Hypoxia sensing by Fe2+/α‐KG dependent dioxygenases regulate hmU synthesis in trypanosome DNA, chromatin structure and Pol II transcription
sabatini R, cliffe L, ekanayake D, Hirsch G. Hypoxia sensing by Fe2+/α‐KG dependent dioxygenases regulate hmU synthesis in trypanosome DNA, chromatin structure and Pol II transcription. The FASEB Journal 2012, 26: 535.16-535.16. DOI: 10.1096/fasebj.26.1_supplement.535.16.Peer-Reviewed Original ResearchThymidine hydroxylaseBase JIncreased parasite virulenceIncreased Pol II occupancyPol II transcription initiationGene expressionRegulation of gene expressionPol II occupancyPol II transcriptionGenome-wide changesSynthetic DNA substratesParasite virulenceGrowth of T. cruziOxygen-dependent mannerIncreased histone acetylationTranscription initiationDioxygenase superfamilyII transcriptionChromatin structureDNA substratesTranscriptional regulationIn vivo analysisPromoter regionHistone acetylationHost environment
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