Epigenetic Regulation of Transcription and Virulence in Trypanosoma cruzi by O-Linked Thymine Glucosylation of DNA
Ekanayake D, Minning T, Weatherly B, Gunasekera K, Nilsson D, Tarleton R, Ochsenreiter T, Sabatini R. Epigenetic Regulation of Transcription and Virulence in Trypanosoma cruzi by O-Linked Thymine Glucosylation of DNA. Molecular And Cellular Biology 2011, 31: 1690-1700. PMID: 21321080, PMCID: PMC3126337, DOI: 10.1128/mcb.01277-10.Peer-Reviewed Original ResearchConceptsPolycistronic unitsBase JTranscription initiationPol II transcription initiationSite of transcription initiationGene expressionEpigenetic regulation of transcriptionPolycistronic gene clustersProtein-coding genesPol II transcriptionGenome-wide increaseRegulation of transcriptionHost cell invasionRegulate gene expressionDNA basePolymerase IIVirulence genesGene clusterPol IIII transcriptionAffected genesPosttranscriptional processesEpigenetic regulationBiological roleEpigenetic factors
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