2023
Ketogenic diet enhances the effects of oxycodone in mice
Trinko R, Diaz D, Foscue E, Thompson S, Taylor J, DiLeone R. Ketogenic diet enhances the effects of oxycodone in mice. Scientific Reports 2023, 13: 7507. PMID: 37160959, PMCID: PMC10170077, DOI: 10.1038/s41598-023-33458-8.Peer-Reviewed Original ResearchConceptsOpioid use disorderKetogenic dietKD miceUse disordersTreatment of OUDEffects of KDEffects of oxycodoneClinical pain managementAlcohol use disorderProgressive ratio scheduleSex-specific effectsChronic oxycodoneLess oxycodoneOpioid withdrawalAntinociceptive effectPain managementPrescription opioidsSide effectsOxycodoneLocomotor activityTherapeutic potentialOpioidsDietary effectsOpiate sensitivityMice
2022
A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use
Choucair I, Villalba C, Vera M, Cassella-Mclane G, Durant T, El-Khoury J. A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use. Clinical Biochemistry 2022, 112: 6-10. PMID: 36535386, DOI: 10.1016/j.clinbiochem.2022.12.009.Peer-Reviewed Original ResearchConceptsConcentrations of hydrocodoneMean ratioOxycodone pillsPrescription complianceOpioid useUDT resultsMedication recordsOxycodoneAdditional opiatesPatientsHydromorphoneLarger sample sizeAbstractTextHydrocodoneDrug abuseLiquid chromatography-tandem mass spectrometryDrug testingChromatography-tandem mass spectrometryLC-MS/MSFurther validationPreliminary studySample sizeOpiatesSensitive methodPillsCompliance or Abuse? Detectable hydromorphone in patients taking oxycodone
Villalba C, Choucair I, El-Khoury J. Compliance or Abuse? Detectable hydromorphone in patients taking oxycodone. American Journal Of Clinical Pathology 2022, 158: s5-s6. DOI: 10.1093/ajcp/aqac126.008.Peer-Reviewed Original ResearchBilateral upper extremity paresthesiasMetabolites of oxycodoneUpper extremity paresthesiasUrine drug monitoringUrine samplesMiddle-aged womenQuality improvement projectPositive urine samplesAspen collarOpioid therapyOxycodone preparationsMechanical fallOpioid medicationsExtremity paresthesiasCervical diskectomyChronic painSurgical interventionUrine testsOrthopaedic servicesSpinal fusionOxycodonePatientsHydromorphoneDrug monitoringHydrocodone
2021
Minocycline attenuates oxycodone-induced positive subjective responses in non-dependent, recreational opioid users
Mogali S, Askalsky P, Madera G, Jones JD, Comer SD. Minocycline attenuates oxycodone-induced positive subjective responses in non-dependent, recreational opioid users. Pharmacology Biochemistry And Behavior 2021, 209: 173241. PMID: 34298029, PMCID: PMC8429209, DOI: 10.1016/j.pbb.2021.173241.Peer-Reviewed Original ResearchConceptsAnalgesic effectRecreational opioid usersReceptor-selective agonistOpioid usersPreclinical studiesAbuse liabilityNew York State Psychiatric InstituteRelease of cytokinesPositive subjective effectsTetracycline antibiotic minocyclineYears of ageDouble-blind outpatient studyPositive subjective responsesGlial activationAcute administrationCertain medicationsHuman research volunteersOutpatient studyGlial cellsNon-treatment seekingSame dosesRewarding effectsOxycodoneDrug AdministrationMinocycline
2017
Effects of Ibudilast on the Subjective, Reinforcing, and Analgesic Effects of Oxycodone in Recently Detoxified Adults with Opioid Dependence
Metz VE, Jones JD, Manubay J, Sullivan MA, Mogali S, Segoshi A, Madera G, Johnson KW, Comer SD. Effects of Ibudilast on the Subjective, Reinforcing, and Analgesic Effects of Oxycodone in Recently Detoxified Adults with Opioid Dependence. Neuropsychopharmacology 2017, 42: 1825-1832. PMID: 28393896, PMCID: PMC5520790, DOI: 10.1038/npp.2017.70.Peer-Reviewed Original ResearchConceptsEffect of ibudilastVisual analog scaleAnalgesic effectOpioid dependenceEffects of oxycodoneGlial cell activationOpioid use disorderTreatment of asthmaDrug Effects QuestionnaireRecent preclinical studiesCold pressor testNonselective phosphodiesterase inhibitorMaintenance doseOxycodone administrationAnalog scaleWithdrawal symptomsDrug likingHeroin cravingPressor testMale volunteersPreclinical studiesIbudilastPatient detoxificationUse disordersOxycodone
2016
Cost‐Effectiveness of Tramadol and Oxycodone in the Treatment of Knee Osteoarthritis
Smith SR, Katz JN, Collins JE, Solomon DH, Jordan JM, Suter LG, Yelin EH, Paltiel AD, Losina E. Cost‐Effectiveness of Tramadol and Oxycodone in the Treatment of Knee Osteoarthritis. Arthritis Care & Research 2016, 69: 234-242. PMID: 27111538, PMCID: PMC5378156, DOI: 10.1002/acr.22916.Peer-Reviewed Original ResearchConceptsIncremental cost-effectiveness ratioQuality-adjusted life yearsOA patientsTKA outcomesKnee OA patientsKnee osteoarthritis treatmentInfluence of opioidsOsteoarthritis Policy ModelCost-effectiveness ratioConservative treatmentPain reductionPain reliefPersistent painKnee osteoarthritisMean ageTKA utilizationTreatment optionsOsteoarthritis treatmentLife yearsOxycodoneTramadolTKALifetime costsOpioidsOutcomesOxycodone physical dependence and its oral self-administration in C57BL/6J mice
Enga RM, Jackson A, Damaj MI, Beardsley PM. Oxycodone physical dependence and its oral self-administration in C57BL/6J mice. European Journal Of Pharmacology 2016, 789: 75-80. PMID: 27393461, PMCID: PMC5824624, DOI: 10.1016/j.ejphar.2016.07.006.Peer-Reviewed Original ResearchConceptsConcentrations of oxycodonePost-prandial conditionsPhysical dependenceAntinociceptive effectPreclinical reportsPrescription opioidsAbused prescription opioidDoses of oxycodoneAbuse-related effectsOperant self-administration procedureSelf-administer waterSelf-administration procedureNumber of deliveriesOxycodone withdrawalNovel regimenOral oxycodoneNaloxone doseSomatic signsOxycodoneLimited access conditionsRegimenClinical useMiceOpioidsPositive reinforcer
2015
The effects of pioglitazone, a PPARγ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users
Jones JD, Sullivan MA, Manubay JM, Mogali S, Metz VE, Ciccocioppo R, Comer SD. The effects of pioglitazone, a PPARγ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users. Physiology & Behavior 2015, 159: 33-39. PMID: 26455893, PMCID: PMC5444321, DOI: 10.1016/j.physbeh.2015.10.006.Peer-Reviewed Original ResearchConceptsEffect of pioglitazoneAbuse liabilityOpioid usersOpioid agonist effectsGood drug effectEffects of opioidsAbility of pioglitazoneActivation of PPARγPrescription opioid abusersDose-dependent increaseAddictive-like responsePositive subjective responsesMaintenance doseDaily dosesOpioid abusersOpioid receptorsPain perceptionReceptor agonistAgonist effectsDrug effectsOxycodonePioglitazoneRespiratory rateOpioidsCognitive effects
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