayExpression of genesAnti-apoptotic genesGene promoter regionHigh Sp1 expressionSp1 transactivationLuciferase reporter plasmidFactor Sp1Sp proteinsSp1 inhibitorDownregulation of expressionSp1 expressionTranscription factorsPromoter elements
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