Intrinsic Pathway of Hydroquinone Induced Apoptosis Occurs via Both Caspase-Dependent and Caspase-Independent Mechanisms
Inayat-Hussain S, Ross D. Intrinsic Pathway of Hydroquinone Induced Apoptosis Occurs via Both Caspase-Dependent and Caspase-Independent Mechanisms. Chemical Research In Toxicology 2005, 18: 420-427. PMID: 15777082, DOI: 10.1021/tx049762o.Peer-Reviewed Original ResearchConceptsMitochondrial transmembrane potentialLoss of MTPApical caspases-8Caspase-independent mechanismHL-60 cellsJurkat cellsCaspase-8Pan-caspase inhibitor benzyloxycarbonylBenzene metabolite hydroquinonePresence of zVADInvolvement of mitochondriaAsp-fluoromethyl ketoneCaspase-dependent processCytochrome c.Executioner caspase-3Role of mitochondriaCaspase-8 processingPhosphatidyl serine exposureIntrinsic apoptotic pathwayPS exposureJurkat T cellsHL-60Apical caspasesCaspase-9 processingCaspase-Dependent
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