2023
The promise of metabolic imaging in diffuse midline glioma
Lovibond S, Gewirtz A, Pasquini L, Krebs S, Graham M. The promise of metabolic imaging in diffuse midline glioma. Neoplasia 2023, 39: 100896. PMID: 36944297, PMCID: PMC10036941, DOI: 10.1016/j.neo.2023.100896.Peer-Reviewed Original ResearchConceptsDiffuse midline gliomaMagnetic resonance imagingPositron emission tomographyMidline gliomaNeuro-oncologyMolecular subgroups of gliomasPediatric diffuse midline gliomasBrain tumorsH3 K27-alteredField of neuro-oncologyStandard magnetic resonance imagingPediatric neuro-oncologyConventional magnetic resonance imagingSubgroup of gliomasAdvanced magnetic resonance imagingTreatment response monitoringFeatures of brain tumorsNon-invasive evaluationRare tumorDismal prognosisClinical presentationTumor biologyMolecular subgroupsTumorImaging surrogate
2021
Topographic correlates of driver mutations and endogenous gene expression in pediatric diffuse midline gliomas and hemispheric high-grade gliomas
Kazarian E, Marks A, Cui J, Darbinyan A, Tong E, Mueller S, Cha S, Aboian MS. Topographic correlates of driver mutations and endogenous gene expression in pediatric diffuse midline gliomas and hemispheric high-grade gliomas. Scientific Reports 2021, 11: 14377. PMID: 34257334, PMCID: PMC8277861, DOI: 10.1038/s41598-021-92943-0.Peer-Reviewed Original ResearchConceptsHigh-grade gliomasDiffuse midline gliomaPediatric diffuse midline gliomasMidline gliomaGene panel testingDriver mutationsPanel testingTumor board reviewK27M mutationPediatric patientsNormal gene expression patternsH3 K27M-mutationImaging featuresPreoperative MRIEndogenous gene expressionCerebral hemispheresGliomas correlatesNormal brainGene expression patternsMutation testingPatientsTopographic distributionGliomasM mutationIDH1 mutation
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