2024
WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury
Wang Y, Cui C, Zhao W, Tian X, Liu P, Wei L, Zhu Z, Liu M, Fu R, Jia L. WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury. Immunobiology 2024, 229: 152832. PMID: 38943814, DOI: 10.1016/j.imbio.2024.152832.Peer-Reviewed Original ResearchAcute kidney injuryAcute tubular injuryLPS-induced acute kidney injuryHuman kidney 2Wip1 activityKidney injuryRenal tubulesUnilateral ischemia-reperfusion injurySepsis-associated acute kidney injuryRenal tubules of patientsHK2 cellsProtein levelsInduce acute injuryProximal renal tubulesWild-type p53-induced phosphatase 1Ischemia-reperfusion injuryPhosphorylation of p38 MAPKGSDMD-NHuman kidney-2 cellsSingle-cell sequencingPPM1D mRNAPhospho-p38 MAPKTubular injuryWip1 inhibitorScRNA-seq
2018
Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy
Curry Z, Wilkerson J, Bagdas D, Kyte S, Patel N, Donvito G, Mustafa M, Poklis J, Niphakis M, Hsu K, Cravatt B, Gewirtz D, Damaj M, Lichtman A. Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy. Journal Of Pharmacology And Experimental Therapeutics 2018, 366: 169-183. PMID: 29540562, PMCID: PMC6038031, DOI: 10.1124/jpet.117.245704.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsApoptosisBenzodioxolesBiomarkersCarbamatesCell Line, TumorCell ProliferationChemokine CCL2Disease Models, AnimalDose-Response Relationship, DrugEnzyme InhibitorsHumansHyperalgesiaInflammationMaleMiceMonoacylglycerol LipasesNociceptionp38 Mitogen-Activated Protein KinasesPaclitaxelPhosphoproteinsPiperidinesReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2SuccinimidesConceptsAntinociceptive effectPaclitaxel-induced mechanical allodyniaPaclitaxel-induced neuropathic painH460 non-small cell lung cancer cellsNon-small cell lung cancer cellsMonoacylglycerol lipaseMonocyte chemoattractant protein-1Chemotherapy-induced neuropathyPaclitaxel-induced allodyniaPain side effectsPrimary hydrolytic enzymesCell lung cancer cellsSpinal dorsal hornDorsal root gangliaChemoattractant protein-1Novel pharmacologic strategiesPaclitaxel-treated animalsNumerous rodent modelsLung cancer cellsPlace preference paradigmMonoacylglycerol lipase inhibitorsIntrinsic rewarding effectsPhospho-p38 MAPKMechanical allodyniaNeuropathic pain
2003
Role of PP2A in the regulation of p38 MAPK activation in bovine aortic endothelial cells exposed to cyclic strain
Lee T, Kim SJ, Sumpio BE. Role of PP2A in the regulation of p38 MAPK activation in bovine aortic endothelial cells exposed to cyclic strain. Journal Of Cellular Physiology 2003, 194: 349-355. PMID: 12548554, DOI: 10.1002/jcp.10211.Peer-Reviewed Original ResearchConceptsP38 MAPK activationMAPK activationCatalytic subunitBovine aortic endothelial cellsPhospho-p38 MAPKOkadaic acidProtein phosphatase type 2AInhibitor of PP2AAortic endothelial cellsEndothelial cellsProtein kinaseRapid phosphorylationPP2AP38 mitogenRegulatory roleCell lysatesPhosphatase activityPP2AcMAPKPhosphorylationCyclic strainSubunitsType 2ACyclic strain resultsCells
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