2025
Nonpharmacologic Interventions to Improve Postural Control Among Breast Cancer Survivors With Chemotherapy-induced Neuropathy
Luciani B, Schnell P, Bland C, Wilder J, Lantis K, Hock K, Hackney M, Lustberg M, Worthen-Chaudhari L. Nonpharmacologic Interventions to Improve Postural Control Among Breast Cancer Survivors With Chemotherapy-induced Neuropathy. Archives Of Physical Medicine And Rehabilitation 2025, 106: e130-e131. DOI: 10.1016/j.apmr.2025.01.338.Peer-Reviewed Original ResearchPostural control improvementHome exercisesActivity-based interventionsPostural controlBC survivorsNonpharmacological interventionsHome exercise groupImprove postural controlPostural control deficitsBreast cancer survivorsMeasure postural controlMonths follow-upChemotherapy-induced neuropathyWeeks of interventionBreast cancerMain outcome measuresBilateral standingCancer survivorsFall riskCourse of interventionIntervention effectsTango danceLinear mixed modelsBiomechanical measuresOutcome measures
2024
Neurologic dance training and home exercise improve motor-cognitive dual-task function similarly, but through potentially different mechanisms, among breast cancer survivors with chemotherapy-induced neuropathy: Initial results of a randomized, controlled clinical trial
Worthen-Chaudhari L, Crasta J, Schnell P, Lantis K, Martis J, Wilder J, Bland C, Hackney M, Lustberg M. Neurologic dance training and home exercise improve motor-cognitive dual-task function similarly, but through potentially different mechanisms, among breast cancer survivors with chemotherapy-induced neuropathy: Initial results of a randomized, controlled clinical trial. Journal Of Alzheimer’s Disease 2024, 105: 1114-1130. PMID: 39584292, DOI: 10.1177/13872877241291440.Peer-Reviewed Original ResearchDual-task functionSurvivors of BCHome exercisesParticipants' ratings of perceived exertionSurvivors of breast cancerRating of perceived exertionTimed-Up-and-GoBreast cancer survivorsChemotherapy-induced neuropathyWeeks of interventionBreast cancerConventional exerciseDual-task performanceCancer survivorsIntervention adherencePhysical activityDance interventionAlzheimer's diseaseProdromal Alzheimer's diseaseSocial dancePhysical exertionParticipation ratesExerciseMonths follow-upFeasibility criteriaMeasuring Progress in Breast Cancer Survivors With Chemotherapy-Induced Neuropathy After a Dance-Based Intervention Using Goal Attainment Scaling
Watson-Grace A, Bland C, Wilder J, Lantis K, Hackney M, Lustberg M, Worthen-Chaudhari L, Crasta J. Measuring Progress in Breast Cancer Survivors With Chemotherapy-Induced Neuropathy After a Dance-Based Intervention Using Goal Attainment Scaling. American Journal Of Occupational Therapy 2024, 78: 7811500037p1-7811500037p1. DOI: 10.5014/ajot.2024.78s2-po37.Peer-Reviewed Original Research
2023
Biomechanical effect of neurologic dance training (NDT) for breast cancer survivors with chemotherapy-induced neuropathy: study protocol for a randomized controlled trial and preliminary baseline data
Lantis K, Schnell P, Bland C, Wilder J, Hock K, Vargo C, Glover N, Hackney M, Lustberg M, Worthen-Chaudhari L. Biomechanical effect of neurologic dance training (NDT) for breast cancer survivors with chemotherapy-induced neuropathy: study protocol for a randomized controlled trial and preliminary baseline data. Trials 2023, 24: 564. PMID: 37658464, PMCID: PMC10472642, DOI: 10.1186/s13063-023-07554-z.Peer-Reviewed Original ResearchConceptsChemotherapy-induced neuropathyPhysical activityBackgroundBreast cancerOutcome measuresNon-pharmacologic interventionsBreast cancer survivorsPrimary outcome measureHome exercise interventionQuality of lifeControl intervention groupPreliminary baseline dataPrimary endpointExercise interventionBC survivorsTertiary outcomesCancer survivorsSensorimotor symptomsClinical trialsIntervention groupTwo-armWeek 8Mean changeFall riskPrimary estimandTreatment groupsCalcium signaling in chemotherapy-induced neuropathy
Fonseca M, Marazzi-Diniz P, Leite M, Ehrlich B. Calcium signaling in chemotherapy-induced neuropathy. Cell Calcium 2023, 113: 102762. PMID: 37244172, DOI: 10.1016/j.ceca.2023.102762.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyNeuronal calcium sensor-1Chemotherapy-induced cognitive impairmentMultiple chemotherapy regimensChemotherapy-induced neuropathyDisease-modifying treatmentsQuality of lifeChemotherapy regimensChemotherapy dosePeripheral neuropathyPathophysiological cascadePatient outcomesOptimal chemotherapySide effectsCognitive impairmentChemotherapeutic agentsTarget toxicityCancer cellsSensitive CaCalcium signalingOff-target effectsNeuropathyTaxanesTreatmentMolecular mechanismsEffect of Partnered Dance Intervention on Upper Extremity Outcomes for Breast Cancer Survivors With CIPN
Bland C, Worthen-Chaudhari L, Hackney M, Lustberg M, Crasta J. Effect of Partnered Dance Intervention on Upper Extremity Outcomes for Breast Cancer Survivors With CIPN. Archives Of Physical Medicine And Rehabilitation 2023, 104: e24. DOI: 10.1016/j.apmr.2022.12.067.Peer-Reviewed Original ResearchBreast cancer survivorsHand grip strengthGrip strengthCancer survivorsUpper extremity outcomesChemotherapy-induced neuropathyUpper extremity functionSenior Fitness TestCase seriesExtremity functionOutpatient oncologyBreast cancerJamar dynamometerMAIN OUTCOMEDance interventionDance-based interventionBalance deficitsFitness testsT-testCIPNTango danceInterventionSurvivorsOutcomesNeuropathySensorimotor Cortical Thickness Changes Following Taxane-Based Chemotherapy: Support for a CNS Role in CIPN?
Worthen-Chaudhari L, Monfort S, Chaudhari A, Lustberg M. Sensorimotor Cortical Thickness Changes Following Taxane-Based Chemotherapy: Support for a CNS Role in CIPN? Archives Of Physical Medicine And Rehabilitation 2023, 104: e51. DOI: 10.1016/j.apmr.2022.12.148.Peer-Reviewed Original ResearchChemotherapy cyclesCortical thicknessBrain changesBreast cancerSensorimotor regionsCycles of TaxolSensorimotor cortical thicknessChemotherapy-induced neuropathyFirst chemotherapy cycleBreast cancer survivorsMain outcome measuresMean cortical thicknessSensory-motor regionsBrain structural integrityTaxane exposureChemotherapy exposureCancer survivorsCentral effectsChemotherapy treatmentDesign ProspectiveOutpatient oncologyCNS roleCommencement of studyOutcome measuresGait variabilityGoal Attainment Scaling with a Dance-Based Intervention for Breast Cancer Survivors With CIPN: Pilot Study
Bland C, Worthen-Chaudhari L, Hackney M, Crasta J, Lustberg M. Goal Attainment Scaling with a Dance-Based Intervention for Breast Cancer Survivors With CIPN: Pilot Study. Archives Of Physical Medicine And Rehabilitation 2023, 104: e31-e32. DOI: 10.1016/j.apmr.2022.12.089.Peer-Reviewed Original ResearchChemotherapy-induced neuropathyBreast cancer survivorsGoal Attainment ScalingCancer survivorsIndividualized goalsClinical utilityT-scoreDance-based interventionPilot intervention studyLevel of functioningGAS T-scoresOverall T scoreOutpatient oncologyBreast cancerMAIN OUTCOMEPost interventionNeuropathyIntervention studiesLarger sample sizePaired-samples t-testPilot studyChange scoresSurvivorsInterventionFurther studiesCase Study in Chemotherapy-Induced Neuropathy: Tango Dance Improved Over-Ground Local Gait Stability
Glover N, WIlder J, Patrick S, Hackney M, Lustberg M, Worthen-Chaudhari L. Case Study in Chemotherapy-Induced Neuropathy: Tango Dance Improved Over-Ground Local Gait Stability. Archives Of Physical Medicine And Rehabilitation 2023, 104: e16. DOI: 10.1016/j.apmr.2022.12.044.Peer-Reviewed Original ResearchChemotherapy-induced neuropathyGait stability indexBreast cancerGait stabilityTango danceDynamic gait stabilityOncology outpatientsBC survivorsSteady-state gaitGait assessmentClinical utilityNeuromechanical functionNeuropathyBalance deficitsInterventionFurther studiesHuman applicationSurvivorsMovement variabilityWeeksTest assessmentAssessmentOutpatientsCancerPerson's resistance
2020
Activation of sphingosine 1-phosphate receptor 2 attenuates chemotherapy-induced neuropathy
Wang W, Xiang P, Chew W, Torta F, Bandla A, Lopez V, Seow W, Lam B, Chang J, Wong P, Chayaburakul K, Ong W, Wenk M, Sundar R, Herr D. Activation of sphingosine 1-phosphate receptor 2 attenuates chemotherapy-induced neuropathy. Journal Of Biological Chemistry 2020, 295: 1143-1152. DOI: 10.1016/s0021-9258(17)49922-4.Peer-Reviewed Original ResearchChemotherapy-induced neuropathyRat model of cisplatin-induced neuropathyManagement of chemotherapy-induced neuropathyTreatment of chemotherapy-induced neuropathyS1P speciesEffects of platinum-based drugsCisplatin-induced neuropathyPlasma S1P levelsDorsal root gangliaHuman cancer patientsActivating stress-response proteinsPlatinum-based drugsSphingosine 1-phosphateReduced allodyniaS1P1 signalingOxaliplatin treatmentPharmacodynamic analysisPeripheral neuropathyRat modelCancer patientsLipid-based signaling moleculesS1P concentrationsS1P levelsCYM-5478Platinum-based therapeutics
2019
Activation of sphingosine 1-phosphate receptor 2 attenuates chemotherapy-induced neuropathy
Wang W, Xiang P, Chew W, Torta F, Bandla A, Lopez V, Seow W, Lam B, Chang J, Wong P, Chayaburakul K, Ong W, Wenk M, Sundar R, Herr D. Activation of sphingosine 1-phosphate receptor 2 attenuates chemotherapy-induced neuropathy. Journal Of Biological Chemistry 2019, 295: 1143-1152. PMID: 31882542, PMCID: PMC6983853, DOI: 10.1074/jbc.ra119.011699.Peer-Reviewed Original ResearchConceptsChemotherapy-induced neuropathyRat model of cisplatin-induced neuropathyManagement of chemotherapy-induced neuropathyTreatment of chemotherapy-induced neuropathyS1P speciesEffects of platinum-based drugsCisplatin-induced neuropathyPlasma S1P levelsDorsal root gangliaS1P<sub>1-5</sub>Human cancer patientsActivating stress-response proteinsPlatinum-based drugsReduced allodyniaSphingosine 1-phosphateOxaliplatin treatmentPharmacodynamic analysisPeripheral neuropathyRat modelS1PCancer patientsLipid-based signaling moleculesS1P concentrationsS1P levelsCYM-5478
2018
Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy
Curry Z, Wilkerson J, Bagdas D, Kyte S, Patel N, Donvito G, Mustafa M, Poklis J, Niphakis M, Hsu K, Cravatt B, Gewirtz D, Damaj M, Lichtman A. Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy. Journal Of Pharmacology And Experimental Therapeutics 2018, 366: 169-183. PMID: 29540562, PMCID: PMC6038031, DOI: 10.1124/jpet.117.245704.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsApoptosisBenzodioxolesBiomarkersCarbamatesCell Line, TumorCell ProliferationChemokine CCL2Disease Models, AnimalDose-Response Relationship, DrugEnzyme InhibitorsHumansHyperalgesiaInflammationMaleMiceMonoacylglycerol LipasesNociceptionp38 Mitogen-Activated Protein KinasesPaclitaxelPhosphoproteinsPiperidinesReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2SuccinimidesConceptsAntinociceptive effectPaclitaxel-induced mechanical allodyniaPaclitaxel-induced neuropathic painH460 non-small cell lung cancer cellsNon-small cell lung cancer cellsMonoacylglycerol lipaseMonocyte chemoattractant protein-1Chemotherapy-induced neuropathyPaclitaxel-induced allodyniaPain side effectsPrimary hydrolytic enzymesCell lung cancer cellsSpinal dorsal hornDorsal root gangliaChemoattractant protein-1Novel pharmacologic strategiesPaclitaxel-treated animalsNumerous rodent modelsLung cancer cellsPlace preference paradigmMonoacylglycerol lipase inhibitorsIntrinsic rewarding effectsPhospho-p38 MAPKMechanical allodyniaNeuropathic pain
2015
Hypothermia for preventing chemotherapy-induced neuropathy – a pilot study on safety and tolerability in healthy controls
Bandla A, Sundar R, Liao L, Tan S, Lee S, Thakor N, Wilder-Smith E. Hypothermia for preventing chemotherapy-induced neuropathy – a pilot study on safety and tolerability in healthy controls. Acta Oncologica 2015, 55: 430-436. PMID: 26360921, DOI: 10.3109/0284186x.2015.1075664.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyHealthy human subjectsHealthy subjectsSevere chemotherapy-induced peripheral neuropathyDose-limiting side effectReduced nerve blood flowSeverity of chemotherapy-induced peripheral neuropathyLimb hypothermiaAdjuvant weekly paclitaxelChemotherapy-induced neuropathyNerve blood flowDuration of chemotherapyBreast cancer patientsSuccess of chemotherapyInfluence of hypothermiaEffects of hypothermiaWeekly paclitaxelSignificant adverse effectsPaclitaxel chemotherapyTreatment discontinuationTransient numbnessDose-relatedNeurotoxic drugsHuman subjectsCancer subjects
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply